benzyl 5-chloro-4,4,5,5-tetrafluoro-2-iodopentyl(3-fluoro-4-morpholinophenyl)carbamate

Base Information

Chemical Name:benzyl 5-chloro-4,4,5,5-tetrafluoro-2-iodopentyl(3-fluoro-4-morpholinophenyl)carbamate
CAS No.:1428098-51-4
Molecular Formula:C₂₃H₂₃ClF₅IN₂O₃
Molecular Weight:632.797
Hs Code.:

Synonyms:benzyl 5-chloro-4,4,5,5-tetrafluoro-2-iodopentyl(3-fluoro-4-morpholinophenyl)carbamate

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Chemical Property of benzyl 5-chloro-4,4,5,5-tetrafluoro-2-iodopentyl(3-fluoro-4-morpholinophenyl)carbamate

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Technology Process of benzyl 5-chloro-4,4,5,5-tetrafluoro-2-iodopentyl(3-fluoro-4-morpholinophenyl)carbamate

There total 4 articles about benzyl 5-chloro-4,4,5,5-tetrafluoro-2-iodopentyl(3-fluoro-4-morpholinophenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.6%

: 421-78-3
1-chloro-1,1,2,2-tetrafluoro-2-iodo-ethane

: 1428098-38-7
N-allyl-N-(benzyloxycarbonyl)-3-fluoro-4-(4-morpholinyl)aniline

: 1428098-51-4
benzyl 5-chloro-4,4,5,5-tetrafluoro-2-iodopentyl(3-fluoro-4-morpholinophenyl)carbamate

Guidance literature:: With sodium dithionite; sodium hydrogencarbonate; In water; acetonitrile; at 20 ℃; for 5h;
DOI:10.1016/j.tet.2013.01.052

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1428098-51-4
benzyl 5-chloro-4,4,5,5-tetrafluoro-2-iodopentyl(3-fluoro-4-morpholinophenyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

3.1: sodium dithionite; sodium hydrogencarbonate / acetonitrile; water / 5 h / 20 °C

With sodium dithionite; sodium hydride; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; water; acetonitrile;
DOI:10.1016/j.tet.2013.01.052

Reference yield:

: 93246-53-8
3-fluoro-4-(morpholinyl)aniline

: 1428098-51-4
benzyl 5-chloro-4,4,5,5-tetrafluoro-2-iodopentyl(3-fluoro-4-morpholinophenyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

3.1: sodium dithionite; sodium hydrogencarbonate / acetonitrile; water / 5 h / 20 °C

With sodium dithionite; sodium hydride; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; water; acetonitrile;
DOI:10.1016/j.tet.2013.01.052