2,2-Dimethyl-propionic acid 3-benzyl-8-cyclopentyl-1-(2-hydroxy-ethyl)-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-ylmethyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid 3-benzyl-8-cyclopentyl-1-(2-hydroxy-ethyl)-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-ylmethyl ester
CAS No.:200557-31-9
Molecular Formula:C₂₅H₃₂N₄O₅
Molecular Weight:468.553
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid 3-benzyl-8-cyclopentyl-1-(2-hydroxy-ethyl)-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-ylmethyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid 3-benzyl-8-cyclopentyl-1-(2-hydroxy-ethyl)-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-ylmethyl ester

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Technology Process of 2,2-Dimethyl-propionic acid 3-benzyl-8-cyclopentyl-1-(2-hydroxy-ethyl)-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-ylmethyl ester

There total 7 articles about 2,2-Dimethyl-propionic acid 3-benzyl-8-cyclopentyl-1-(2-hydroxy-ethyl)-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: (3-Benzyl-8-cyclopentyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)-acetic acid tert-butyl ester

: 107-07-3
2-chloro-ethanol

: 200557-31-9
2,2-Dimethyl-propionic acid 3-benzyl-8-cyclopentyl-1-(2-hydroxy-ethyl)-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-ylmethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 24h;
DOI:10.1021/jm9705465

Reference yield:

: 4524-93-0
Cyclopentanecarboxylic acid chloride

: 200557-31-9
2,2-Dimethyl-propionic acid 3-benzyl-8-cyclopentyl-1-(2-hydroxy-ethyl)-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / CH₂Cl₂

2: 94 percent / Na₂CO₃ / dimethylformamide / Ambient temperature

3: 79 percent / K₂CO₃ / dimethylformamide / 24 h / 80 °C

With sodium carbonate; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9705465

Reference yield:

: 41862-11-7
1-benzyl-6-aminouracil

: 200557-31-9
2,2-Dimethyl-propionic acid 3-benzyl-8-cyclopentyl-1-(2-hydroxy-ethyl)-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-ylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: aq. NaNO₂, glacial AcOH / ethanol / 0.5 h / 40 °C

2: aq. sodium dithionite / 85 °C

3: 54 percent / CH₂Cl₂

4: 94 percent / Na₂CO₃ / dimethylformamide / Ambient temperature

5: 79 percent / K₂CO₃ / dimethylformamide / 24 h / 80 °C

With sodium dithionite; sodium carbonate; potassium carbonate; acetic acid; sodium nitrite; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9705465