5-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-6-(4-trifluoromethoxy-benzyloxy)-tetrahydro-furo[2,3-d][1,3]dioxole

Base Information

• Chemical Name: 5-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-6-(4-trifluoromethoxy-benzyloxy)-tetrahydro-furo[2,3-d][1,3]dioxole
• CAS No.: 916044-94-5
• Molecular Formula: C₂₀H₂₅F₃O₇
• Molecular Weight: 434.41
• Mol file: 916044-94-5.mol

Synonyms:5-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-6-(4-trifluoromethoxy-benzyloxy)-tetrahydro-furo[2,3-d][1,3]dioxole

Chemical Property of 5-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-6-(4-trifluoromethoxy-benzyloxy)-tetrahydro-furo[2,3-d][1,3]dioxole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-6-(4-trifluoromethoxy-benzyloxy)-tetrahydro-furo[2,3-d][1,3]dioxole

There total 1 articles about 5-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-6-(4-trifluoromethoxy-benzyloxy)-tetrahydro-furo[2,3-d][1,3]dioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-trifluoromethoxybenzyl bromide (50824-05-0) + 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose (582-52-5) → 5-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-6-(4-trifluoromethoxy-benzyloxy)-tetrahydro-furo[2,3-d][1,3]dioxole (916044-94-5)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1246/cl.2006.1000

Reference yield: 90.0%

5-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-6-(4-trifluoromethoxy-benzyloxy)-tetrahydro-furo[2,3-d][1,3]dioxole (916044-94-5) → 1-[2,2-dimethyl-6-(4-trifluoromethoxy-benzyloxy)-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-ethane-1,2-diol (916044-99-0)

Guidance literature:

With acetic acid; at 20 ℃; for 20h;

DOI:10.1246/cl.2006.1000

Reference yield:

5-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-6-(4-trifluoromethoxy-benzyloxy)-tetrahydro-furo[2,3-d][1,3]dioxole (916044-94-5) → 3-oxo-butyric acid 1-[2,2-dimethyl-6-(4-trifluoromethoxy-benzyloxy)-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-2-(3-oxo-butyryloxy)-ethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / aq. AcOH / 20 h / 20 °C

2: 84.5 percent / DMAP / CH₂Cl₂ / 2 h / 20 °C

With dmap; acetic acid; In dichloromethane;

DOI:10.1246/cl.2006.1000

upstream raw materials:

4-trifluoromethoxybenzyl bromide

1,2:5,6-di-O-isopropylidene-α-D-glucofuranose

Downstream raw materials:

1-[2,2-dimethyl-6-(4-trifluoromethoxy-benzyloxy)-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-ethane-1,2-diol