2-Phenyl-4-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene

Base Information

• Chemical Name: 2-Phenyl-4-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene
• CAS No.: 84703-08-2
• Molecular Formula: C₂₂H₂₀O₃
• Molecular Weight: 332.399
• Mol file: 84703-08-2.mol

Synonyms:2-Phenyl-4-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene

Chemical Property of 2-Phenyl-4-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Phenyl-4-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene

There total 2 articles about 2-Phenyl-4-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-<3-<1-phenyl-3-(p-methoxyphenyl)propan-1-onyl>>cyclohexane-1,3-dione (57857-62-2) → 2-Phenyl-4-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene (84703-08-2)

Guidance literature:

With acetic acid; at 118 - 119 ℃; for 5h; other reagent : acetic anhydride;

Reference yield: 71.0%

1,3-cylohexanedione (504-02-9) + 4'-methoxychalcone (959-23-9) → 2-Phenyl-4-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene (84703-08-2)

Guidance literature:

With tin(II) trifluoromethanesulfonate; tert-butylammonium hexafluorophosphate(V); In neat (no solvent); at 120 ℃; for 3h; Green chemistry;

DOI:10.1016/j.tetlet.2015.02.023

Reference yield: 68.0%

2-Phenyl-4-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene (84703-08-2) → 2-phenyl-4-(4-methoxyphenyl)-2-hydroxy-5-oxo-1,2,3,4,5,6,7,8-octahydroquinoline (130716-58-4)

Guidance literature:

With ammonia; In ethanol; at 50 - 60 ℃; for 20h; ampule;

DOI:10.1007/BF00497218

upstream raw materials:

2-<3-<1-phenyl-3-(p-methoxyphenyl)propan-1-onyl>>cyclohexane-1,3-dione

1,3-cylohexanedione

4'-methoxychalcone

Downstream raw materials:

2-Phenyl-3-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydroquinoline oxime

4-(4-Methoxy-phenyl)-2-phenyl-7,8-dihydro-6H-quinolin-5-one oxime; compound with hydroxylamine

2-phenyl-4-(4-methoxyphenyl)-2-hydroxy-5-oxo-1,2,3,4,5,6,7,8-octahydroquinoline

4-(4-Methoxy-phenyl)-2-phenyl-2,3,4,6,7,8-hexahydro-chromen-5-one