959-23-9

Usage

Uses

Used in Pharmaceutical Industry:
4'-METHOXYCHALCONE is used as a precursor in the synthesis of 3-(4-methoxy-phenyl)-3-morpholin-4-yl-1-phenyl-propan-1-one, a compound with potential pharmaceutical applications. The reaction involves the use of morpholine as a reactant and heptanes as a solvent, which allows for the formation of the desired product through a condensation process.
This application highlights the importance of 4'-METHOXYCHALCONE in the development of new drugs and therapeutic agents, as its reactivity and structural features can be exploited to create a wide range of bioactive molecules. By serving as a versatile precursor, 4'-METHOXYCHALCONE contributes to the advancement of pharmaceutical research and the discovery of innovative treatments for various diseases and conditions.

Upstream product

• 102-92-1 cinnamoyl chloride 
• 100-66-3 methoxybenzene 
• 100-52-7 benzaldehyde 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 138711-20-3 1-(4-Methoxy-phenyl)-2-[2-(4-methoxy-phenyl)-2-oxo-ethanesulfinyl]-ethanone 
• 17638-55-0 P-phenacyltriphenylphosphonium cation 
• 123-11-5 4-methoxy-benzaldehyde 
• 5962-06-1 N-formamido-3-phenyl-2-propenamide 
• 13677-45-7 1-(4-methoxyphenyl)-3-phenylprop-2-en-1-ol 
• 6097-26-3 p-methoxyphenacyl thiocyanate 
• 875877-84-2 [[1-(4-methoxyphenyl)-3-phenyl-2-propynyl]oxy]-trimethylsilane 
• 100-07-2 4-methoxy-benzoyl chloride 
• 536-74-3 phenylacetylene 
• 100-42-5 styrene 

Downstream Products

• 5338-59-0 5-(4-methoxy-phenyl)-5-oxo-2,3-diphenyl-valeronitrile 
• 95489-62-6 5-(4-methoxy-phenyl)-2-(4-nitro-phenyl)-5-oxo-3-phenyl-valeronitrile 
• 63688-29-9 5-(4-methoxy-phenyl)-1,3-diphenyl-pent-2-ene-1,5-dione 
• 186083-47-6 1,3-bis(4-methoxyphenyl)-3-phenylpropan-1-one 
• 500550-52-7 1-(4-methoxy-phenyl)-4-nitro-3,4-diphenyl-butan-1-one 
• 636987-22-9 (+/-)-1-(4-methoxyphenyl)-3-phenyl-pentan-1-one 
• 2657-24-1 1-(4-methoxyphenyl)-3,3-diphenylpropan-1-one 
• 171860-04-1 [3-(4-methoxy-phenyl)-3-oxo-1-phenyl-propyl]-malonic acid diethyl ester 
• 5739-38-8 1-(4-methoxyphenyl)-3-phenylpropan-1-one 
• 7145-87-1 2,3-dibromo-1-(4-methoxyphenyl)-3-phenylpropan-1-one 
• 20080-08-4 3-(4-methoxyphenyl)-5-phenyl-4,5-dihydroisoxazole 
• 201545-01-9 1-acetyl-3-(4-methoxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazole 
• 111505-36-3 1,6-bis-(4-methoxy-phenyl)-3,4-diphenyl-hexane-1,6-dione 
• 10226-02-5 1-p-Anisyl-4-isopropyl-7-methyl-3-phenyloctan-1,5-dion 

Relevant academic research and scientific papers

New pyrimidine derivatives as efficient organic inhibitors on mild steel corrosion in acidic medium: Electrochemical, SEM, EDX, AFM and DFT studies

New pyrimidine derivatives, namely, 7-methoxypyrido [2,3-d]pyrimidin-4-amine (MPPA) and 4-amino-7-methoxypyrido[2,3-d]pyrimidin-2(1H)-one (AMPO) were synthesized and their inhibitive action against the corrosion of mild steel in 15% HCl solution was studi

Synthesis of lithium/cesium-Zagronas from zagrosian natural asphalt and study of their activity as novel, green, heterogeneous and homogeneous nanocatalysts in the Claisen–Schmidt and Knoevenagel condensations

A novel, heterogeneous and homogeneous basic nanocatalysts were synthesized by grafting of lithium and cesium on zagrosian natural asphalt sulfonate (Li/Cs-Zagronas). The activity of these catalysts was examined in the Claisen–Schmidt and Knoevenagel condensations under mild reaction conditions. Li/Cs-Zagronas were characterized by FT-IR spectroscopy, scanning electron microscopy, X-ray diffraction, energy-dispersive spectroscopy, inductively coupled plasma and thermogravimetric analysis techniques. These nanocatalysts were removed by simple filtration and reused several times without any deterioration of activity.

Selective catalytic synthesis of α-alkylated ketones and β-disubstituted ketones via acceptorless dehydrogenative cross-coupling of alcohols

Herein, a phosphine-free pincer ruthenium(III) catalyzed β-alkylation of secondary alcohols with primary alcohols to α-alkylated ketones and two different secondary alcohols to β-branched ketones are reported. Notably, this transformation is environmentally benign and atom efficient with H2O and H2 gas as the only byproducts. The protocol is extended to gram-scale reaction and for functionalization of complex vitamin E and cholesterol derivatives.

Activated charcoal-mediated synthesis of chalcones catalyzed by NaOH in water

A variety of chalcones were synthesized in good yields by the activated charcoal-mediated aldol reactions between benzaldehydes and acetophenones catalyzed by NaOH in water. 2,6-Bis((E)-benzylidene)cyclohexan-1-ones were prepared by the aldol reactions between benzaldehydes and cyclohexanone. Activated charcoal could be recycled five times without the significant decrease of yields.

Synthesis of chalcone derivatives by phthalhydrazide-functionalized tio2-coated nano-fe3o4 as a new heterogeneous catalyst

Phthalhydrazide immobilized on TiO2-coated nano Fe3O4 (Fe3O4-P) was synthesized and characterized by FT-IR, XRD, SEM, EDS and VSM analysis. The resulting magnetic nanocatalyst was used as a catalyst for the synthesis of chalcone derivatives which affords the desired products in good to excellent yields. This catalyst can be isolated readily after completion of the reaction by an external magnetite field and reused several times without significant loss of activity.

Iridium and copper supported on silicon dioxide as chemoselective catalysts for dehydrogenation and borrowing hydrogen reactions

High active ligand usually plays an important role during catalysis and synthesis chemistry. A new and efficient benzotriazole-pyridinyl-silane ligand (BPS) was designed, and the corresponding iridium and copper catalysts were synthesized and thoroughly characterized by means of EDS, TEM, and XPS. The resulting iridium composite revealed excellent catalytic activity for the reaction of tert-butanesulfinamide with benzyl alcohols, while copper catalyst could realize the synthesis of unsaturated carbonyl compounds through the reaction of benzyl alcohols with ketones. This provided an efficient method for selective synthesis of unsaturated carbonyl compounds from benzyl alcohols and ketones in high yields with good recovery performance.

A Remote ‘Imidazole’-Based Ruthenium(II) Para-Cymene Pre-catalyst for the Selective Oxidation Reaction of Alkyl Arenes and Alcohols

Herein we disclosed the use of a remote ‘imidazole’-based precatalyst [(para-cymene)RuII(L)Cl]+, C-1 where L=2-(4-substituted-phenyl)-1H-imidazo[4,5-f][1,10] phenanthroline) for the selective oxidation of a variety of alkyl arenes/heteroarenes and alcohols to their corresponding aldehydes or ketones in presence of tert-butyl hydroperoxide (TBHP). The remote ‘imidazole’ moiety present in the complex facilitates the activation of oxidant and subsequent generation of active species via the release of para-cymene from C-1, which in-turn was less effective without the ‘imidazole’ moiety. The mechanistic features of C-1 promoted oxidation of alkyl arenes were also assessed from spectroscopic, kinetic, and few control experiments. The substrate scope for C-1 promoted oxidation reaction was assessed based on the selective oxidation of 27-different alkyl arenes/heteroarenes and 25 different alcohols to their corresponding aldehydes/ketones in moderate to good yields.

Potassium Natural Asphalt Sulfonate (K-NAS): Synthesis and characterization as a new recyclable solid basic nanocatalyst and its application in the formation of carbon–carbon bonds

In this research, we synthesized and characterized a new heterogeneous basic nanocatalyst and its catalytic application was studied in the Claisen-Schmidt and Knoevenagel condensations. In order to prepare this nanocatalyst, first, the Iranian natural asphalt was sulfonated with the concentrated sulfuric acid and then, converted to the potassium natural asphalt sulfonate (K-NAS). In order to characterization of the nanocatalyst, used of FT-IR spectroscopy, scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), inductively coupled plasma (ICP) and thermogravimetric analysis (TGA) techniques. This new basic heterogeneous nanocatalyst have advantages such as being eco-friendly, huge specific surface area, high reactivity and recyclability.

Hydroxychalcone dyes that serve as color indicators for pH and fluoride ions

A chalcone, which is composed of two aromatic rings bridged by an α,β-unsaturated carbonyl group, exhibits a variety of biological activities. With an objective to develop a novel chalcone-based functional dye, we have synthesized a chalcone diol CLN1, bearing two OH groups at the 2-positions on both phenyl rings, as well as reference compounds CLN2-6, and found that it serves as color indicators for pH and fluoride ions. CLN1showed a vivid color change from colorless to yellow (halochromism) in water at pH ≥ 10. Furthermore, it presented a selective color change from colorless to red upon the addition of TBAF in an organic solvent such as CH3CN. CLN1provided a strong red-shifted absorption band in the visible region under alkaline conditions in water and upon the addition of TBAF in CH3CN. The absorption spectral study together with TD-DFT calculations and X-ray crystallographic analysis revealed that the characteristic π-resonant structures of CLN1caused by the ionization or OH-F?interactions and the planar conformation due to its intramolecular hydrogen bonding may provide a strong charge transfer (CT) absorption in the visible region.

β-Carbolines: synthesis of harmane, harmine alkaloids and their structural analogs by thermolysis of 4-aryl-3-azidopyridines and investigation of their optical properties

[Figure not available: see fulltext.] Interest in β-carbolines is caused by the biological activity of these compounds and the use of their fluorescent properties in the study of their interaction with DNA and other biological targets, as well as with drug delivery vehicles. A new general method for the synthesis of harmane, harmine, and their structural analogs by thermolysis of substituted 4-aryl-3-azidopyridines was developed, and their optical properties were studied.