3-bromo-N-[2-[3-(2,2-dimethylpropanoylamino)-4-methylphenyl]imidazo[2,1-f]pyridazin-6-yl]benzamide

Base Information

Chemical Name:3-bromo-N-[2-[3-(2,2-dimethylpropanoylamino)-4-methylphenyl]imidazo[2,1-f]pyridazin-6-yl]benzamide
CAS No.:1383622-73-8
Molecular Formula:C₂₅H₂₄BrN₅O₂
Molecular Weight:506.402
Hs Code.:

Synonyms:3-bromo-N-[2-[3-(2,2-dimethylpropanoylamino)-4-methylphenyl]imidazo[2,1-f]pyridazin-6-yl]benzamide

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Chemical Property of 3-bromo-N-[2-[3-(2,2-dimethylpropanoylamino)-4-methylphenyl]imidazo[2,1-f]pyridazin-6-yl]benzamide

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Technology Process of 3-bromo-N-[2-[3-(2,2-dimethylpropanoylamino)-4-methylphenyl]imidazo[2,1-f]pyridazin-6-yl]benzamide

There total 7 articles about 3-bromo-N-[2-[3-(2,2-dimethylpropanoylamino)-4-methylphenyl]imidazo[2,1-f]pyridazin-6-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1711-09-7
3-bromobenzoyl chloride

: 1383622-72-7
N-[5-(6-aminoimidazo[2,1-f]pyridazin-2-yl)-2-methylphenyl]-2,2-dimethylpropanamide

: 1383622-73-8
3-bromo-N-[2-[3-(2,2-dimethylpropanoylamino)-4-methylphenyl]imidazo[2,1-f]pyridazin-6-yl]benzamide

Guidance literature:: With pyridine; In acetonitrile; at 20 ℃; for 16h;

Reference yield:

: 5337-93-9
4'-methylpropiophenone

: 1383622-73-8
3-bromo-N-[2-[3-(2,2-dimethylpropanoylamino)-4-methylphenyl]imidazo[2,1-f]pyridazin-6-yl]benzamide

Guidance literature:: Multi-step reaction with 8 steps

1: nitric acid / 0 - 10 °C

2: bromine / dichloromethane / 20 °C

3: acetonitrile / 16 h / 80 °C

4: acetic acid; iron / ethanol; water / 6 h / 80 °C

5: pyridine / acetonitrile / 4 h / 20 °C

6: sodium t-butanolate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / toluene / 1 h / 100 °C / Inert atmosphere

7: trifluoroacetic acid / 16 h / 50 °C

8: pyridine / acetonitrile / 16 h / 20 °C

With pyridine; bromine; nitric acid; iron; acetic acid; trifluoroacetic acid; sodium t-butanolate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In ethanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 50630-41-6
1-(4'-methyl-3'-nitrophenyl)-propane-1-one

: 1383622-73-8
3-bromo-N-[2-[3-(2,2-dimethylpropanoylamino)-4-methylphenyl]imidazo[2,1-f]pyridazin-6-yl]benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: bromine / dichloromethane / 20 °C

2: acetonitrile / 16 h / 80 °C

3: acetic acid; iron / ethanol; water / 6 h / 80 °C

4: pyridine / acetonitrile / 4 h / 20 °C

5: sodium t-butanolate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / toluene / 1 h / 100 °C / Inert atmosphere

6: trifluoroacetic acid / 16 h / 50 °C

7: pyridine / acetonitrile / 16 h / 20 °C

With pyridine; bromine; iron; acetic acid; trifluoroacetic acid; sodium t-butanolate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In ethanol; dichloromethane; water; toluene; acetonitrile;