N-[5-(6-aminoimidazo[2,1-f]pyridazin-2-yl)-2-methylphenyl]-2,2-dimethylpropanamide

Base Information

Chemical Name:N-[5-(6-aminoimidazo[2,1-f]pyridazin-2-yl)-2-methylphenyl]-2,2-dimethylpropanamide
CAS No.:1383622-72-7
Molecular Formula:C₁₈H₂₁N₅O
Molecular Weight:323.398
Hs Code.:

Synonyms:N-[5-(6-aminoimidazo[2,1-f]pyridazin-2-yl)-2-methylphenyl]-2,2-dimethylpropanamide

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Chemical Property of N-[5-(6-aminoimidazo[2,1-f]pyridazin-2-yl)-2-methylphenyl]-2,2-dimethylpropanamide

Chemical Property:

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Technology Process of N-[5-(6-aminoimidazo[2,1-f]pyridazin-2-yl)-2-methylphenyl]-2,2-dimethylpropanamide

There total 7 articles about N-[5-(6-aminoimidazo[2,1-f]pyridazin-2-yl)-2-methylphenyl]-2,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383622-71-6
N-(2-methyl-5-(6-(3,4,5-trimethoxybenzylamino)imidazo[1,2-b]pyridazin-2-yl)phenyl)pivalamide

: 1383622-72-7
N-[5-(6-aminoimidazo[2,1-f]pyridazin-2-yl)-2-methylphenyl]-2,2-dimethylpropanamide

Guidance literature:: With trifluoroacetic acid; at 50 ℃; for 16h;

Reference yield:

: 5337-93-9
4'-methylpropiophenone

: 1383622-72-7
N-[5-(6-aminoimidazo[2,1-f]pyridazin-2-yl)-2-methylphenyl]-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 7 steps

1: nitric acid / 0 - 10 °C

2: bromine / dichloromethane / 20 °C

3: acetonitrile / 16 h / 80 °C

4: acetic acid; iron / ethanol; water / 6 h / 80 °C

5: pyridine / acetonitrile / 4 h / 20 °C

6: sodium t-butanolate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / toluene / 1 h / 100 °C / Inert atmosphere

7: trifluoroacetic acid / 16 h / 50 °C

With pyridine; bromine; nitric acid; iron; acetic acid; trifluoroacetic acid; sodium t-butanolate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In ethanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1383625-05-5
2-bromo-1-(4-methyl-3-nitrophenyl)propan-1-one

: 1383622-72-7
N-[5-(6-aminoimidazo[2,1-f]pyridazin-2-yl)-2-methylphenyl]-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1: acetonitrile / 16 h / 80 °C

2: acetic acid; iron / ethanol; water / 6 h / 80 °C

3: pyridine / acetonitrile / 4 h / 20 °C

4: sodium t-butanolate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / toluene / 1 h / 100 °C / Inert atmosphere

5: trifluoroacetic acid / 16 h / 50 °C

With pyridine; iron; acetic acid; trifluoroacetic acid; sodium t-butanolate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In ethanol; water; toluene; acetonitrile;