tert-butyl 1-(6-(2-amino-4-nitrophenyl)-3-chloropyridazin-4-yl)but-3-enylcarbamate

Base Information

Chemical Name:tert-butyl 1-(6-(2-amino-4-nitrophenyl)-3-chloropyridazin-4-yl)but-3-enylcarbamate
CAS No.:1329167-98-7
Molecular Formula:C₁₉H₂₂ClN₅O₄
Molecular Weight:419.868
Hs Code.:

Synonyms:tert-butyl 1-(6-(2-amino-4-nitrophenyl)-3-chloropyridazin-4-yl)but-3-enylcarbamate

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Chemical Property of tert-butyl 1-(6-(2-amino-4-nitrophenyl)-3-chloropyridazin-4-yl)but-3-enylcarbamate

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Technology Process of tert-butyl 1-(6-(2-amino-4-nitrophenyl)-3-chloropyridazin-4-yl)but-3-enylcarbamate

There total 3 articles about tert-butyl 1-(6-(2-amino-4-nitrophenyl)-3-chloropyridazin-4-yl)but-3-enylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1329166-69-9
2‐(5,5‐dimethyl‐1,3,2‐dioxaborinan‐2‐yl)‐5‐nitroaniline

: 1329167-97-6
tert-butyl 1-(3,6-dichloropyridazin-4-yl)but-3-enylcarbamate

: 1329167-98-7
tert-butyl 1-(6-(2-amino-4-nitrophenyl)-3-chloropyridazin-4-yl)but-3-enylcarbamate

Guidance literature:: With caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 90 ℃; for 3h; Inert atmosphere;

Reference yield:

: 10403-47-1
2-bromo 5-nitroaniline

: 1329167-98-7
tert-butyl 1-(6-(2-amino-4-nitrophenyl)-3-chloropyridazin-4-yl)but-3-enylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 4 h / 80 °C / Inert atmosphere

2: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 3 h / 90 °C / Inert atmosphere

With potassium carbonate; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dimethyl sulfoxide;

Reference yield:

: 631914-72-2
tert-butyl N-[(3,6-dichloropyridazin-4-yl)methyl]carbamate

: 1329167-98-7
tert-butyl 1-(6-(2-amino-4-nitrophenyl)-3-chloropyridazin-4-yl)but-3-enylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / cyclohexane; tetrahydrofuran / 0.5 h / -78 - -40 °C

1.2: 0.5 h / -78 °C

2.1: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 3 h / 90 °C / Inert atmosphere

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; cyclohexane;