trans-4-((5-(2-((3-methoxybenzyl)carbamoyl)-6-methyl-pyridin-4-yl)-2H-tetrazol-2-yl)methyl)cyclohexanecarboxylic acid

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Chemical Name:trans-4-((5-(2-((3-methoxybenzyl)carbamoyl)-6-methyl-pyridin-4-yl)-2H-tetrazol-2-yl)methyl)cyclohexanecarboxylic acid
CAS No.:1112173-02-0
Molecular Formula:C₂₄H₂₈N₆O₄
Molecular Weight:464.524
Hs Code.:

Synonyms:trans-4-((5-(2-((3-methoxybenzyl)carbamoyl)-6-methyl-pyridin-4-yl)-2H-tetrazol-2-yl)methyl)cyclohexanecarboxylic acid

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Chemical Property of trans-4-((5-(2-((3-methoxybenzyl)carbamoyl)-6-methyl-pyridin-4-yl)-2H-tetrazol-2-yl)methyl)cyclohexanecarboxylic acid

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Technology Process of trans-4-((5-(2-((3-methoxybenzyl)carbamoyl)-6-methyl-pyridin-4-yl)-2H-tetrazol-2-yl)methyl)cyclohexanecarboxylic acid

There total 8 articles about trans-4-((5-(2-((3-methoxybenzyl)carbamoyl)-6-methyl-pyridin-4-yl)-2H-tetrazol-2-yl)methyl)cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1112173-00-8
trans-methyl 4-((5-(2-((3-methoxybenzyl)carbamoyl)-6-methylpyridin-4-yl)-2H-tetrazol-2-yl)methyl)cyclohexanecarboxylate

: 1112173-02-0
trans-4-((5-(2-((3-methoxybenzyl)carbamoyl)-6-methyl-pyridin-4-yl)-2H-tetrazol-2-yl)methyl)cyclohexanecarboxylic acid

Guidance literature:: With sodium hydroxide; water; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 25462-85-5
2-chloro-6-methylpyridine-4-carboxylic acid

: 1112173-02-0
trans-4-((5-(2-((3-methoxybenzyl)carbamoyl)-6-methyl-pyridin-4-yl)-2H-tetrazol-2-yl)methyl)cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 15 h / 20 °C

2: dichloromethane / 15 h / 20 °C

3: trichlorophosphate / toluene / 15 h / 110 °C

4: triethylamine hydrochloride; sodium azide / toluene / 4 h / Reflux

5: triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate / 24 h / 100 °C / 6205.94 - 9826.07 Torr

6: 1 h / 100 °C / Inert atmosphere

7: di-tert-butyl-diazodicarboxylate / tetrahydrofuran

With 1,1'-bis-(diphenylphosphino)ferrocene; sodium azide; oxalyl dichloride; di-tert-butyl-diazodicarboxylate; palladium diacetate; triethylamine hydrochloride; triethylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/acs.jmedchem.5b01434

Reference yield:

: 26413-58-1
2-chloro-6-methyl-4-pyridinecarbonyl chloride

: 1112173-02-0
trans-4-((5-(2-((3-methoxybenzyl)carbamoyl)-6-methyl-pyridin-4-yl)-2H-tetrazol-2-yl)methyl)cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: dichloromethane / 15 h / 20 °C

2: trichlorophosphate / toluene / 15 h / 110 °C

3: triethylamine hydrochloride; sodium azide / toluene / 4 h / Reflux

4: triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate / 24 h / 100 °C / 6205.94 - 9826.07 Torr

5: 1 h / 100 °C / Inert atmosphere

6: di-tert-butyl-diazodicarboxylate / tetrahydrofuran

With 1,1'-bis-(diphenylphosphino)ferrocene; sodium azide; di-tert-butyl-diazodicarboxylate; palladium diacetate; triethylamine hydrochloride; triethylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/acs.jmedchem.5b01434