trans-methyl 4-((5-(2-((3-methoxybenzyl)carbamoyl)-6-methylpyridin-4-yl)-2H-tetrazol-2-yl)methyl)cyclohexanecarboxylate

Base Information

Chemical Name:trans-methyl 4-((5-(2-((3-methoxybenzyl)carbamoyl)-6-methylpyridin-4-yl)-2H-tetrazol-2-yl)methyl)cyclohexanecarboxylate
CAS No.:1112173-00-8
Molecular Formula:C₂₅H₃₀N₆O₄
Molecular Weight:478.551
Hs Code.:

Synonyms:trans-methyl 4-((5-(2-((3-methoxybenzyl)carbamoyl)-6-methylpyridin-4-yl)-2H-tetrazol-2-yl)methyl)cyclohexanecarboxylate

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Chemical Property of trans-methyl 4-((5-(2-((3-methoxybenzyl)carbamoyl)-6-methylpyridin-4-yl)-2H-tetrazol-2-yl)methyl)cyclohexanecarboxylate

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Technology Process of trans-methyl 4-((5-(2-((3-methoxybenzyl)carbamoyl)-6-methylpyridin-4-yl)-2H-tetrazol-2-yl)methyl)cyclohexanecarboxylate

There total 8 articles about trans-methyl 4-((5-(2-((3-methoxybenzyl)carbamoyl)-6-methylpyridin-4-yl)-2H-tetrazol-2-yl)methyl)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 110928-44-4
trans-(4-hydroxymethyl)cyclohexane-1-carboxylic acid methyl ester

: 1112181-71-1
N-(3-methoxybenzyl)-6-methyl-4-(2H-tetrazol-5-yl)picolinamide

: 1112173-00-8
trans-methyl 4-((5-(2-((3-methoxybenzyl)carbamoyl)-6-methylpyridin-4-yl)-2H-tetrazol-2-yl)methyl)cyclohexanecarboxylate

Guidance literature:: With PS-triphenylphosphine; di-tert-butyl-diazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; for 2.16667h;

Reference yield:

: 5071-96-5
3-METHOXYBENZYLAMINE

: 1112182-58-7
methyl 4-(2-((trans-4-(methoxycarbonyl)cyclohexyl)methyl)-2H-tetrazol-5-yl)-6-methylpicolinate

: 1112173-00-8
trans-methyl 4-((5-(2-((3-methoxybenzyl)carbamoyl)-6-methylpyridin-4-yl)-2H-tetrazol-2-yl)methyl)cyclohexanecarboxylate

Guidance literature:: In N,N-dimethyl-formamide; at 60 ℃; for 72h;
DOI:10.1016/j.bmcl.2009.11.081

Reference yield:

: 25462-85-5
2-chloro-6-methylpyridine-4-carboxylic acid

: 1112173-00-8
trans-methyl 4-((5-(2-((3-methoxybenzyl)carbamoyl)-6-methylpyridin-4-yl)-2H-tetrazol-2-yl)methyl)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 15 h / 20 °C

2: dichloromethane / 15 h / 20 °C

3: trichlorophosphate / toluene / 15 h / 110 °C

4: triethylamine hydrochloride; sodium azide / toluene / 4 h / Reflux

5: triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate / 24 h / 100 °C / 6205.94 - 9826.07 Torr

6: 1 h / 100 °C / Inert atmosphere

7: di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 18 h

With 1,1'-bis-(diphenylphosphino)ferrocene; sodium azide; oxalyl dichloride; di-tert-butyl-diazodicarboxylate; palladium diacetate; triethylamine hydrochloride; triethylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/acs.jmedchem.5b01434