methyl 3-cyclopropylcarboxamido-5-methyl-1-phenyl-4-pyrazolecarboxylate

Base Information

• Chemical Name: methyl 3-cyclopropylcarboxamido-5-methyl-1-phenyl-4-pyrazolecarboxylate
• CAS No.: 268544-98-5
• Molecular Formula: C₁₆H₁₇N₃O₃
• Molecular Weight: 299.329
• Mol file: 268544-98-5.mol

Synonyms:methyl 3-cyclopropylcarboxamido-5-methyl-1-phenyl-4-pyrazolecarboxylate

Chemical Property of methyl 3-cyclopropylcarboxamido-5-methyl-1-phenyl-4-pyrazolecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl 3-cyclopropylcarboxamido-5-methyl-1-phenyl-4-pyrazolecarboxylate

There total 3 articles about methyl 3-cyclopropylcarboxamido-5-methyl-1-phenyl-4-pyrazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cyclopropylamine (765-30-0) + 3-chlorocarbonyl-5-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid methyl ester (1026593-28-1) → methyl 3-cyclopropylcarboxamido-5-methyl-1-phenyl-4-pyrazolecarboxylate (268544-98-5)

Guidance literature:

With sodium hydrogencarbonate; In chloroform; at 20 ℃; for 4h;

DOI:10.1002/jhet.5570370129

Reference yield:

5-methyl-1-phenylpyrazole-3,4-dicarboxylic acid-3-ethyl-4-methyl ester (198135-19-2) → methyl 3-cyclopropylcarboxamido-5-methyl-1-phenyl-4-pyrazolecarboxylate (268544-98-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1M aq. KOH / methanol / 24 h / 0 °C

2: PCl₅ / diethyl ether / 1 h / 0 °C

3: aq. NaHCO₃ / CHCl₃ / 4 h / 20 °C

With potassium hydroxide; phosphorus pentachloride; sodium hydrogencarbonate; In methanol; diethyl ether; chloroform; 1: Hydrolysis / 2: Chlorination / 3: Acylation;

DOI:10.1002/jhet.5570370129

Reference yield:

4-(methoxycarbonyl)-5-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid (198135-47-6) → methyl 3-cyclopropylcarboxamido-5-methyl-1-phenyl-4-pyrazolecarboxylate (268544-98-5)

Guidance literature:

Multi-step reaction with 2 steps

1: PCl₅ / diethyl ether / 1 h / 0 °C

2: aq. NaHCO₃ / CHCl₃ / 4 h / 20 °C

With phosphorus pentachloride; sodium hydrogencarbonate; In diethyl ether; chloroform; 1: Chlorination / 2: Acylation;

DOI:10.1002/jhet.5570370129

upstream raw materials:

Cyclopropylamine

3-chlorocarbonyl-5-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid methyl ester

4-(methoxycarbonyl)-5-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid

5-methyl-1-phenylpyrazole-3,4-dicarboxylic acid-3-ethyl-4-methyl ester