N-(1-(4-(1-(4-(cyclopropylmethoxy)phenyl)azetidin-3-yloxy)-3-fluorophenyl)ethyl)-acetamide

Base Information

Chemical Name:N-(1-(4-(1-(4-(cyclopropylmethoxy)phenyl)azetidin-3-yloxy)-3-fluorophenyl)ethyl)-acetamide
CAS No.:1443670-27-6
Molecular Formula:C₂₃H₂₇FN₂O₃
Molecular Weight:398.477
Hs Code.:

Synonyms:N-(1-(4-(1-(4-(cyclopropylmethoxy)phenyl)azetidin-3-yloxy)-3-fluorophenyl)ethyl)-acetamide

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Chemical Property of N-(1-(4-(1-(4-(cyclopropylmethoxy)phenyl)azetidin-3-yloxy)-3-fluorophenyl)ethyl)-acetamide

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Technology Process of N-(1-(4-(1-(4-(cyclopropylmethoxy)phenyl)azetidin-3-yloxy)-3-fluorophenyl)ethyl)-acetamide

There total 11 articles about N-(1-(4-(1-(4-(cyclopropylmethoxy)phenyl)azetidin-3-yloxy)-3-fluorophenyl)ethyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443670-63-0
N-[1-(4-hydroxy-3-fluoro-phenyl)-ethyl]-acetamide

: 1443670-65-2
1-(4-(cyclopropylmethoxy)phenyl)azetidin-3-ol

: 1443670-27-6
N-(1-(4-(1-(4-(cyclopropylmethoxy)phenyl)azetidin-3-yloxy)-3-fluorophenyl)ethyl)-acetamide

Guidance literature:: With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 60 ℃;

Reference yield:

: 1443670-63-0
N-[1-(4-hydroxy-3-fluoro-phenyl)-ethyl]-acetamide

: 1443670-67-4
1-(4-(cyclopropylmethoxy)phenyl)azetidin-3-yl methanesulfonate

: 1443670-27-6
N-(1-(4-(1-(4-(cyclopropylmethoxy)phenyl)azetidin-3-yloxy)-3-fluorophenyl)ethyl)-acetamide

Guidance literature:: With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; at 60 ℃;

Reference yield:

: 133059-43-5
4-bromo-3-fluorobenzaldehyde

: 1443670-27-6
N-(1-(4-(1-(4-(cyclopropylmethoxy)phenyl)azetidin-3-yloxy)-3-fluorophenyl)ethyl)-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 1.5 h / 50 °C

2.1: tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h

4.1: pyridine / dichloromethane / 12 h / 20 °C

5.1: 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium hydroxide / 1,4-dioxane; water / 0.17 h / 140 °C / Inert atmosphere; Microwave irradiation

6.1: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / 60 °C

With 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; pyridine; hydrogenchloride; titanium(IV) tetraethanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; di-tert-butyl-diazodicarboxylate; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 6.1: |Mitsunobu Displacement;