(1R,3S)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)cyclohexane-1-carboxylic acid

Base Information

Chemical Name:(1R,3S)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)cyclohexane-1-carboxylic acid
CAS No.:1259367-00-4
Molecular Formula:C₁₁H₁₃ClFN₃O₂
Molecular Weight:273.695
Hs Code.:

Synonyms:(1R,3S)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)cyclohexane-1-carboxylic acid

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Chemical Property of (1R,3S)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)cyclohexane-1-carboxylic acid

Chemical Property:

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Technology Process of (1R,3S)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)cyclohexane-1-carboxylic acid

There total 5 articles about (1R,3S)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)cyclohexane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: LiOH hydrate

: 1259366-99-8
ethyl (1R,3S)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)cyclohexane-1-carboxylate

: 1259367-00-4
(1R,3S)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)cyclohexane-1-carboxylic acid

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

: 227783-08-6
(1S,3R)-3-ethoxycarbonylcyclohexane-1-carboxylic acid

: 1259367-00-4
(1R,3S)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)cyclohexane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 110 °C

1.2: 70 - 85 °C

2.1: palladium on activated charcoal / ethanol / 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Reflux

4.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 50 °C

With lithium hydroxide monohydrate; diphenyl phosphoryl azide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; toluene;

Reference yield:

: 1259278-09-5
ethyl (1R,3S)-3-benzyloxycarbonylaminocyclohexane-1-carboxylate

: 1259367-00-4
(1R,3S)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)cyclohexane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: palladium on activated charcoal / ethanol / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Reflux

3: lithium hydroxide monohydrate / water; tetrahydrofuran / 50 °C

With lithium hydroxide monohydrate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; water;