N-((1R,3S)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)cyclohexyl)pyrrolidine-1-carboxamide

Base Information

Chemical Name:N-((1R,3S)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)cyclohexyl)pyrrolidine-1-carboxamide
CAS No.:1259367-01-5
Molecular Formula:C₁₅H₂₁ClFN₅O
Molecular Weight:341.816
Hs Code.:

Synonyms:N-((1R,3S)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)cyclohexyl)pyrrolidine-1-carboxamide

Suppliers and Price of N-((1R,3S)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)cyclohexyl)pyrrolidine-1-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((1R,3S)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)cyclohexyl)pyrrolidine-1-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-((1R,3S)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)cyclohexyl)pyrrolidine-1-carboxamide

There total 7 articles about N-((1R,3S)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)cyclohexyl)pyrrolidine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 123-75-1
pyrrolidine

: 1259367-00-4
(1R,3S)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)cyclohexane-1-carboxylic acid

: 1259367-01-5
N-((1R,3S)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)cyclohexyl)pyrrolidine-1-carboxamide

Guidance literature:: (1R,3S)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)cyclohexane-1-carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In tetrahydrofuran; at 85 ℃; for 1.5h; Inert atmosphere;

pyrrolidine; In tetrahydrofuran; at 85 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.6b00487

Reference yield:

: 123-75-1
pyrrolidine

: 26386-88-9
diphenyl phosphoryl azide

: 1259367-00-4
(1R,3S)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)cyclohexane-1-carboxylic acid

: 1259367-01-5
N-((1R,3S)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)cyclohexyl)pyrrolidine-1-carboxamide

Guidance literature:: With triethylamine; In tetrahydrofuran;

Reference yield:

: 227783-08-6
(1S,3R)-3-ethoxycarbonylcyclohexane-1-carboxylic acid

: 1259367-01-5
N-((1R,3S)-3-((2-chloro-5-fluoropyrimidin-4-yl)amino)cyclohexyl)pyrrolidine-1-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 110 °C

1.2: 70 - 85 °C

2.1: palladium on activated charcoal / ethanol / 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Reflux

4.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 50 °C

5.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 0.75 h / 85 °C / Inert atmosphere

5.2: 0.25 h / 85 °C

With lithium hydroxide monohydrate; diphenyl phosphoryl azide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; toluene;