5-chloro-N₄-cyclopropyl-N₂-{3-[1-(3-methoxypropoxy)ethyl]phenyl}pyrimidine-2,4-diamine

Base Information

• Chemical Name: 5-chloro-N₄-cyclopropyl-N₂-{3-[1-(3-methoxypropoxy)ethyl]phenyl}pyrimidine-2,4-diamine
• CAS No.: 1215308-69-2
• Molecular Formula: C₁₉H₂₅ClN₄O₂
• Molecular Weight: 376.886

Synonyms:5-chloro-N₄-cyclopropyl-N₂-{3-[1-(3-methoxypropoxy)ethyl]phenyl}pyrimidine-2,4-diamine

Chemical Property of 5-chloro-N₄-cyclopropyl-N₂-{3-[1-(3-methoxypropoxy)ethyl]phenyl}pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of 5-chloro-N₄-cyclopropyl-N₂-{3-[1-(3-methoxypropoxy)ethyl]phenyl}pyrimidine-2,4-diamine

There total 2 articles about 5-chloro-N₄-cyclopropyl-N₂-{3-[1-(3-methoxypropoxy)ethyl]phenyl}pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methoxypropanol (1589-49-7) + 1-(3-{[5-chloro-4-(cyclopropylamino)pyrimidin-2-yl]amino}phenyl)ethanol (1215309-04-8) → 5-chloro-N4-cyclopropyl-N2-{3-[1-(3-methoxypropoxy)ethyl]phenyl}pyrimidine-2,4-diamine (1215308-69-2)

Guidance literature:

methoxypropanol; 1-(3-{[5-chloro-4-(cyclopropylamino)pyrimidin-2-yl]amino}phenyl)ethanol; With cerium (IV) sulfate tetrahydrate; toluene-4-sulfonic acid; at 150 ℃; for 20h;

With sodium hydrogencarbonate; In water;

Reference yield:

2,5-dichloro-N-cyclopropylpyrimidin-4-amine (1050602-55-5) + 3-(1-hydroxyethyl)aniline (2454-37-7) → 5-chloro-N4-cyclopropyl-N2-{3-[1-(3-methoxypropoxy)ethyl]phenyl}pyrimidine-2,4-diamine (1215308-69-2)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 1,4-dioxane / 16 h / 100 °C

2: cerium (IV) sulfate tetrahydrate; toluene-4-sulfonic acid / 20 h / 150 °C

With cerium (IV) sulfate tetrahydrate; toluene-4-sulfonic acid; In 1,4-dioxane;

upstream raw materials:

methoxypropanol

1-(3-{[5-chloro-4-(cyclopropylamino)pyrimidin-2-yl]amino}phenyl)ethanol

2,5-dichloro-N-cyclopropylpyrimidin-4-amine

3-(1-hydroxyethyl)aniline

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