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1589-49-7

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1589-49-7 Usage

Chemical Properties

Colorless liqui

General Description

3-Methoxy-1-propanol is a primary alcohol. Kinetics of the reactions of 3-methoxy-1-propanol with phenyl isocyanate in the presence of metal catalysts has been reported. Selective synthesis of 3-methoxy-1-propanol from methanol and allyl alcohol with metal oxides and zeolites catalysts in the liquid phase has been studied.

Check Digit Verification of cas no

The CAS Registry Mumber 1589-49-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,5,8 and 9 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1589-49:
(6*1)+(5*5)+(4*8)+(3*9)+(2*4)+(1*9)=107
107 % 10 = 7
So 1589-49-7 is a valid CAS Registry Number.
InChI:InChI=1/C4H10O2/c1-6-4-2-3-5/h5H,2-4H2,1H3

1589-49-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Methoxy-1-propanol

1.2 Other means of identification

Product number -
Other names 3-METHOXYPROPANE-1-OL

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1589-49-7 SDS

1589-49-7Synthetic route

methylallylether
627-40-7

methylallylether

methoxypropanol
1589-49-7

methoxypropanol

Conditions
ConditionsYield
Stage #1: methylallylether With diborane In dimethyl sulfoxide Inert atmosphere;
Stage #2: With dihydrogen peroxide; sodium hydroxide In dimethyl sulfoxide Reagent/catalyst; Solvent;
91.2%
methyl iodide
74-88-4

methyl iodide

trimethyleneglycol
504-63-2

trimethyleneglycol

methoxypropanol
1589-49-7

methoxypropanol

Conditions
ConditionsYield
With mercury(II) oxide In dichloromethane at 20℃; for 28h;72%
With sodium In octane
With potassium carbonate Multistep reaction;
1,3-dioxane
505-22-6

1,3-dioxane

methoxypropanol
1589-49-7

methoxypropanol

Conditions
ConditionsYield
With diisobutylaluminium hydride In benzene for 1h; Heating; further reagents: triethylaluminum, triisobutylaluminum with Pd(acac)2;65%
With lithium aluminium tetrahydride; boron trichloride 1.) CH2Cl2, 0.2 h, 2.) Et2O, 30 min; Yield given. Multistep reaction;
methyl 3-methoxypropionate
3852-09-3

methyl 3-methoxypropionate

methoxypropanol
1589-49-7

methoxypropanol

Conditions
ConditionsYield
Stage #1: methyl 3-methoxypropionate With lithium aluminium tetrahydride In diethyl ether for 4.5h; Inert atmosphere;
Stage #2: With water; sodium hydroxide In diethyl ether at 0 - 20℃;
60%
Stage #1: methyl 3-methoxypropionate With lithium aluminium tetrahydride In diethyl ether for 4.5h;
Stage #2: With sodium hydroxide; water In diethyl ether at 0℃;
60%
With hydrogen In methanol at 170℃; under 150015 Torr;51%
methanol
67-56-1

methanol

1-bromo-3-propanol
627-18-9

1-bromo-3-propanol

methoxypropanol
1589-49-7

methoxypropanol

Conditions
ConditionsYield
With sodium In methanol 1.) 20 deg. C, 1 h, 2.) reflux, 1 h;20%
trimethylene oxide
503-30-0

trimethylene oxide

methanol
67-56-1

methanol

methoxypropanol
1589-49-7

methoxypropanol

Conditions
ConditionsYield
With sulfuric acid
trimethylene oxide
503-30-0

trimethylene oxide

sodium methylate
124-41-4

sodium methylate

methoxypropanol
1589-49-7

methoxypropanol

Conditions
ConditionsYield
With methanol at 175℃;
3-methoxy-1-propanal
2806-84-0

3-methoxy-1-propanal

methoxypropanol
1589-49-7

methoxypropanol

Conditions
ConditionsYield
With methanol; pumice stone; nickel at 45 - 100℃; Hydrogenation;
With sodium metaborate In water
With hydrogen; nickel at 80℃; under 37503.8 Torr; for 3h;
With hydrogen; Ru/C under 37503.8 Torr; for 3h;
methanol
67-56-1

methanol

acrolein
107-02-8

acrolein

methoxypropanol
1589-49-7

methoxypropanol

Conditions
ConditionsYield
With sodium hydroxide; hydroquinone beim Ansaeuern mit Essigsaeure und anschliessenden Hydrieren an Raney-Nickel bei 93grad/70 at;
3-Methoxypropionitrile
110-67-8

3-Methoxypropionitrile

methoxypropanol
1589-49-7

methoxypropanol

Conditions
ConditionsYield
(i) EtOH, H2SO4, (ii) LiAlH4; Multistep reaction;
sodium methylate
124-41-4

sodium methylate

1-chloro-3-hydroxypropane
627-30-5

1-chloro-3-hydroxypropane

methoxypropanol
1589-49-7

methoxypropanol

Conditions
ConditionsYield
In methanol
tetrahydrofuran
109-99-9

tetrahydrofuran

A

trimethylene oxide
503-30-0

trimethylene oxide

B

methoxypropanol
1589-49-7

methoxypropanol

Conditions
ConditionsYield
With methane; water; oxygen Irradiation;
1,3-dioxane
505-22-6

1,3-dioxane

A

methoxypropanol
1589-49-7

methoxypropanol

B

trimethyleneglycol
504-63-2

trimethyleneglycol

Conditions
ConditionsYield
With lithium aluminium tetrahydride; boron tribromide 1.) CH2Cl2, 0 deg C, 0.03 h, 2.) Et2O, 30 min; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
3-bromopropanol methyl ether
36865-41-5

3-bromopropanol methyl ether

methoxypropanol
1589-49-7

methoxypropanol

Conditions
ConditionsYield
With water; triethylamine In ethanol at 124.8℃; Kinetics; further temperatures, further solvent, activation enthalpy and entropy;
methylallylether
627-40-7

methylallylether

A

propan-1-ol
71-23-8

propan-1-ol

B

1-methoxy-2-propanol
107-98-2

1-methoxy-2-propanol

C

methoxypropanol
1589-49-7

methoxypropanol

Conditions
ConditionsYield
With sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide Product distribution; 1) THF, 25 deg C, 2 h;A 1.5 % Chromat.
B n/a
C 94 % Chromat.
methylallylether
627-40-7

methylallylether

A

1-methoxy-2-propanol
107-98-2

1-methoxy-2-propanol

B

methoxypropanol
1589-49-7

methoxypropanol

Conditions
ConditionsYield
With sodium hydroxide; sodium tetrahydroborate; mercury(II) diacetate 1) water, THF, 30 min, 2) ca. 0.5 h; Yield given. Multistep reaction. Yields of byproduct given;
With sodium hydroxide; mercury(II) diacetate In tetrahydrofuran; water Product distribution; 1) 30 min, 2) ca. 0.5 h;
((3-methoxypropoxy)methyl)benzene
96516-91-5

((3-methoxypropoxy)methyl)benzene

A

methoxypropanol
1589-49-7

methoxypropanol

B

(diethoxymethyl)benzene
774-48-1

(diethoxymethyl)benzene

C

[Ethoxy-(3-methoxy-propoxy)-methyl]-benzene
100189-72-8

[Ethoxy-(3-methoxy-propoxy)-methyl]-benzene

D

benzaldehyde
100-52-7

benzaldehyde

Conditions
ConditionsYield
With hydrogen; palladium hydroxide - carbon In ethanol Heating;
trimethylene glycol monosodium salt
37480-93-6, 54481-30-0, 59571-05-0

trimethylene glycol monosodium salt

methyl iodide
74-88-4

methyl iodide

methoxypropanol
1589-49-7

methoxypropanol

Conditions
ConditionsYield
In various solvent(s)
1,3-dioxane
505-22-6

1,3-dioxane

A

methoxypropanol
1589-49-7

methoxypropanol

B

3-methoxy-1-propanal
2806-84-0

3-methoxy-1-propanal

C

alkoxyalkyl substd. 1,3-dioxanes, H2, CO, CO2

alkoxyalkyl substd. 1,3-dioxanes, H2, CO, CO2

Conditions
ConditionsYield
Mechanism; Product distribution; Quantum yield; Irradiation; 185 nm vacuum-ultraviolet photolysis;
methyl iodide
74-88-4

methyl iodide

monosodium compound of trimethylene glycol

monosodium compound of trimethylene glycol

methoxypropanol
1589-49-7

methoxypropanol

1-methoxy-3-vinyloxy-propane
3046-32-0

1-methoxy-3-vinyloxy-propane

ethylene glycol
107-21-1

ethylene glycol

A

methoxypropanol
1589-49-7

methoxypropanol

B

acetaldehyde ethylenacetal

acetaldehyde ethylenacetal

Conditions
ConditionsYield
With hydrogenchloride
hydrogenchloride
7647-01-0

hydrogenchloride

1-methoxy-3-vinyloxy-propane
3046-32-0

1-methoxy-3-vinyloxy-propane

ethylene glycol
107-21-1

ethylene glycol

A

methoxypropanol
1589-49-7

methoxypropanol

B

acetaldehyde ethylenacetal

acetaldehyde ethylenacetal

methanol
67-56-1

methanol

propene
187737-37-7

propene

A

propylene glycol
57-55-6

propylene glycol

B

methoxypropanol
1589-49-7

methoxypropanol

C

methyloxirane
75-56-9, 16033-71-9

methyloxirane

Conditions
ConditionsYield
With dihydrogen peroxide; Nb-hexagonal mesoporous silica In water at 49.85℃; under 6000.48 Torr; for 4h; Product distribution; Further Variations:; Catalysts; Reagents;
1,1,3-trimethoxypropane
14315-97-0

1,1,3-trimethoxypropane

3-methoxy-1-propanal
2806-84-0

3-methoxy-1-propanal

methoxypropanol
1589-49-7

methoxypropanol

Conditions
ConditionsYield
With hydrogen; nickel at 80℃; under 37503.8 Torr; for 3 - 4h;
1,1,3-trimethoxypropane
14315-97-0

1,1,3-trimethoxypropane

A

methoxypropanol
1589-49-7

methoxypropanol

B

propionic acid-(3-methoxy-propyl ester)

propionic acid-(3-methoxy-propyl ester)

C

propionic acid
802294-64-0

propionic acid

Conditions
ConditionsYield
With hydrogen; Ru/C at 80℃; under 37503.8 Torr; for 3h;
1,1,3-trimethoxypropane
14315-97-0

1,1,3-trimethoxypropane

methoxypropanol
1589-49-7

methoxypropanol

Conditions
ConditionsYield
With hydrogen; nickel at 80℃; under 37503.8 Torr; for 3h;
In trifluoroacetic acid
methanol
67-56-1

methanol

allyl alcohol
107-18-6

allyl alcohol

A

methoxypropanol
1589-49-7

methoxypropanol

B

3-allyloxy-1-propanol
6180-67-2

3-allyloxy-1-propanol

Conditions
ConditionsYield
activated carbon-supported lantahanium oxide at 200℃; for 6h; Product distribution / selectivity;
magnesium oxide In water at 200℃; for 6h; Product distribution / selectivity;
magnesium oxide at 200℃; for 6h; Product distribution / selectivity;
3-methoxy-1-propanal
2806-84-0

3-methoxy-1-propanal

pyrographite
7440-44-0

pyrographite

ruthenium
7440-18-8

ruthenium

methoxypropanol
1589-49-7

methoxypropanol

methylene chloride
74-87-3

methylene chloride

C3H7O2(1-)

C3H7O2(1-)

methoxypropanol
1589-49-7

methoxypropanol

Conditions
ConditionsYield
at 76.84℃; under 3E-07 - 5E-06 Torr; Kinetics;
methoxypropanol
1589-49-7

methoxypropanol

methyl 6-(2,6-difluoro-4-hydroxyphenyl)-5-fluoropyridine-2-carboxylate
1355011-30-1

methyl 6-(2,6-difluoro-4-hydroxyphenyl)-5-fluoropyridine-2-carboxylate

methyl 6-(2,6-difluoro-4-(3-methoxypropoxy)phenyl)-5-fluoropicolinate
1395283-97-2

methyl 6-(2,6-difluoro-4-(3-methoxypropoxy)phenyl)-5-fluoropicolinate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃;100%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃;100%
methoxypropanol
1589-49-7

methoxypropanol

trimethyleneglycol
504-63-2

trimethyleneglycol

Conditions
ConditionsYield
With Strong acid resin at 100℃; for 1h; Temperature; Reagent/catalyst;99.2%
With phosphoric acid; hydrogen iodide; sodium iodide at 105℃; Reagent/catalyst; Autoclave;88%
With water; sulfuric acid at 190℃; for 10h; Product distribution / selectivity;
methoxypropanol
1589-49-7

methoxypropanol

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

3-Methoxy-1-propanol methanesulphonate
127686-58-2

3-Methoxy-1-propanol methanesulphonate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 18h;97%
With triethylamine In dichloromethane at 0 - 20℃; for 18h;97%
With triethylamine In dichloromethane at 0 - 20℃; for 2h;96%
4-chloro-2,3-dimethylpyridine-N-oxide
59886-90-7

4-chloro-2,3-dimethylpyridine-N-oxide

methoxypropanol
1589-49-7

methoxypropanol

2,3-dimethyl-4-(3-methoxypropoxy)pyridine nitroxide
117977-18-1

2,3-dimethyl-4-(3-methoxypropoxy)pyridine nitroxide

Conditions
ConditionsYield
Stage #1: methoxypropanol With sodium hydroxide In dimethyl sulfoxide at 20 - 60℃;
Stage #2: 4-chloro-2,3-dimethylpyridine-N-oxide In dimethyl sulfoxide at 75℃; for 5h;
95%
With methyl tributylammonium chloride; sodium hydroxide In water; toluene at 100℃; for 8h; Large scale reaction;94%
With sodium hydroxide; N-methyl-tri-n-butyl-ammonium bromide In water at 100℃; for 8h;84.6%
methoxypropanol
1589-49-7

methoxypropanol

(6S,9S)-N-benzyl-6-(4-hydroxybenzyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)octahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide
1198780-43-6

(6S,9S)-N-benzyl-6-(4-hydroxybenzyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)octahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide

(6S,9S)-N-benzyl-6-(4-(3-methoxypropoxy)benzyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)octahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide
1394313-73-5

(6S,9S)-N-benzyl-6-(4-(3-methoxypropoxy)benzyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)octahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide

Conditions
ConditionsYield
With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine In tetrahydrofuran at 20℃;95%
methoxypropanol
1589-49-7

methoxypropanol

cyclohexene-1-carboxylic acid
636-82-8

cyclohexene-1-carboxylic acid

3-methoxypropyl cyclohex-1-enecarboxylate
1449522-67-1

3-methoxypropyl cyclohex-1-enecarboxylate

Conditions
ConditionsYield
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 0 - 20℃; Inert atmosphere;95%
norborn-2-ene
498-66-8

norborn-2-ene

methoxypropanol
1589-49-7

methoxypropanol

exo-2-(3-methoxypropoxy)bicyclo[2.2.1]heptane

exo-2-(3-methoxypropoxy)bicyclo[2.2.1]heptane

Conditions
ConditionsYield
With (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate; triphenylphosphine In Tridecane; toluene at 85℃; for 24h;92%
4-nitro-phenol
100-02-7

4-nitro-phenol

methoxypropanol
1589-49-7

methoxypropanol

1-(3-methoxypropoxy)-4-nitrobenzene
102015-09-8

1-(3-methoxypropoxy)-4-nitrobenzene

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 2h;91%
With di-isopropyl azodicarboxylate; triphenylphosphine at 0 - 20℃; for 2.5h;89%
methoxypropanol
1589-49-7

methoxypropanol

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

3-methoxypropyl p-toluenesulfonate
54646-36-5

3-methoxypropyl p-toluenesulfonate

Conditions
ConditionsYield
With pyridine at 0 - 10℃; for 3h;89%
84%
With pyridine; dmap In dichloromethane at 20℃; for 72h;76%
5-chloro-1,3-benzodioxole
7228-38-8

5-chloro-1,3-benzodioxole

methoxypropanol
1589-49-7

methoxypropanol

5-(3-methoxypropoxy)benzo[d][1,3]dioxole

5-(3-methoxypropoxy)benzo[d][1,3]dioxole

Conditions
ConditionsYield
With C12H10N(1-)*CH3O3S(1-)*Pd(2+)*C39H57O2P; sodium t-butanolate In 1,4-dioxane at 60℃; for 18h; Reagent/catalyst; Sealed tube; Schlenk technique; Inert atmosphere;87%
2-chloro-4-picoline
3678-62-4

2-chloro-4-picoline

methoxypropanol
1589-49-7

methoxypropanol

2-(3-methoxypropoxy)-4-methylpyridine

2-(3-methoxypropoxy)-4-methylpyridine

Conditions
ConditionsYield
With C12H10N(1-)*Pd(2+)*CH3O3S(1-)*C31H49O2P; sodium t-butanolate In 1,4-dioxane at 20℃; for 6h; Sealed tube; Schlenk technique; Inert atmosphere;86%
methoxypropanol
1589-49-7

methoxypropanol

3-methoxy-1-propanal
2806-84-0

3-methoxy-1-propanal

Conditions
ConditionsYield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In ethyl acetate Reflux;85%
With pyridinium chlorochromate In dichloromethane at 20℃; for 12h; Inert atmosphere;65%
With PyCrO3*HCl In dichloromethane at 20℃; for 2h;36.8%
{Cu(2,2,6,6-tetramethylheptane-3,5-dionate)(isopropoxy)}2

{Cu(2,2,6,6-tetramethylheptane-3,5-dionate)(isopropoxy)}2

methoxypropanol
1589-49-7

methoxypropanol

{Cu(2,2,6,6-tetramethylheptane-3,5-dionate)(OCH2CH2CH2OCH3)}2

{Cu(2,2,6,6-tetramethylheptane-3,5-dionate)(OCH2CH2CH2OCH3)}2

Conditions
ConditionsYield
In tetrahydrofuran (dry N2), dry solvents; addn. of Cu-compd. to mixt. of 3-methoxypropanol and THF, react. time 2 h; evapn. to dryness, recrystn. (hexane) at -30°C; elem. anal.;85%
methoxypropanol
1589-49-7

methoxypropanol

6-(6-fluoro-1H-indol-1-yl)-2-(3-(5-hydroxypyrimidin-2-yl)benzyl)pyridazin-3(2H)-one

6-(6-fluoro-1H-indol-1-yl)-2-(3-(5-hydroxypyrimidin-2-yl)benzyl)pyridazin-3(2H)-one

6-(6-fluoro-1H-indol-1-yl)-2-(3-(5-(3-methoxypropoxy)pyrimidin-2-yl)benzyl)pyridazin-3(2H)-one

6-(6-fluoro-1H-indol-1-yl)-2-(3-(5-(3-methoxypropoxy)pyrimidin-2-yl)benzyl)pyridazin-3(2H)-one

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 12h; Mitsunobu Displacement;84%
7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid chloride
929904-81-4

7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid chloride

methoxypropanol
1589-49-7

methoxypropanol

3-methoxypropyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

3-methoxypropyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 4h;84%
methoxypropanol
1589-49-7

methoxypropanol

7-bromo-5-chloro-3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[4,3-b]pyridine

7-bromo-5-chloro-3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[4,3-b]pyridine

5-chloro-3-iodo-7-(3-methoxypropoxy)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[4,3-b]pyridine

5-chloro-3-iodo-7-(3-methoxypropoxy)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[4,3-b]pyridine

Conditions
ConditionsYield
Stage #1: methoxypropanol With sodium hydride In 1,4-dioxane; mineral oil for 0.5h;
Stage #2: 7-bromo-5-chloro-3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[4,3-b]pyridine In 1,4-dioxane; mineral oil at 100℃; for 2h;
81%
methoxypropanol
1589-49-7

methoxypropanol

2-chloro-5-methylphenol
615-74-7

2-chloro-5-methylphenol

1-chloro-2-(3-methoxy-propoxy)-4-methyl-benzene
1000045-32-8

1-chloro-2-(3-methoxy-propoxy)-4-methyl-benzene

Conditions
ConditionsYield
With triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine In dichloromethane at 20℃; for 16h;80%
With triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine In dichloromethane at 20℃; for 16h; Mitsunobu reaction;80%
3-chlorothiophene
17249-80-8

3-chlorothiophene

methoxypropanol
1589-49-7

methoxypropanol

C8H12O2S

C8H12O2S

Conditions
ConditionsYield
With N1,N2-bis(naphthalen-1-ylmethyl)oxalamide; potassium tert-butylate; copper diacetate In 1,4-dioxane at 100℃; for 24h; Schlenk technique; Inert atmosphere; Molecular sieve;78%
methoxypropanol
1589-49-7

methoxypropanol

2-bromo-6-iodo-3-methoxypyridine
321535-37-9

2-bromo-6-iodo-3-methoxypyridine

6-iodo-3-methoxy-2-(3-methoxypropoxy)pyridine

6-iodo-3-methoxy-2-(3-methoxypropoxy)pyridine

Conditions
ConditionsYield
Stage #1: methoxypropanol With sodium hydride In N,N-dimethyl-formamide for 0.666667h;
Stage #2: 2-bromo-6-iodo-3-methoxypyridine In N,N-dimethyl-formamide at 100℃; for 3h;
77%
methoxypropanol
1589-49-7

methoxypropanol

C66H4O3
273214-08-7

C66H4O3

C70H14O5

C70H14O5

Conditions
ConditionsYield
In toluene at 60℃; for 5h; Esterification;76%
methoxypropanol
1589-49-7

methoxypropanol

methyl 4-bromo-3-hydroxybenzoate
106291-80-9

methyl 4-bromo-3-hydroxybenzoate

4-bromo-3-(3-methoxy-propoxy)-benzoic acid methyl ester
895240-78-5

4-bromo-3-(3-methoxy-propoxy)-benzoic acid methyl ester

Conditions
ConditionsYield
With triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine In dichloromethane at 20℃;75%
With triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine In dichloromethane at 20℃; Mitsunobu reaction;75%
With triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine In dichloromethane at 20℃;
methoxypropanol
1589-49-7

methoxypropanol

ethyl 1-(6-chloropyrimidin-4-yl)cyclopropane-1-carboxylate

ethyl 1-(6-chloropyrimidin-4-yl)cyclopropane-1-carboxylate

ethyl 1-(6-(3-methoxypropoxy)pyrimidin-4-yl)cyclopropane-1-carboxylate

ethyl 1-(6-(3-methoxypropoxy)pyrimidin-4-yl)cyclopropane-1-carboxylate

Conditions
ConditionsYield
With sodium hydride In ethanol for 5h; Reflux;74.8%
methoxypropanol
1589-49-7

methoxypropanol

pivaloyl chloride
3282-30-2

pivaloyl chloride

3-methoxypropyl pivalate

3-methoxypropyl pivalate

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃;74%
methoxypropanol
1589-49-7

methoxypropanol

1-Chloro-3-methoxypropane
36215-07-3

1-Chloro-3-methoxypropane

Conditions
ConditionsYield
With pyridine; thionyl chloride at 10 - 65℃; for 3h;72%
With pyridine; thionyl chloride at 10 - 65℃;72%
With pyridine; thionyl chloride at 10 - 70℃; for 8h; Inert atmosphere;71%
methoxypropanol
1589-49-7

methoxypropanol

tetrakis(chlorodimethylsilyl)silane
17082-82-5

tetrakis(chlorodimethylsilyl)silane

tetrakis(dimethyl(3-methoxypropoxy)silyl)silane
1293370-37-2

tetrakis(dimethyl(3-methoxypropoxy)silyl)silane

Conditions
ConditionsYield
With triethylamine In hexane at 20℃; Inert atmosphere; Cooling with ice;71%
methoxypropanol
1589-49-7

methoxypropanol

benzylamine
100-46-9

benzylamine

N-benzylpropanamide
10264-12-7

N-benzylpropanamide

Conditions
ConditionsYield
With dichloro(benzene)ruthenium(II) dimer; N,N-diisopropylimidazolium bromide; sodium hydride In toluene; acetonitrile for 24h; Inert atmosphere; Reflux;71%
methoxypropanol
1589-49-7

methoxypropanol

rac-Pro-OH
609-36-9

rac-Pro-OH

1-(3-methoxypropyl)pyrrolidine

1-(3-methoxypropyl)pyrrolidine

Conditions
ConditionsYield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium hydrogencarbonate In toluene at 110℃; for 72h; Inert atmosphere;69%
methoxypropanol
1589-49-7

methoxypropanol

4-amino-2-chloro-6-(trifluoromethyl)pyridine
34486-22-1

4-amino-2-chloro-6-(trifluoromethyl)pyridine

2-(3-methoxypropoxy)-6-(trifluoromethyl)pyridin-4-amine

2-(3-methoxypropoxy)-6-(trifluoromethyl)pyridin-4-amine

Conditions
ConditionsYield
Stage #1: methoxypropanol With sodium hydride In 1,4-dioxane at 20℃; for 1h;
Stage #2: 2-chloro-6-(trifluoromethyl)pyridin-4-amine In 1,4-dioxane at 110℃;
68%

1589-49-7Relevant articles and documents

Searching for the Ionized Alkene/Alkanol Complexes +./HOCH3> and +./HOCH2CH3>

Cao, J. R.,George, M.,Holmes, John L.

, p. 481 - 485 (1991)

Experiments on a variety of isomeric +. and +. ions have failed to produce direct evidence for the involvement of the complex ions +./HOCH3> and +./HOC2H5>.For the isomers studied, the rearrangements prior to their dissociation of lowest energy requirement (loss of H2O and C2H5., respectively) are proposed to involve distonic and ylid ions.

-

Leggetter,B.E. et al.

, p. 2113 - 2118 (1964)

-

A HPPO by-product recycling synthetic 1, 3 - propanediol (by machine translation)

-

Paragraph 0036-0041, (2019/07/04)

The invention belongs to the technical field of organic chemical industry, relates to a HPPO by-product recycling synthetic 1, 3 - propanediol, more specifically, relates to a propylene HPPO process with methanol the reaction product of propylene glycol monomethyl ether as the raw material, and sequentially passes through the dewatering, borohydrite oxidation, hydrolysis of the three-step reaction synthesizes the high value added 1, 3 - propylene glycol, 1, 3 - propylene glycol total yield of 80% or more, purity 99.5% or more, the invention has the simple process route, rationalization of resources use, 1, 3 - propylene glycol yield and purity and the like. (by machine translation)

CONTROLLED RELEASE PREPARATION

-

Paragraph 0529; 0530, (2016/06/06)

A controlled release preparation wherein the release of active ingredient is controlled, which releases an active ingredient for an extended period of time by staying or slowly migrating in the gastrointestinal tract, is provided by means such as capsulating a tablet, granule or fine granule wherein the release of active ingredient is controlled and a gel-forming polymer. Said tablet, granule or fine granule has a release-controlled coating-layer formed on a core particle containing an active ingredient.

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