1589-49-7

Basic information

• Product Name: 3-Methoxy-1-propanol
• Synonyms: 3-METHOXY-1-PROPANOL;3-METHOXYPROPAN-1-OL;3-METHOXYPROPANE-1-OL;3-METHOXYPROPANOL;3-METHOXYPROPANOL-1;1,3-PROPANEDIOL MONOMETHYL ETHER;MPOL;1-Propanol, 3-methoxy-
• CAS NO: 1589-49-7
• Molecular Formula: C₄H₁₀O₂
• Molecular Weight: 90.12
• EINECS: 433-230-9
• Product Categories: PHARMACEUTICAL INTERMEDIATES;Alcohols;C2 to C6;Oxygen Compounds;Rabeprazole
• Mol File: 1589-49-7.mol
• Article Data: 36

Chemical Properties

• Melting Point: -84.2°C (estimate)
• Boiling Point: 150-152 °C
• Flash Point: 38°C
• Appearance: Clear colorless/Liquid
• Density: 0.942 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.952mmHg at 25°C
• Refractive Index: n20/D 1.413
• Storage Temp.: Store below +30°C.
• PKA: 14.89±0.10(Predicted)
• Water Solubility: Completely miscible in water
• BRN: 1731204
• CAS DataBase Reference: 3-Methoxy-1-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methoxy-1-propanol(1589-49-7)
• EPA Substance Registry System: 3-Methoxy-1-propanol(1589-49-7)

Safety Data

• Hazard Codes: Xi,F
• Statements: 10-38-36/38
• Safety Statements: 16-37-26
• RIDADR: UN 1987 3/PG 3
• WGK Germany: 1
• RTECS: UB7650000
• HazardClass: FLAMMABLE
• PackingGroup: III
• Hazardous Substances Data: 1589-49-7(Hazardous Substances Data)

Usage

Description

3-Methoxy-1-propanol, also known as 1-methoxy-3-propanol, is a primary alcohol with the molecular formula C4H10O2. It is a colorless liquid that has been studied for its reactions with phenyl isocyanate in the presence of metal catalysts. The selective synthesis of 3-methoxy-1-propanol from methanol and allyl alcohol using metal oxides and zeolites as catalysts in the liquid phase has also been investigated.

Uses

Used in Chemical Synthesis:
3-Methoxy-1-propanol is used as a reactant in the chemical synthesis of various compounds. Its reactivity with phenyl isocyanate in the presence of metal catalysts makes it a valuable intermediate for the production of a range of chemical products.
Used in Solvent Applications:
Due to its solubility properties, 3-Methoxy-1-propanol is used as a solvent in various industrial processes. It can dissolve a wide range of substances, making it useful in the manufacturing of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Fuel Additives:
3-Methoxy-1-propanol can be used as a component in the formulation of fuel additives. Its ability to mix with various substances and improve the overall performance of the fuel makes it a valuable addition to the fuel industry.
Used in Cosmetics and Personal Care:
In the cosmetics and personal care industry, 3-Methoxy-1-propanol is used as a solvent and a component in the formulation of various products, such as fragrances, lotions, and creams. Its compatibility with a wide range of ingredients and its ability to improve the texture and consistency of the final product make it a popular choice in this sector.
Used in Paints and Coatings:
3-Methoxy-1-propanol is also utilized in the paint and coatings industry as a solvent. It helps to improve the flow and leveling properties of the paint, ensuring a smooth and even application.
Used in Adhesives:
In the adhesives industry, 3-Methoxy-1-propanol is used as a solvent and a component in the formulation of various types of adhesives. Its ability to dissolve and mix with other components makes it an essential part of the manufacturing process.
Used in Lubricants:
3-Methoxy-1-propanol can be used in the formulation of lubricants, where it helps to improve the viscosity and flow properties of the final product, enhancing its performance in various applications.
Used in Plasticizers:
In the plastics industry, 3-Methoxy-1-propanol is used as a plasticizer, which is a substance added to plastics to increase their flexibility and workability. Its compatibility with various types of plastics makes it a valuable addition to the industry.
Used in Inks and Dyes:
3-Methoxy-1-propanol is also used in the ink and dye industry as a solvent and a component in the formulation of various types of inks and dyes. Its ability to dissolve a wide range of pigments and dyes makes it an essential part of the manufacturing process.

InChI:InChI=1/C4H10O2/c1-6-4-2-3-5/h5H,2-4H2,1H3

Synthetic route

methylallylether (627-40-7) → methoxypropanol (1589-49-7)

Conditions	Yield
Stage #1: methylallylether With diborane In dimethyl sulfoxide Inert atmosphere; Stage #2: With dihydrogen peroxide; sodium hydroxide In dimethyl sulfoxide Reagent/catalyst; Solvent;	91.2%

methyl iodide (74-88-4) + trimethyleneglycol (504-63-2) → methoxypropanol (1589-49-7)

Conditions	Yield
With mercury(II) oxide In dichloromethane at 20℃; for 28h;	72%
With sodium In octane
With potassium carbonate Multistep reaction;

1,3-dioxane (505-22-6) → methoxypropanol (1589-49-7)

Conditions	Yield
With diisobutylaluminium hydride In benzene for 1h; Heating; further reagents: triethylaluminum, triisobutylaluminum with Pd(acac)2;	65%
With lithium aluminium tetrahydride; boron trichloride 1.) CH2Cl2, 0.2 h, 2.) Et2O, 30 min; Yield given. Multistep reaction;

methyl 3-methoxypropionate (3852-09-3) → methoxypropanol (1589-49-7)

Conditions	Yield
Stage #1: methyl 3-methoxypropionate With lithium aluminium tetrahydride In diethyl ether for 4.5h; Inert atmosphere; Stage #2: With water; sodium hydroxide In diethyl ether at 0 - 20℃;	60%
Stage #1: methyl 3-methoxypropionate With lithium aluminium tetrahydride In diethyl ether for 4.5h; Stage #2: With sodium hydroxide; water In diethyl ether at 0℃;	60%
With hydrogen In methanol at 170℃; under 150015 Torr;	51%

methanol (67-56-1) + 1-bromo-3-propanol (627-18-9) → methoxypropanol (1589-49-7)

Conditions	Yield
With sodium In methanol 1.) 20 deg. C, 1 h, 2.) reflux, 1 h;	20%

trimethylene oxide (503-30-0) + methanol (67-56-1) → methoxypropanol (1589-49-7)

Conditions	Yield
With sulfuric acid

trimethylene oxide (503-30-0) + sodium methylate (124-41-4) → methoxypropanol (1589-49-7)

Conditions	Yield
With methanol at 175℃;

3-methoxy-1-propanal (2806-84-0) → methoxypropanol (1589-49-7)

Conditions	Yield
With methanol; pumice stone; nickel at 45 - 100℃; Hydrogenation;
With sodium metaborate In water
With hydrogen; nickel at 80℃; under 37503.8 Torr; for 3h;
With hydrogen; Ru/C under 37503.8 Torr; for 3h;

methanol (67-56-1) + acrolein (107-02-8) → methoxypropanol (1589-49-7)

Conditions	Yield
With sodium hydroxide; hydroquinone beim Ansaeuern mit Essigsaeure und anschliessenden Hydrieren an Raney-Nickel bei 93grad/70 at;

3-Methoxypropionitrile (110-67-8) → methoxypropanol (1589-49-7)

Conditions	Yield
(i) EtOH, H2SO4, (ii) LiAlH4; Multistep reaction;

sodium methylate (124-41-4) + 1-chloro-3-hydroxypropane (627-30-5) → methoxypropanol (1589-49-7)

Conditions	Yield
In methanol

tetrahydrofuran (109-99-9) → trimethylene oxide (503-30-0) + methoxypropanol (1589-49-7)

Conditions	Yield
With methane; water; oxygen Irradiation;

1,3-dioxane (505-22-6) → methoxypropanol (1589-49-7) + trimethyleneglycol (504-63-2)

Conditions	Yield
With lithium aluminium tetrahydride; boron tribromide 1.) CH2Cl2, 0 deg C, 0.03 h, 2.) Et2O, 30 min; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

3-bromopropanol methyl ether (36865-41-5) → methoxypropanol (1589-49-7)

Conditions	Yield
With water; triethylamine In ethanol at 124.8℃; Kinetics; further temperatures, further solvent, activation enthalpy and entropy;

methylallylether (627-40-7) → propan-1-ol (71-23-8) + 1-methoxy-2-propanol (107-98-2) + methoxypropanol (1589-49-7)

Conditions	Yield
With sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide Product distribution; 1) THF, 25 deg C, 2 h;	A 1.5 % Chromat. B n/a C 94 % Chromat.

methylallylether (627-40-7) → 1-methoxy-2-propanol (107-98-2) + methoxypropanol (1589-49-7)

Conditions	Yield
With sodium hydroxide; sodium tetrahydroborate; mercury(II) diacetate 1) water, THF, 30 min, 2) ca. 0.5 h; Yield given. Multistep reaction. Yields of byproduct given;
With sodium hydroxide; mercury(II) diacetate In tetrahydrofuran; water Product distribution; 1) 30 min, 2) ca. 0.5 h;

((3-methoxypropoxy)methyl)benzene (96516-91-5) → methoxypropanol (1589-49-7) + (diethoxymethyl)benzene (774-48-1) + [Ethoxy-(3-methoxy-propoxy)-methyl]-benzene (100189-72-8) + benzaldehyde (100-52-7)

Conditions	Yield
With hydrogen; palladium hydroxide - carbon In ethanol Heating;

trimethylene glycol monosodium salt (37480-93-6, 54481-30-0, 59571-05-0) + methyl iodide (74-88-4) → methoxypropanol (1589-49-7)

Conditions	Yield
In various solvent(s)

1,3-dioxane (505-22-6) → methoxypropanol (1589-49-7) + 3-methoxy-1-propanal (2806-84-0) + alkoxyalkyl substd. 1,3-dioxanes, H2, CO, CO2

Conditions	Yield
Mechanism; Product distribution; Quantum yield; Irradiation; 185 nm vacuum-ultraviolet photolysis;

methyl iodide (74-88-4) + monosodium compound of trimethylene glycol → methoxypropanol (1589-49-7)

1-methoxy-3-vinyloxy-propane (3046-32-0) + ethylene glycol (107-21-1) → methoxypropanol (1589-49-7) + acetaldehyde ethylenacetal

Conditions	Yield
With hydrogenchloride

hydrogenchloride (7647-01-0) + 1-methoxy-3-vinyloxy-propane (3046-32-0) + ethylene glycol (107-21-1) → methoxypropanol (1589-49-7) + acetaldehyde ethylenacetal

methanol (67-56-1) + propene (187737-37-7) → propylene glycol (57-55-6) + methoxypropanol (1589-49-7) + methyloxirane (75-56-9, 16033-71-9)

Conditions	Yield
With dihydrogen peroxide; Nb-hexagonal mesoporous silica In water at 49.85℃; under 6000.48 Torr; for 4h; Product distribution; Further Variations:; Catalysts; Reagents;

1,1,3-trimethoxypropane (14315-97-0) + 3-methoxy-1-propanal (2806-84-0) → methoxypropanol (1589-49-7)

Conditions	Yield
With hydrogen; nickel at 80℃; under 37503.8 Torr; for 3 - 4h;

1,1,3-trimethoxypropane (14315-97-0) → methoxypropanol (1589-49-7) + propionic acid-(3-methoxy-propyl ester) + propionic acid (802294-64-0)

Conditions	Yield
With hydrogen; Ru/C at 80℃; under 37503.8 Torr; for 3h;

1,1,3-trimethoxypropane (14315-97-0) → methoxypropanol (1589-49-7)

Conditions	Yield
With hydrogen; nickel at 80℃; under 37503.8 Torr; for 3h;
In trifluoroacetic acid

methanol (67-56-1) + allyl alcohol (107-18-6) → methoxypropanol (1589-49-7) + 3-allyloxy-1-propanol (6180-67-2)

Conditions	Yield
activated carbon-supported lantahanium oxide at 200℃; for 6h; Product distribution / selectivity;
magnesium oxide In water at 200℃; for 6h; Product distribution / selectivity;
magnesium oxide at 200℃; for 6h; Product distribution / selectivity;

3-methoxy-1-propanal (2806-84-0) + pyrographite (7440-44-0) + ruthenium (7440-18-8) → methoxypropanol (1589-49-7)

methylene chloride (74-87-3) + C3H7O2(1-) → methoxypropanol (1589-49-7)

Conditions	Yield
at 76.84℃; under 3E-07 - 5E-06 Torr; Kinetics;

methoxypropanol (1589-49-7) + methyl 6-(2,6-difluoro-4-hydroxyphenyl)-5-fluoropyridine-2-carboxylate (1355011-30-1) → methyl 6-(2,6-difluoro-4-(3-methoxypropoxy)phenyl)-5-fluoropicolinate (1395283-97-2)

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃;	100%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃;	100%

methoxypropanol (1589-49-7) → trimethyleneglycol (504-63-2)

Conditions	Yield
With Strong acid resin at 100℃; for 1h; Temperature; Reagent/catalyst;	99.2%
With phosphoric acid; hydrogen iodide; sodium iodide at 105℃; Reagent/catalyst; Autoclave;	88%
With water; sulfuric acid at 190℃; for 10h; Product distribution / selectivity;

methoxypropanol (1589-49-7) + methanesulfonyl chloride (124-63-0) → 3-Methoxy-1-propanol methanesulphonate (127686-58-2)

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 18h;	97%
With triethylamine In dichloromethane at 0 - 20℃; for 18h;	97%
With triethylamine In dichloromethane at 0 - 20℃; for 2h;	96%

4-chloro-2,3-dimethylpyridine-N-oxide (59886-90-7) + methoxypropanol (1589-49-7) → 2,3-dimethyl-4-(3-methoxypropoxy)pyridine nitroxide (117977-18-1)

Conditions	Yield
Stage #1: methoxypropanol With sodium hydroxide In dimethyl sulfoxide at 20 - 60℃; Stage #2: 4-chloro-2,3-dimethylpyridine-N-oxide In dimethyl sulfoxide at 75℃; for 5h;	95%
With methyl tributylammonium chloride; sodium hydroxide In water; toluene at 100℃; for 8h; Large scale reaction;	94%
With sodium hydroxide; N-methyl-tri-n-butyl-ammonium bromide In water at 100℃; for 8h;	84.6%

methoxypropanol (1589-49-7) + (6S,9S)-N-benzyl-6-(4-hydroxybenzyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)octahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide (1198780-43-6) → (6S,9S)-N-benzyl-6-(4-(3-methoxypropoxy)benzyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)octahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide (1394313-73-5)

Conditions	Yield
With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine In tetrahydrofuran at 20℃;	95%

methoxypropanol (1589-49-7) + cyclohexene-1-carboxylic acid (636-82-8) → 3-methoxypropyl cyclohex-1-enecarboxylate (1449522-67-1)

Conditions	Yield
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 0 - 20℃; Inert atmosphere;	95%

norborn-2-ene (498-66-8) + methoxypropanol (1589-49-7) → exo-2-(3-methoxypropoxy)bicyclo[2.2.1]heptane

Conditions	Yield
With (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate; triphenylphosphine In Tridecane; toluene at 85℃; for 24h;	92%

4-nitro-phenol (100-02-7) + methoxypropanol (1589-49-7) → 1-(3-methoxypropoxy)-4-nitrobenzene (102015-09-8)

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 2h;	91%
With di-isopropyl azodicarboxylate; triphenylphosphine at 0 - 20℃; for 2.5h;	89%

methoxypropanol (1589-49-7) + p-toluenesulfonyl chloride (98-59-9) → 3-methoxypropyl p-toluenesulfonate (54646-36-5)

Conditions	Yield
With pyridine at 0 - 10℃; for 3h;	89%
	84%
With pyridine; dmap In dichloromethane at 20℃; for 72h;	76%

5-chloro-1,3-benzodioxole (7228-38-8) + methoxypropanol (1589-49-7) → 5-(3-methoxypropoxy)benzo[d][1,3]dioxole

Conditions	Yield
With C12H10N(1-)*CH3O3S(1-)*Pd(2+)*C39H57O2P; sodium t-butanolate In 1,4-dioxane at 60℃; for 18h; Reagent/catalyst; Sealed tube; Schlenk technique; Inert atmosphere;	87%

2-chloro-4-picoline (3678-62-4) + methoxypropanol (1589-49-7) → 2-(3-methoxypropoxy)-4-methylpyridine

Conditions	Yield
With C12H10N(1-)*Pd(2+)*CH3O3S(1-)*C31H49O2P; sodium t-butanolate In 1,4-dioxane at 20℃; for 6h; Sealed tube; Schlenk technique; Inert atmosphere;	86%

methoxypropanol (1589-49-7) → 3-methoxy-1-propanal (2806-84-0)

Conditions	Yield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In ethyl acetate Reflux;	85%
With pyridinium chlorochromate In dichloromethane at 20℃; for 12h; Inert atmosphere;	65%
With PyCrO3*HCl In dichloromethane at 20℃; for 2h;	36.8%

{Cu(2,2,6,6-tetramethylheptane-3,5-dionate)(isopropoxy)}2 + methoxypropanol (1589-49-7) → {Cu(2,2,6,6-tetramethylheptane-3,5-dionate)(OCH2CH2CH2OCH3)}2

Conditions	Yield
In tetrahydrofuran (dry N2), dry solvents; addn. of Cu-compd. to mixt. of 3-methoxypropanol and THF, react. time 2 h; evapn. to dryness, recrystn. (hexane) at -30°C; elem. anal.;	85%

methoxypropanol (1589-49-7) + 6-(6-fluoro-1H-indol-1-yl)-2-(3-(5-hydroxypyrimidin-2-yl)benzyl)pyridazin-3(2H)-one → 6-(6-fluoro-1H-indol-1-yl)-2-(3-(5-(3-methoxypropoxy)pyrimidin-2-yl)benzyl)pyridazin-3(2H)-one

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 12h; Mitsunobu Displacement;	84%

7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid chloride (929904-81-4) + methoxypropanol (1589-49-7) → 3-methoxypropyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 4h;	84%

methoxypropanol (1589-49-7) + 7-bromo-5-chloro-3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[4,3-b]pyridine → 5-chloro-3-iodo-7-(3-methoxypropoxy)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[4,3-b]pyridine

Conditions	Yield
Stage #1: methoxypropanol With sodium hydride In 1,4-dioxane; mineral oil for 0.5h; Stage #2: 7-bromo-5-chloro-3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[4,3-b]pyridine In 1,4-dioxane; mineral oil at 100℃; for 2h;	81%

methoxypropanol (1589-49-7) + 2-chloro-5-methylphenol (615-74-7) → 1-chloro-2-(3-methoxy-propoxy)-4-methyl-benzene (1000045-32-8)

Conditions	Yield
With triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine In dichloromethane at 20℃; for 16h;	80%
With triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine In dichloromethane at 20℃; for 16h; Mitsunobu reaction;	80%

3-chlorothiophene (17249-80-8) + methoxypropanol (1589-49-7) → C8H12O2S

Conditions	Yield
With N1,N2-bis(naphthalen-1-ylmethyl)oxalamide; potassium tert-butylate; copper diacetate In 1,4-dioxane at 100℃; for 24h; Schlenk technique; Inert atmosphere; Molecular sieve;	78%

methoxypropanol (1589-49-7) + 2-bromo-6-iodo-3-methoxypyridine (321535-37-9) → 6-iodo-3-methoxy-2-(3-methoxypropoxy)pyridine

Conditions	Yield
Stage #1: methoxypropanol With sodium hydride In N,N-dimethyl-formamide for 0.666667h; Stage #2: 2-bromo-6-iodo-3-methoxypyridine In N,N-dimethyl-formamide at 100℃; for 3h;	77%

methoxypropanol (1589-49-7) + C66H4O3 (273214-08-7) → C70H14O5

Conditions	Yield
In toluene at 60℃; for 5h; Esterification;	76%

methoxypropanol (1589-49-7) + methyl 4-bromo-3-hydroxybenzoate (106291-80-9) → 4-bromo-3-(3-methoxy-propoxy)-benzoic acid methyl ester (895240-78-5)

Conditions	Yield
With triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine In dichloromethane at 20℃;	75%
With triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine In dichloromethane at 20℃; Mitsunobu reaction;	75%
With triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine In dichloromethane at 20℃;

methoxypropanol (1589-49-7) + ethyl 1-(6-chloropyrimidin-4-yl)cyclopropane-1-carboxylate → ethyl 1-(6-(3-methoxypropoxy)pyrimidin-4-yl)cyclopropane-1-carboxylate

Conditions	Yield
With sodium hydride In ethanol for 5h; Reflux;	74.8%

methoxypropanol (1589-49-7) + pivaloyl chloride (3282-30-2) → 3-methoxypropyl pivalate

Conditions	Yield
With pyridine In dichloromethane at 20℃;	74%

methoxypropanol (1589-49-7) → 1-Chloro-3-methoxypropane (36215-07-3)

Conditions	Yield
With pyridine; thionyl chloride at 10 - 65℃; for 3h;	72%
With pyridine; thionyl chloride at 10 - 65℃;	72%
With pyridine; thionyl chloride at 10 - 70℃; for 8h; Inert atmosphere;	71%

methoxypropanol (1589-49-7) + tetrakis(chlorodimethylsilyl)silane (17082-82-5) → tetrakis(dimethyl(3-methoxypropoxy)silyl)silane (1293370-37-2)

Conditions	Yield
With triethylamine In hexane at 20℃; Inert atmosphere; Cooling with ice;	71%

methoxypropanol (1589-49-7) + benzylamine (100-46-9) → N-benzylpropanamide (10264-12-7)

Conditions	Yield
With dichloro(benzene)ruthenium(II) dimer; N,N-diisopropylimidazolium bromide; sodium hydride In toluene; acetonitrile for 24h; Inert atmosphere; Reflux;	71%

methoxypropanol (1589-49-7) + rac-Pro-OH (609-36-9) → 1-(3-methoxypropyl)pyrrolidine

Conditions	Yield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium hydrogencarbonate In toluene at 110℃; for 72h; Inert atmosphere;	69%

methoxypropanol (1589-49-7) + 4-amino-2-chloro-6-(trifluoromethyl)pyridine (34486-22-1) → 2-(3-methoxypropoxy)-6-(trifluoromethyl)pyridin-4-amine

Conditions	Yield
Stage #1: methoxypropanol With sodium hydride In 1,4-dioxane at 20℃; for 1h; Stage #2: 2-chloro-6-(trifluoromethyl)pyridin-4-amine In 1,4-dioxane at 110℃;	68%

Upstream product

• 503-30-0 trimethylene oxide 
• 67-56-1 methanol 
• 124-41-4 sodium methylate 
• 2806-84-0 3-methoxy-1-propanal 
• 107-02-8 acrolein 
• 110-67-8 3-Methoxypropionitrile 
• 627-30-5 1-chloro-3-hydroxypropane 
• 74-88-4 methyl iodide 
• 504-63-2 trimethyleneglycol 
• 109-99-9 tetrahydrofuran 
• 36865-41-5 3-bromopropanol methyl ether 
• 627-18-9 1-bromo-3-propanol 
• 505-22-6 1,3-dioxane 
• 3046-32-0 1-methoxy-3-vinyloxy-propane 

Downstream Products

• 36215-07-3 1-Chloro-3-methoxypropane 
• 36865-41-5 3-bromopropanol methyl ether 
• 54646-36-5 3-methoxypropyl p-toluenesulfonate 
• 141100-26-7 3-(2,6-dioxaheptyl)-3-methyloxetane 
• 96516-91-5 ((3-methoxypropoxy)methyl)benzene 
• 2806-84-0 3-methoxy-1-propanal 
• 117977-21-6 rabeprazole sulfide 
• 117977-18-1 2,3-dimethyl-4-(3-methoxypropoxy)pyridine nitroxide 
• 214543-70-1 chloromethyl [3-(methoxy)propyl] carbonate 
• 1140917-66-3 N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-2-(3-methoxypropoxy)-5-(trifluoromethyl)benzamide 
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• 61542-10-7 1-iodo-3-methoxypropane 
• 504-63-2 trimethyleneglycol 

Relevant articles and documents

Searching for the Ionized Alkene/Alkanol Complexes +./HOCH3> and +./HOCH2CH3>

Experiments on a variety of isomeric +. and +. ions have failed to produce direct evidence for the involvement of the complex ions +./HOCH3> and +./HOC2H5>.For the isomers studied, the rearrangements prior to their dissociation of lowest energy requirement (loss of H2O and C2H5., respectively) are proposed to involve distonic and ylid ions.

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A HPPO by-product recycling synthetic 1, 3 - propanediol (by machine translation)

The invention belongs to the technical field of organic chemical industry, relates to a HPPO by-product recycling synthetic 1, 3 - propanediol, more specifically, relates to a propylene HPPO process with methanol the reaction product of propylene glycol monomethyl ether as the raw material, and sequentially passes through the dewatering, borohydrite oxidation, hydrolysis of the three-step reaction synthesizes the high value added 1, 3 - propylene glycol, 1, 3 - propylene glycol total yield of 80% or more, purity 99.5% or more, the invention has the simple process route, rationalization of resources use, 1, 3 - propylene glycol yield and purity and the like. (by machine translation)

CONTROLLED RELEASE PREPARATION

A controlled release preparation wherein the release of active ingredient is controlled, which releases an active ingredient for an extended period of time by staying or slowly migrating in the gastrointestinal tract, is provided by means such as capsulating a tablet, granule or fine granule wherein the release of active ingredient is controlled and a gel-forming polymer. Said tablet, granule or fine granule has a release-controlled coating-layer formed on a core particle containing an active ingredient.