(4-fluorophenyl)-{3-propyl-4-[3-(1,2,3,4-tetrahydroquinolin-5-yloxy)propoxy]phenyl}methanone

Base Information

Chemical Name:(4-fluorophenyl)-{3-propyl-4-[3-(1,2,3,4-tetrahydroquinolin-5-yloxy)propoxy]phenyl}methanone
CAS No.:1257600-90-0
Molecular Formula:C₂₈H₃₀FNO₃
Molecular Weight:447.55
Hs Code.:

Synonyms:(4-fluorophenyl)-{3-propyl-4-[3-(1,2,3,4-tetrahydroquinolin-5-yloxy)propoxy]phenyl}methanone

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Chemical Property of (4-fluorophenyl)-{3-propyl-4-[3-(1,2,3,4-tetrahydroquinolin-5-yloxy)propoxy]phenyl}methanone

Chemical Property:

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Technology Process of (4-fluorophenyl)-{3-propyl-4-[3-(1,2,3,4-tetrahydroquinolin-5-yloxy)propoxy]phenyl}methanone

There total 3 articles about (4-fluorophenyl)-{3-propyl-4-[3-(1,2,3,4-tetrahydroquinolin-5-yloxy)propoxy]phenyl}methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 874988-14-4
(4-fluoro-phenyl)-(4-hydroxy-3-propyl-phenyl)-methanone

: 1257600-86-4
5-(3-chloropropoxy)-1,2,3,4-tetrahydroquinoline

: 1257600-90-0
(4-fluorophenyl)-{3-propyl-4-[3-(1,2,3,4-tetrahydroquinolin-5-yloxy)propoxy]phenyl}methanone

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 120 ℃; for 4h; Inert atmosphere;
DOI:10.1002/cmdc.201000194

Reference yield:

: 578-67-6
quinolin-5-ol

: 1257600-90-0
(4-fluorophenyl)-{3-propyl-4-[3-(1,2,3,4-tetrahydroquinolin-5-yloxy)propoxy]phenyl}methanone

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; potassium iodide / acetone / 6 h / Reflux; Inert atmosphere

2: boron trifluoride diethyl etherate; sodium cyanoborohydride / methanol / 1 h / Reflux; Inert atmosphere

3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 4 h / 120 °C / Inert atmosphere

With boron trifluoride diethyl etherate; sodium cyanoborohydride; potassium carbonate; potassium iodide; In methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1002/cmdc.201000194

Reference yield:

: 5374-96-9
5-(3-chloropropoxy)quinoline

: 1257600-90-0
(4-fluorophenyl)-{3-propyl-4-[3-(1,2,3,4-tetrahydroquinolin-5-yloxy)propoxy]phenyl}methanone

Guidance literature:: Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate; sodium cyanoborohydride / methanol / 1 h / Reflux; Inert atmosphere

2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 4 h / 120 °C / Inert atmosphere

With boron trifluoride diethyl etherate; sodium cyanoborohydride; potassium carbonate; potassium iodide; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201000194