3-[5-(3-{4-[4-(2-methoxyethoxy)benzoyl]-2-propylphenoxy}propoxy)-3,4-dihydro-2H-quinolin-1-yl]propionic acid

Base Information

• Chemical Name: 3-[5-(3-{4-[4-(2-methoxyethoxy)benzoyl]-2-propylphenoxy}propoxy)-3,4-dihydro-2H-quinolin-1-yl]propionic acid
• CAS No.: 1257600-70-6
• Molecular Formula: C₃₄H₄₁NO₇
• Molecular Weight: 575.702
• Mol file: 1257600-70-6.mol

Synonyms:

Chemical Property of 3-[5-(3-{4-[4-(2-methoxyethoxy)benzoyl]-2-propylphenoxy}propoxy)-3,4-dihydro-2H-quinolin-1-yl]propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[5-(3-{4-[4-(2-methoxyethoxy)benzoyl]-2-propylphenoxy}propoxy)-3,4-dihydro-2H-quinolin-1-yl]propionic acid

There total 5 articles about 3-[5-(3-{4-[4-(2-methoxyethoxy)benzoyl]-2-propylphenoxy}propoxy)-3,4-dihydro-2H-quinolin-1-yl]propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-methoxy-ethanol (109-86-4,95507-80-5) + 3-(5-{3-[4-(4-fluorobenzoyl)-2-propylphenoxy]propoxy}-3,4-dihydro-2H-quinolin-1-yl)propionitrile (1257600-92-2) → 3-[5-(3-{4-[4-(2-methoxyethoxy)benzoyl]-2-propylphenoxy}propoxy)-3,4-dihydro-2H-quinolin-1-yl]propionic acid (1257600-70-6)

Guidance literature:

2-methoxy-ethanol; 3-(5-{3-[4-(4-fluorobenzoyl)-2-propylphenoxy]propoxy}-3,4-dihydro-2H-quinolin-1-yl)propionitrile; With potassium hydroxide; In water; for 6h; Reflux; Inert atmosphere;

With hydrogenchloride; water;

DOI:10.1002/cmdc.201000194

Reference yield:

quinolin-5-ol (578-67-6) → 3-[5-(3-{4-[4-(2-methoxyethoxy)benzoyl]-2-propylphenoxy}propoxy)-3,4-dihydro-2H-quinolin-1-yl]propionic acid (1257600-70-6)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate; potassium iodide / acetone / 6 h / Reflux; Inert atmosphere

2: boron trifluoride diethyl etherate; sodium cyanoborohydride / methanol / 1 h / Reflux; Inert atmosphere

3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 4 h / 120 °C / Inert atmosphere

4: acetic acid; copper(l) chloride / 0.5 h / 100 °C / Inert atmosphere; Microwave irradiation

5: potassium hydroxide / water / 6 h / Reflux; Inert atmosphere

With boron trifluoride diethyl etherate; sodium cyanoborohydride; potassium carbonate; acetic acid; potassium iodide; copper(l) chloride; potassium hydroxide; In methanol; water; N,N-dimethyl-formamide; acetone;

DOI:10.1002/cmdc.201000194

Reference yield:

5-(3-chloropropoxy)quinoline (5374-96-9) → 3-[5-(3-{4-[4-(2-methoxyethoxy)benzoyl]-2-propylphenoxy}propoxy)-3,4-dihydro-2H-quinolin-1-yl]propionic acid (1257600-70-6)

Guidance literature:

Multi-step reaction with 4 steps

1: boron trifluoride diethyl etherate; sodium cyanoborohydride / methanol / 1 h / Reflux; Inert atmosphere

2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 4 h / 120 °C / Inert atmosphere

3: acetic acid; copper(l) chloride / 0.5 h / 100 °C / Inert atmosphere; Microwave irradiation

4: potassium hydroxide / water / 6 h / Reflux; Inert atmosphere

With boron trifluoride diethyl etherate; sodium cyanoborohydride; potassium carbonate; acetic acid; potassium iodide; copper(l) chloride; potassium hydroxide; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201000194

upstream raw materials:

quinolin-5-ol

(4-fluorophenyl)-{3-propyl-4-[3-(1,2,3,4-tetrahydroquinolin-5-yloxy)propoxy]phenyl}methanone

2-methoxy-ethanol

3-(5-{3-[4-(4-fluorobenzoyl)-2-propylphenoxy]propoxy}-3,4-dihydro-2H-quinolin-1-yl)propionitrile