5-chloro-2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-4-methyl-1H-pyrrole-3-carboxamide

Base Information

Chemical Name:5-chloro-2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-4-methyl-1H-pyrrole-3-carboxamide
CAS No.:1289206-65-0
Molecular Formula:C₁₇H₁₆ClN₃O₃
Molecular Weight:345.785
Hs Code.:

Synonyms:5-chloro-2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-4-methyl-1H-pyrrole-3-carboxamide

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Chemical Property of 5-chloro-2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-4-methyl-1H-pyrrole-3-carboxamide

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Technology Process of 5-chloro-2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-4-methyl-1H-pyrrole-3-carboxamide

There total 8 articles about 5-chloro-2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-4-methyl-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1289207-51-7
5-chloro-2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-4-methyl-1H-pyrrole-3-carbonitrile

: 1289206-65-0
5-chloro-2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-4-methyl-1H-pyrrole-3-carboxamide

: 1289206-63-8
5-chloro-2-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-1-(4-hydroxyphenyl)-4-methyl-1H-pyrrole-3-carboximidamide

Guidance literature:: With hydroxylamine; In water; dimethyl sulfoxide; at 120 ℃; for 0.416667h; Microwave irradiation;

Reference yield:

: 616-43-3
3-methylpyrrole

: 1289206-65-0
5-chloro-2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-4-methyl-1H-pyrrole-3-carboxamide

: 1289206-63-8
5-chloro-2-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-1-(4-hydroxyphenyl)-4-methyl-1H-pyrrole-3-carboximidamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium phosphate; N,N`-dimethylethylenediamine / copper(l) iodide / toluene / 16 h / 110 °C / Inert atmosphere

2.1: N-Bromosuccinimide / acetonitrile / 0.17 h / 0 °C

3.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 °C

4.1: N-chloro-succinimide / acetonitrile / 16 h

5.1: N-Bromosuccinimide / acetonitrile / 16 h

6.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.33 h / 140 °C / Microwave irradiation

7.1: boron tribromide / dichloromethane / 5 h / 0 - 20 °C

8.1: hydroxylamine / water; dimethyl sulfoxide / 0.42 h / 120 °C / Microwave irradiation

With potassium phosphate; N-chloro-succinimide; N-Bromosuccinimide; n-butyllithium; hydroxylamine; boron tribromide; potassium carbonate; N,N`-dimethylethylenediamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile;

Reference yield:

: 1289207-45-9
1-(4-methoxyphenyl)-3-methyl-1H-pyrrole

: 1289206-65-0
5-chloro-2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-4-methyl-1H-pyrrole-3-carboxamide

: 1289206-63-8
5-chloro-2-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-1-(4-hydroxyphenyl)-4-methyl-1H-pyrrole-3-carboximidamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide / acetonitrile / 0.17 h / 0 °C

2.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C

3.1: N-chloro-succinimide / acetonitrile / 16 h

4.1: N-Bromosuccinimide / acetonitrile / 16 h

5.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.33 h / 140 °C / Microwave irradiation

6.1: boron tribromide / dichloromethane / 5 h / 0 - 20 °C

7.1: hydroxylamine / water; dimethyl sulfoxide / 0.42 h / 120 °C / Microwave irradiation

With N-chloro-succinimide; N-Bromosuccinimide; n-butyllithium; hydroxylamine; boron tribromide; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; acetonitrile;