{3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]imidazo[1,5-a]pyridin-1-yl}acetic acid

Base Information

Chemical Name:{3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]imidazo[1,5-a]pyridin-1-yl}acetic acid
CAS No.:1420071-23-3
Molecular Formula:C₂₃H₂₂F₃N₃O₃
Molecular Weight:445.441
Hs Code.:

Synonyms:{3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]imidazo[1,5-a]pyridin-1-yl}acetic acid

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Chemical Property of {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]imidazo[1,5-a]pyridin-1-yl}acetic acid

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Technology Process of {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]imidazo[1,5-a]pyridin-1-yl}acetic acid

There total 10 articles about {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]imidazo[1,5-a]pyridin-1-yl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1420070-88-7
ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]imidazo[1,5-a]pyridin-1-yl}acetate

: 1420071-23-3
{3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]imidazo[1,5-a]pyridin-1-yl}acetic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 2.5h;

Reference yield:

: 1000396-44-0
(Z)-3-amino-3-pyridin-2-ylacrylic acid ethyl ester

: 1420071-23-3
{3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]imidazo[1,5-a]pyridin-1-yl}acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid; 20% palladium hydroxide-activated charcoal; hydrogen / ethanol / 5 h / 20 °C / 724.03 Torr

2.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / acetic acid butyl ester / 3 h / 20 °C / Reflux

2.2: 20 °C / pH 9

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 55 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane / 6 h / 100 °C / Schlenk technique; Sealed tube; Inert atmosphere

5.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 1 h / 20 °C

5.2: pH 4

With N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium hydroxide monohydrate; 20% palladium hydroxide-activated charcoal; water; hydrogen; caesium carbonate; acetic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In tetrahydrofuran; 1,4-dioxane; ethanol; acetic acid butyl ester; N,N-dimethyl-formamide;

Reference yield:

: 77742-21-3
ethyl (+/-)-3-amino-3-(2-pyridyl)propanoate

: 1420071-23-3
{3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]imidazo[1,5-a]pyridin-1-yl}acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / acetic acid butyl ester / 3 h / 20 °C / Reflux

1.2: 20 °C / pH 9

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 55 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane / 6 h / 100 °C / Schlenk technique; Sealed tube; Inert atmosphere

4.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 1 h / 20 °C

4.2: pH 4

With N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium hydroxide monohydrate; water; caesium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In tetrahydrofuran; 1,4-dioxane; acetic acid butyl ester; N,N-dimethyl-formamide;