ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]imidazo[1,5-a]pyridin-1-yl}acetate

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Chemical Name:ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]imidazo[1,5-a]pyridin-1-yl}acetate
CAS No.:1420070-88-7
Molecular Formula:C₂₅H₂₆F₃N₃O₃
Molecular Weight:473.495
Hs Code.:

Synonyms:ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]imidazo[1,5-a]pyridin-1-yl}acetate

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Chemical Property of ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]imidazo[1,5-a]pyridin-1-yl}acetate

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Technology Process of ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]imidazo[1,5-a]pyridin-1-yl}acetate

There total 9 articles about ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]imidazo[1,5-a]pyridin-1-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1219936-26-1
N-ethyl-N-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

: 1420070-87-6
ethyl (3-bromoimidazo[1,5-a]pyridin-1-yl)acetate

: 1420070-88-7
ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]imidazo[1,5-a]pyridin-1-yl}acetate

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,4-dioxane; at 100 ℃; for 6h; Inert atmosphere;

Reference yield:

: 1000396-44-0
(Z)-3-amino-3-pyridin-2-ylacrylic acid ethyl ester

: 1420070-88-7
ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]imidazo[1,5-a]pyridin-1-yl}acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid; 20% palladium hydroxide-activated charcoal; hydrogen / ethanol / 5 h / 20 °C / 724.03 Torr

2.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / acetic acid butyl ester / 3 h / 20 °C / Reflux

2.2: 20 °C / pH 9

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 55 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane / 6 h / 100 °C / Schlenk technique; Sealed tube; Inert atmosphere

With N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 20% palladium hydroxide-activated charcoal; hydrogen; caesium carbonate; acetic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In 1,4-dioxane; ethanol; acetic acid butyl ester; N,N-dimethyl-formamide;

Reference yield:

: 77742-21-3
ethyl (+/-)-3-amino-3-(2-pyridyl)propanoate

: 1420070-88-7
ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]imidazo[1,5-a]pyridin-1-yl}acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / acetic acid butyl ester / 3 h / 20 °C / Reflux

1.2: 20 °C / pH 9

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 55 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane / 6 h / 100 °C / Schlenk technique; Sealed tube; Inert atmosphere

With N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In 1,4-dioxane; acetic acid butyl ester; N,N-dimethyl-formamide;