(2S,3R,17R,18S)-3,17-diphenyl-1,2,18-trimethyl-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane

Base Information

Chemical Name:(2S,3R,17R,18S)-3,17-diphenyl-1,2,18-trimethyl-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane
CAS No.:150125-97-6
Molecular Formula:C₂₇H₄₀N₂O₄
Molecular Weight:456.626
Hs Code.:

Synonyms:(2S,3R,17R,18S)-3,17-diphenyl-1,2,18-trimethyl-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane

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Chemical Property of (2S,3R,17R,18S)-3,17-diphenyl-1,2,18-trimethyl-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane

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Technology Process of (2S,3R,17R,18S)-3,17-diphenyl-1,2,18-trimethyl-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane

There total 3 articles about (2S,3R,17R,18S)-3,17-diphenyl-1,2,18-trimethyl-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 150125-85-2
(2S,3R,17R,18S)-3,17-diphenyl-10-(p-tolylsulfonyl)-1,2,18-trimethyl-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane

: 150125-97-6
(2S,3R,17R,18S)-3,17-diphenyl-1,2,18-trimethyl-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;
DOI:10.1021/jo00068a029

Reference yield:

: 118187-55-6
N,N-bis<2-<2-<(p-tolylsulfonyl)oxy>ethoxy>ethyl>-p-toluenesulfonamide

: 150125-97-6
(2S,3R,17R,18S)-3,17-diphenyl-1,2,18-trimethyl-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) THF, mineral oil, reflux, 2.) reflux

2: 67 percent / LiAlH₄ / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran;
DOI:10.1021/jo00068a029

Reference yield:

: 72358-83-9,63413-83-2
N,N-bis<2-(2-hydroxyethoxy)ethyl>-4-methylbenzenesulfonamide

: 150125-97-6
(2S,3R,17R,18S)-3,17-diphenyl-1,2,18-trimethyl-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / triethylamine / CH₂Cl₂ / 48 h / 5 °C

2: 1.) NaH / 1.) THF, mineral oil, reflux, 2.) reflux

3: 67 percent / LiAlH₄ / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00068a029