(2S,3R,17R,18S)-3,17-diphenyl-10-(p-tolylsulfonyl)-1,2,18-trimethyl-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane

Base Information

• Chemical Name: (2S,3R,17R,18S)-3,17-diphenyl-10-(p-tolylsulfonyl)-1,2,18-trimethyl-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane
• CAS No.: 150125-85-2
• Molecular Formula: C₃₄H₄₆N₂O₆S
• Molecular Weight: 610.815

Synonyms:(2S,3R,17R,18S)-3,17-diphenyl-10-(p-tolylsulfonyl)-1,2,18-trimethyl-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane

Chemical Property of (2S,3R,17R,18S)-3,17-diphenyl-10-(p-tolylsulfonyl)-1,2,18-trimethyl-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane

Chemical Property:

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Technology Process of (2S,3R,17R,18S)-3,17-diphenyl-10-(p-tolylsulfonyl)-1,2,18-trimethyl-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane

There total 2 articles about (2S,3R,17R,18S)-3,17-diphenyl-10-(p-tolylsulfonyl)-1,2,18-trimethyl-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-bis<2-(2-hydroxyethoxy)ethyl>-4-methylbenzenesulfonamide (72358-83-9,63413-83-2) → (2S,3R,17R,18S)-3,17-diphenyl-10-(p-tolylsulfonyl)-1,2,18-trimethyl-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane (150125-85-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / triethylamine / CH₂Cl₂ / 48 h / 5 °C

2: 1.) NaH / 1.) THF, mineral oil, reflux, 2.) reflux

With sodium hydride; triethylamine; In dichloromethane;

DOI:10.1021/jo00068a029

Reference yield:

N,N-bis<2-<2-<(p-tolylsulfonyl)oxy>ethoxy>ethyl>-p-toluenesulfonamide (118187-55-6) + (1R,2S)-2-[((R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amino]-1-phenyl-propan-1-ol → (2S,3R,17R,18S)-3,17-diphenyl-10-(p-tolylsulfonyl)-1,2,18-trimethyl-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane (150125-85-2)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) THF, mineral oil, reflux, 2.) reflux;

DOI:10.1021/jo00068a029

Reference yield: 67.0%

(2S,3R,17R,18S)-3,17-diphenyl-10-(p-tolylsulfonyl)-1,2,18-trimethyl-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane (150125-85-2) → (2S,3R,17R,18S)-3,17-diphenyl-1,2,18-trimethyl-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane (150125-97-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

DOI:10.1021/jo00068a029

upstream raw materials:

N,N-bis<2-<2-<(p-tolylsulfonyl)oxy>ethoxy>ethyl>-p-toluenesulfonamide

N,N-bis<2-(2-hydroxyethoxy)ethyl>-4-methylbenzenesulfonamide

Downstream raw materials:

(2S,3R,17R,18S)-3,17-diphenyl-1,2,18-trimethyl-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane

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