methyl 4-((4-fluoro-N-isopropylphenylsulfonamido)methyl)benzoate

Base Information

• Chemical Name: methyl 4-((4-fluoro-N-isopropylphenylsulfonamido)methyl)benzoate
• CAS No.: 1372174-70-3
• Molecular Formula: C₁₈H₂₀FNO₄S
• Molecular Weight: 365.426
• Mol file: 1372174-70-3.mol

Synonyms:methyl 4-((4-fluoro-N-isopropylphenylsulfonamido)methyl)benzoate

Chemical Property of methyl 4-((4-fluoro-N-isopropylphenylsulfonamido)methyl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-((4-fluoro-N-isopropylphenylsulfonamido)methyl)benzoate

There total 3 articles about methyl 4-((4-fluoro-N-isopropylphenylsulfonamido)methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

methyl 4-(((4-fluorophenyl)sulfonamido)methyl)benzoate (935860-58-5) + isopropyl alcohol (67-63-0,8013-70-5) → methyl 4-((4-fluoro-N-isopropylphenylsulfonamido)methyl)benzoate (1372174-70-3)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

methyl 4-(aminomethyl)benzoate hydrochloride (6232-11-7) → methyl 4-((4-fluoro-N-isopropylphenylsulfonamido)methyl)benzoate (1372174-70-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 20 °C

With di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane;

Reference yield:

4-Fluorobenzenesulfonyl chloride (349-88-2) → methyl 4-((4-fluoro-N-isopropylphenylsulfonamido)methyl)benzoate (1372174-70-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 20 °C

With di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane;

upstream raw materials:

methyl 4-(((4-fluorophenyl)sulfonamido)methyl)benzoate

isopropyl alcohol

methyl 4-(aminomethyl)benzoate hydrochloride

4-Fluorobenzenesulfonyl chloride