5-(3,4-Dichlorophenyl)-5-(2-methanesulphonyloxyethyl)-2(1H)-piperidone

Base Information

Chemical Name:5-(3,4-Dichlorophenyl)-5-(2-methanesulphonyloxyethyl)-2(1H)-piperidone
CAS No.:178310-95-7
Molecular Formula:C₁₄H₁₇Cl₂NO₄S
Molecular Weight:366.265
Hs Code.:

Synonyms:5-(3,4-Dichlorophenyl)-5-(2-methanesulphonyloxyethyl)-2(1H)-piperidone

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Chemical Property of 5-(3,4-Dichlorophenyl)-5-(2-methanesulphonyloxyethyl)-2(1H)-piperidone

Chemical Property:

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Technology Process of 5-(3,4-Dichlorophenyl)-5-(2-methanesulphonyloxyethyl)-2(1H)-piperidone

There total 6 articles about 5-(3,4-Dichlorophenyl)-5-(2-methanesulphonyloxyethyl)-2(1H)-piperidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 124-63-0
methanesulfonyl chloride

: 178310-94-6
5-(3,4-Dichlorophenyl)-5-(2-hydroxyethyl)-2(1H)-piperidone

: 178310-95-7
5-(3,4-Dichlorophenyl)-5-(2-methanesulphonyloxyethyl)-2(1H)-piperidone

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2.5h;
DOI:10.1021/jm0209331

Reference yield:

: 3218-49-3
3,4-dichloro-benzeneacetonitrile

: 178310-95-7
5-(3,4-Dichlorophenyl)-5-(2-methanesulphonyloxyethyl)-2(1H)-piperidone

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / tetrahydrofuran / 0.5 h

1.2: 34 percent / tetrahydrofuran / 20 °C

2.1: LDA / tetrahydrofuran / -78 - 20 °C

2.2: 61 percent / tertbutylammonium iodide / tetrahydrofuran / 20 °C

3.1: 75 percent / H₂; NH₃ / Raney nickel / ethanol / 14 h / 20 °C

4.1: 61 percent / HCl / methanol / 2 h / 20 °C

5.1: 58 percent / NEt₃ / CH₂Cl₂ / 2.5 h / 20 °C

With hydrogenchloride; ammonia; hydrogen; sodium hydride; triethylamine; lithium diisopropyl amide; nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/jm0209331

Reference yield:

: 135936-16-2
α-[2-(Tetrahydropyran-2-yloxy)ethyl]-3,4-dichlorophenyl-acetonitrile

: 178310-95-7
5-(3,4-Dichlorophenyl)-5-(2-methanesulphonyloxyethyl)-2(1H)-piperidone

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran / -78 - 20 °C

1.2: 61 percent / tertbutylammonium iodide / tetrahydrofuran / 20 °C

2.1: 75 percent / H₂; NH₃ / Raney nickel / ethanol / 14 h / 20 °C

3.1: 61 percent / HCl / methanol / 2 h / 20 °C

4.1: 58 percent / NEt₃ / CH₂Cl₂ / 2.5 h / 20 °C

With hydrogenchloride; ammonia; hydrogen; triethylamine; lithium diisopropyl amide; nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/jm0209331