tert-butyl and 4-{2-carbamoyl-5-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]phenylamino}cyclohexyl ester of malonic acid

Base Information

Chemical Name:tert-butyl and 4-{2-carbamoyl-5-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]phenylamino}cyclohexyl ester of malonic acid
CAS No.:1190422-67-3
Molecular Formula:C₃₉H₃₈FN₅O₅
Molecular Weight:675.76
Hs Code.:

Synonyms:tert-butyl and 4-{2-carbamoyl-5-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]phenylamino}cyclohexyl ester of malonic acid

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Chemical Property of tert-butyl and 4-{2-carbamoyl-5-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]phenylamino}cyclohexyl ester of malonic acid

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Technology Process of tert-butyl and 4-{2-carbamoyl-5-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]phenylamino}cyclohexyl ester of malonic acid

There total 10 articles about tert-butyl and 4-{2-carbamoyl-5-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]phenylamino}cyclohexyl ester of malonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40052-13-9
mono-tert-butyl malonate

: 1187617-31-7
4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]-2-(4-trans-hydroxycyclohexylamino)benzamide

: 1190422-67-3
tert-butyl and 4-{2-carbamoyl-5-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]phenylamino}cyclohexyl ester of malonic acid

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 20h; Inert atmosphere;

Reference yield:

: 93583-49-4
methyl carbazole-4-carboxylate

: 1190422-67-3
tert-butyl and 4-{2-carbamoyl-5-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]phenylamino}cyclohexyl ester of malonic acid

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydride / N,N-dimethyl-formamide; petroleum jelly / 20 °C / Inert atmosphere

2: sodium t-butanolate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / toluene / 0.5 h / 115 °C / microwave irradiation

3: sodium hydroxide; methanol / 7 h / Reflux

4: N-ethyl-N,N-diisopropylamine; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 3.5 h / 20 °C

5: acetic acid / 1 h / Reflux

6: sodium hydroxide; water; dihydrogen peroxide / ethanol; dimethyl sulfoxide / 0.25 h / 20 °C

7: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

With methanol; dmap; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; water; dihydrogen peroxide; sodium hydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sodium t-butanolate; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In petroleum jelly; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 52602-39-8
9H-carbazol-4-ol

: 1190422-67-3
tert-butyl and 4-{2-carbamoyl-5-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]phenylamino}cyclohexyl ester of malonic acid

Guidance literature:: Multi-step reaction with 9 steps

1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 8 h / 50 °C / 1500.15 Torr / autoclave

3: sodium hydride / N,N-dimethyl-formamide; petroleum jelly / 20 °C / Inert atmosphere

4: sodium t-butanolate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / toluene / 0.5 h / 115 °C / microwave irradiation

5: sodium hydroxide; methanol / 7 h / Reflux

6: N-ethyl-N,N-diisopropylamine; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 3.5 h / 20 °C

7: acetic acid / 1 h / Reflux

8: sodium hydroxide; water; dihydrogen peroxide / ethanol; dimethyl sulfoxide / 0.25 h / 20 °C

9: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

With methanol; dmap; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; water; dihydrogen peroxide; sodium hydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sodium t-butanolate; 1,1'-bis-(diphenylphosphino)ferrocene; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In petroleum jelly; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;