4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]-2-(4-trans-hydroxycyclohexylamino)benzamide

Base Information

Chemical Name:4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]-2-(4-trans-hydroxycyclohexylamino)benzamide
CAS No.:1187617-31-7
Molecular Formula:C₃₂H₂₈FN₅O₂
Molecular Weight:533.605
Hs Code.:

Synonyms:4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]-2-(4-trans-hydroxycyclohexylamino)benzamide

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Chemical Property of 4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]-2-(4-trans-hydroxycyclohexylamino)benzamide

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Technology Process of 4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]-2-(4-trans-hydroxycyclohexylamino)benzamide

There total 9 articles about 4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]-2-(4-trans-hydroxycyclohexylamino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187617-37-3
4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]-2-(4-trans-hydroxycyclohexylamino)benzonitrile

: 1187617-31-7
4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]-2-(4-trans-hydroxycyclohexylamino)benzamide

Guidance literature:: With water; dihydrogen peroxide; sodium hydroxide; In ethanol; dimethyl sulfoxide; at 20 ℃; for 0.25h;

Reference yield:

: 93583-49-4
methyl carbazole-4-carboxylate

: 1187617-31-7
4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]-2-(4-trans-hydroxycyclohexylamino)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / N,N-dimethyl-formamide; petroleum jelly / 20 °C / Inert atmosphere

2: sodium t-butanolate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / toluene / 0.5 h / 115 °C / microwave irradiation

3: sodium hydroxide; methanol / 7 h / Reflux

4: N-ethyl-N,N-diisopropylamine; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 3.5 h / 20 °C

5: acetic acid / 1 h / Reflux

6: sodium hydroxide; water; dihydrogen peroxide / ethanol; dimethyl sulfoxide / 0.25 h / 20 °C

With methanol; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; water; dihydrogen peroxide; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sodium t-butanolate; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In petroleum jelly; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 52602-39-8
9H-carbazol-4-ol

: 1187617-31-7
4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]-2-(4-trans-hydroxycyclohexylamino)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 8 h / 50 °C / 1500.15 Torr / autoclave

3: sodium hydride / N,N-dimethyl-formamide; petroleum jelly / 20 °C / Inert atmosphere

4: sodium t-butanolate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / toluene / 0.5 h / 115 °C / microwave irradiation

5: sodium hydroxide; methanol / 7 h / Reflux

6: N-ethyl-N,N-diisopropylamine; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 3.5 h / 20 °C

7: acetic acid / 1 h / Reflux

8: sodium hydroxide; water; dihydrogen peroxide / ethanol; dimethyl sulfoxide / 0.25 h / 20 °C

With methanol; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; water; dihydrogen peroxide; sodium hydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sodium t-butanolate; 1,1'-bis-(diphenylphosphino)ferrocene; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In petroleum jelly; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;