4-{7-{[(3S)-3-amino-1-pyrrolidinyl]carbonyl}-1-ethyl-6-[(4-fluorophenyl)oxy]-1H-imidazo[4,5-c]pyridin-2-yl}-furazan-3-amine

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Chemical Name:4-{7-{[(3S)-3-amino-1-pyrrolidinyl]carbonyl}-1-ethyl-6-[(4-fluorophenyl)oxy]-1H-imidazo[4,5-c]pyridin-2-yl}-furazan-3-amine
CAS No.:850180-91-5
Molecular Formula:C₂₁H₂₁FN₈O₃
Molecular Weight:452.448
Hs Code.:

Synonyms:4-{7-{[(3S)-3-amino-1-pyrrolidinyl]carbonyl}-1-ethyl-6-[(4-fluorophenyl)oxy]-1H-imidazo[4,5-c]pyridin-2-yl}-furazan-3-amine

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Chemical Property of 4-{7-{[(3S)-3-amino-1-pyrrolidinyl]carbonyl}-1-ethyl-6-[(4-fluorophenyl)oxy]-1H-imidazo[4,5-c]pyridin-2-yl}-furazan-3-amine

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Technology Process of 4-{7-{[(3S)-3-amino-1-pyrrolidinyl]carbonyl}-1-ethyl-6-[(4-fluorophenyl)oxy]-1H-imidazo[4,5-c]pyridin-2-yl}-furazan-3-amine

There total 2 articles about 4-{7-{[(3S)-3-amino-1-pyrrolidinyl]carbonyl}-1-ethyl-6-[(4-fluorophenyl)oxy]-1H-imidazo[4,5-c]pyridin-2-yl}-furazan-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 850180-92-6
2-(4-amino-furazan-3-yl)-1-ethyl-6-[(4-fluorophenyl)oxy]-1H-imidazo[4,5-c]pyridine-7-carboxylic acid

: 122536-76-9,140629-77-2
3(S)-(tert-butoxycarbonylamino)pyrrolidine

: 850180-91-5
4-{7-{[(3S)-3-amino-1-pyrrolidinyl]carbonyl}-1-ethyl-6-[(4-fluorophenyl)oxy]-1H-imidazo[4,5-c]pyridin-2-yl}-furazan-3-amine

Guidance literature:: 2-(4-amino-furazan-3-yl)-1-ethyl-6-[(4-fluorophenyl)oxy]-1H-imidazo[4,5-c]pyridine-7-carboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃;

3(S)-(tert-butoxycarbonylamino)pyrrolidine; In N,N-dimethyl-formamide;

With trifluoroacetic acid; In dichloromethane; for 1h;

Reference yield:

: 31872-63-6
3-bromo-4-chloro-5-nitropyridine

: 850180-91-5
4-{7-{[(3S)-3-amino-1-pyrrolidinyl]carbonyl}-1-ethyl-6-[(4-fluorophenyl)oxy]-1H-imidazo[4,5-c]pyridin-2-yl}-furazan-3-amine

Guidance literature:: Multi-step reaction with 10 steps

1.1: tert.-butylhydroperoxide; potassium tert-butylate; ammonia / tetrahydrofuran; decane / 2 h / -35 °C

2.1: trichlorophosphate / acetonitrile / 90 °C

3.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

4.1: potassium carbonate / acetonitrile / 80 °C

5.1: hydrogenchloride; tin(ll) chloride / ethanol / 2 h / 20 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

7.1: acetic acid / 1 h / 100 °C

8.1: hydrogenchloride; sodium nitrite / methanol / 1 h

8.2: 1 h / 100 °C

8.3: 3 h / 140 °C

9.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.25 h / -78 °C

9.2: -78 - 20 °C

10.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 20 °C

10.3: 1 h

With hydrogenchloride; tert.-butylhydroperoxide; n-butyllithium; potassium tert-butylate; ammonia; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; diisopropylamine; 1,1'-carbonyldiimidazole; tin(ll) chloride; sodium nitrite; trichlorophosphate; In tetrahydrofuran; methanol; decane; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;