31872-63-6

Usage

Uses

Used in Pharmaceutical Synthesis:
3-Bromo-4-chloro-5-nitropyridine is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with enhanced therapeutic properties.
Used in Agrochemical Production:
In the agrochemical industry, 3-Bromo-4-chloro-5-nitropyridine is utilized as a building block for the creation of new agrochemicals, potentially improving crop protection and yield.
Used in Dye Manufacturing:
3-Bromo-4-chloro-5-nitropyridine is employed as a chemical intermediate in the production of dyes, contributing to the development of novel colorants for various industries.
Used in Fine Chemicals and Specialty Materials:
3-BROMO-4-CHLORO-5-NITROPYRIDINE is used as an intermediate in the manufacture of various fine chemicals and specialty materials, where its unique properties can be leveraged to create high-value products.
Used in Pest Control and Antimicrobial Products:
3-Bromo-4-chloro-5-nitropyridine is used as an active ingredient in pest control and antimicrobial products due to its antimicrobial and antifungal properties, providing effective solutions for controlling pests and microorganisms.
It is crucial to handle 3-Bromo-4-chloro-5-nitropyridine with care, as it may pose health risks if ingested, inhaled, or if it comes into contact with the skin or eyes. Proper safety measures should be taken during its use and storage to mitigate potential hazards.

InChI:InChI=1/C5H2BrClN2O2/c6-3-1-8-2-4(5(3)7)9(10)11/h1-2H

Upstream product

• 31872-65-8 3-bromo-5-nitropyridin-4-ol 
• 5435-54-1 4-hydroxy-3-nitropyridine 
• 15590-90-6 3-nitro-4(1H)-pyridinone 
• 31872-65-8 3-bromo-5-nitro-4-pyridone 

Downstream Products

• 31872-76-1 3-bromo-4-methoxy-5-nitropyridine 
• 89284-05-9 4-amino-3-bromo-5-nitropyridine 
• 99866-33-8 3-bromo-5-nitro-4-phenylsulfanyl-pyridine 
• 861024-04-6 5-bromo-N⁴-butyl-2-chloro-pyridine-3,4-diyldiamine 
• 861024-05-7 5-bromo-N⁴-butyl-pyridine-3,4-diyldiamine 
• 99867-26-2 2-(3-bromo-5-nitro-[4]pyridylamino)-phenol 
• 122338-12-9 4-(7-bromo-thiazolo[4,5-c]pyridin-2-yl)-aniline 
• 109162-91-6 7-bromo-2-(4-nitro-phenyl)-thiazolo[4,5-c]pyridine 
• 108993-52-8 4-nitro-thiobenzoic acid S-(3-amino-5-bromo-[4]pyridyl ester) 
• 69872-15-7 3-bromo-4-methyl-5-nitropyridine 
• 850892-97-6 tert-butyl 4-bromo-1H-pyrrolo[2,3-c]pyridine-1-carboxylate 
• 69872-17-9 4-bromo-1H-pyrrolo[2,3-c]pyridine 
• 1620240-04-1 benzyl [(3S)-1-(3-cyano-5-nitropyridin-4-yl)piperidin-3-yl]carbamate 
• 1620240-05-2 benzyl [(3S)-1-(3-amino-5-cyanopyridin-4-yl)piperidin-3-yl]carbamate 

Relevant academic research and scientific papers

1-(2-hydroxy-2-methyl-3-phenoxypropanoyl)indoline-4-carbonitrile derivatives as potent and tissue selective androgen receptor modulators

We present a novel series of selective androgen receptor modulators (SARMs) which shows excellent biological activity and physical properties. 1-(2-Hydroxy-2-methyl-3-phenoxypropanoyl)-indoline-4-carbonitriles showed potent binding to the androgen receptor (AR) and activated AR-mediated transcription in vitro. Representative compounds demonstrated diminished activity in promoting the intramolecular interaction between the AR carboxyl (C) and amino (N) termini. This N/C-termini interaction is a biomarker assay for the undesired androgenic responses in vivo. In orchidectomized rats, daily administration of a lead compound from this series showed anabolic activity by increasing levator ani muscle weight. Importantly, minimal androgenic effects (increased tissue weights) were observed in the prostate and seminal vesicles, along with minimal repression of circulating luteinizing hormone (LH) levels and no change in the lipid and triglyceride levels. This lead compound completed a two week rat toxicology study, and was well tolerated at doses up to 100 mg/kg/day, the highest dose tested, for 14 consecutive days.

4 - SUBSTITUTED 1, 3 - DIHYDRO - 2H - BENZIMIDAZOL - 2 - ONE DERIVATIVES SUBSTITUTED WITH BENZIMIDAZOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS

The present invention is concerned with novel 4-substituted 1,3-dihydro-2H- benzimidazol-2-one derivatives substituted with benzimidazoles having formula (I), tautomers and stereoisomeric forms thereof, and the pharmaceutically acceptable addition salts, and the solvates thereof, wherein R4, R5, Z and Het have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.

1,3 -DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES SUBSTITUTED WITH HETEROCYCLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS

The present invention is concerned with novel 4-substituted 1,3-dihydro-2H-benzimidazol-2-one derivatives substituted with heterocycles having formula (I) tautomers and stereoisomeric forms thereof, and the pharmaceutically acceptable addition salts, and the solvates thereof, wherein R4, R5, Z and Het have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.

Azaindolines: Derisking the indoline structural alert

4-Substitued azaindolines, which are isosteres of indolines, are useful synthetic building blocks that reduce the risk of bioactivation induced idiosyncratic toxicity have been prepared. Multigram routes to 2,3-dihydro-1H-pyrrolo[2,3-c]pyridine-4-triflate 16, 2,3-dihydro-1H-pyrrolo[2,3- b]pyridine-4-carbonitrile 20 and 4-chloro-2,3-dihydro-1H-pyrrolo[2,3-d] pyridazine 30 are outlined.

METHODS FOR THE IDENTIFICATION OF PARP INTERACTING MOLECULES AND FOR PURIFICATION OF PARP PROTEINS

The present invention relates to immobilization compounds and methods useful for the identification of PARP interacting compounds or for the purification or identification of PARP proteins.

INDAZOLECARBOXAMIDE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF MALARIA

The invention relates to methods of treating or preventing malaria which comprises administering to a patient in need thereof, an effective amount of a 1H-indazole-3-carboxamide derivative of general formula (I), in the form of a base or of an addition salt with an acid, or in the form of a hydrate or of a solvate of said base or acid addition salt.

Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors

Compound corresponding to general formula (I): [image] in which, R1 represents a hydrogen or halogen atom, an NH2, NHR2, NHCOR2, NO2, CN, CH2NH2 and CH2NHR2; or alternatively R1 represents an optionally substituted phenyl or an optionally substituted heteroaromatic group; Ar represents an optionally substituted phenyl group or an optionally substituted heteroaromatic group; n represents 0, 1, 2 or 3; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. Application in therapy.

PYRROLO[3,2-B]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF

The present invention provides novel pyrrolo[3,2-b]pyridine derivatives or pharmaceutically acceptable salts thereof, processes for the preparation thereof, and compositions comprising the same. The pyrrolo[3,2-b]pyridine derivatives or pharmaceutically acceptable salts thereof of the present invention have excellent proton pump inhibition effects and possess the ability to attain a reversible proton pump inhibitory effect.

PREPARATION OF 1, 6, 7- TRISUBSTITUTED AZABENZIMIDAZOLES AS KINASE INHIBITORS

Novel inhibitors of Rho-kinases are disclosed .