31872-63-6

Basic information

• Product Name: 3-BROMO-4-CHLORO-5-NITROPYRIDINE
• Synonyms: 3-BROMO-4-CHLORO-5-NITROPYRIDINE;3-Nitro-4-chloro-5-bromopyridine;Pyridine, 3-broMo-4-chloro-5-nitro-;3-BroMo-4-chloro-5-nitropyridine HCl
• CAS NO: 31872-63-6
• Molecular Formula: C₅H₂BrClN₂O₂
• Molecular Weight: 237.44
• Product Categories: Pyridine;Boronic Acid;Pyridine Series;Heterocycle-Pyridine series
• Mol File: 31872-63-6.mol
• Article Data: 11

Chemical Properties

• Melting Point: 49-50℃
• Boiling Point: 285℃
• Flash Point: 126℃
• Appearance: /
• Density: 1.936
• Vapor Pressure: 0.00506mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -0.88±0.10(Predicted)
• CAS DataBase Reference: 3-BROMO-4-CHLORO-5-NITROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-4-CHLORO-5-NITROPYRIDINE(31872-63-6)
• EPA Substance Registry System: 3-BROMO-4-CHLORO-5-NITROPYRIDINE(31872-63-6)

Safety Data

• RIDADR: UN2811
• HazardClass: IRRITANT
• Hazardous Substances Data: 31872-63-6(Hazardous Substances Data)

Usage

General Description

3-Bromo-4-chloro-5-nitropyridine is a chemical compound with the molecular formula C5H2BrClN2O2. It is a yellow crystalline solid that is primarily used in the synthesis of pharmaceuticals, agrochemicals, and dyes. 3-BROMO-4-CHLORO-5-NITROPYRIDINE is known for its strong nitro and halogen substituents, which make it a useful building block in chemical synthesis. It is also used as an intermediate in the manufacture of various fine chemicals and specialty materials. Additionally, 3-Bromo-4-chloro-5-nitropyridine is known for its antimicrobial and antifungal properties, making it a potential ingredient in pest control and antimicrobial products. However, it is important to handle this compound with care, as it may be harmful if ingested or inhaled and can cause irritation to the skin and eyes.

InChI:InChI=1/C5H2BrClN2O2/c6-3-1-8-2-4(5(3)7)9(10)11/h1-2H

Upstream product

• 31872-65-8 3-bromo-5-nitropyridin-4-ol 
• 15590-90-6 3-nitro-4(1H)-pyridinone 
• 5435-54-1 4-hydroxy-3-nitropyridine 
• 31872-65-8 3-bromo-5-nitro-4-pyridone 

Downstream Products

• 31872-76-1 3-bromo-4-methoxy-5-nitropyridine 
• 89284-05-9 4-amino-3-bromo-5-nitropyridine 
• 99866-33-8 3-bromo-5-nitro-4-phenylsulfanyl-pyridine 
• 861024-04-6 5-bromo-N⁴-butyl-2-chloro-pyridine-3,4-diyldiamine 
• 861024-05-7 5-bromo-N⁴-butyl-pyridine-3,4-diyldiamine 
• 99867-26-2 2-(3-bromo-5-nitro-[4]pyridylamino)-phenol 
• 122338-12-9 4-(7-bromo-thiazolo[4,5-c]pyridin-2-yl)-aniline 
• 109162-91-6 7-bromo-2-(4-nitro-phenyl)-thiazolo[4,5-c]pyridine 
• 108993-52-8 4-nitro-thiobenzoic acid S-(3-amino-5-bromo-[4]pyridyl ester) 
• 69872-15-7 3-bromo-4-methyl-5-nitropyridine 
• 91394-81-9 (3-bromo-5-nitro-pyridin-4-yl)-(4-methoxy-phenyl)-amine 
• 842149-46-6 2-(4-amino-1,2,5-oxadiazol-3-yl)-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-7-ol 
• 842144-03-0 5-bromo-2-chloro-N₄-ethylpyridine-3,4-diamine 
• 842144-04-1 N-[5-romo-2-chloro-4-(ethylamino)-3-pyridinyl]-2-cyanoacetamide 

Relevant articles and documents

1-(2-hydroxy-2-methyl-3-phenoxypropanoyl)indoline-4-carbonitrile derivatives as potent and tissue selective androgen receptor modulators

We present a novel series of selective androgen receptor modulators (SARMs) which shows excellent biological activity and physical properties. 1-(2-Hydroxy-2-methyl-3-phenoxypropanoyl)-indoline-4-carbonitriles showed potent binding to the androgen receptor (AR) and activated AR-mediated transcription in vitro. Representative compounds demonstrated diminished activity in promoting the intramolecular interaction between the AR carboxyl (C) and amino (N) termini. This N/C-termini interaction is a biomarker assay for the undesired androgenic responses in vivo. In orchidectomized rats, daily administration of a lead compound from this series showed anabolic activity by increasing levator ani muscle weight. Importantly, minimal androgenic effects (increased tissue weights) were observed in the prostate and seminal vesicles, along with minimal repression of circulating luteinizing hormone (LH) levels and no change in the lipid and triglyceride levels. This lead compound completed a two week rat toxicology study, and was well tolerated at doses up to 100 mg/kg/day, the highest dose tested, for 14 consecutive days.

1,3 -DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES SUBSTITUTED WITH HETEROCYCLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS

The present invention is concerned with novel 4-substituted 1,3-dihydro-2H-benzimidazol-2-one derivatives substituted with heterocycles having formula (I) tautomers and stereoisomeric forms thereof, and the pharmaceutically acceptable addition salts, and the solvates thereof, wherein R4, R5, Z and Het have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.

METHODS FOR THE IDENTIFICATION OF PARP INTERACTING MOLECULES AND FOR PURIFICATION OF PARP PROTEINS

The present invention relates to immobilization compounds and methods useful for the identification of PARP interacting compounds or for the purification or identification of PARP proteins.