N₄-(4-morpholinophenyl)-N₆-(pyridin-3-ylmethyl)pyrido-[3,2-d]pyrimidine-4,6-diamine

Base Information

• Chemical Name: N₄-(4-morpholinophenyl)-N₆-(pyridin-3-ylmethyl)pyrido-[3,2-d]pyrimidine-4,6-diamine
• CAS No.: 1614228-99-7
• Molecular Formula: C₂₃H₂₃N₇O
• Molecular Weight: 413.482

Synonyms:N₄-(4-morpholinophenyl)-N₆-(pyridin-3-ylmethyl)pyrido-[3,2-d]pyrimidine-4,6-diamine

Chemical Property of N₄-(4-morpholinophenyl)-N₆-(pyridin-3-ylmethyl)pyrido-[3,2-d]pyrimidine-4,6-diamine

Chemical Property:

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Technology Process of N₄-(4-morpholinophenyl)-N₆-(pyridin-3-ylmethyl)pyrido-[3,2-d]pyrimidine-4,6-diamine

There total 2 articles about N₄-(4-morpholinophenyl)-N₆-(pyridin-3-ylmethyl)pyrido-[3,2-d]pyrimidine-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

3-Aminomethylpyridine (3731-52-0) + 6-chloro-N-(4-morpholinophenyl)pyrido[3,2-d]pyrimidin-4-amine (1614229-09-2) → N4-(4-morpholinophenyl)-N6-(pyridin-3-ylmethyl)pyrido-[3,2-d]pyrimidine-4,6-diamine (1614228-99-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 90 ℃; for 48h;

DOI:10.1021/jm5006429

Reference yield:

4-morpholino-4-yl-phenylamine (2524-67-6,86759-37-7) + 4,6-dichloropyrido<3,2-d>pyrimidine (175358-02-8) → N4-(4-morpholinophenyl)-N6-(pyridin-3-ylmethyl)pyrido-[3,2-d]pyrimidine-4,6-diamine (1614228-99-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 80 °C

2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 48 h / 90 °C

With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

DOI:10.1021/jm5006429

upstream raw materials:

3-Aminomethylpyridine

6-chloro-N-(4-morpholinophenyl)pyrido[3,2-d]pyrimidin-4-amine

4-morpholino-4-yl-phenylamine

4,6-dichloropyrido<3,2-d>pyrimidine

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