7-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]-2-N-dimethylaminomethyleneguanine

Base Information

Chemical Name:7-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]-2-N-dimethylaminomethyleneguanine
CAS No.:902452-74-8
Molecular Formula:C₃₅H₃₆N₆O₇
Molecular Weight:652.707
Hs Code.:

Synonyms:7-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]-2-N-dimethylaminomethyleneguanine

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Chemical Property of 7-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]-2-N-dimethylaminomethyleneguanine

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Technology Process of 7-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]-2-N-dimethylaminomethyleneguanine

There total 9 articles about 7-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]-2-N-dimethylaminomethyleneguanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 902452-70-4
7-(3-O-benzyl-2-O,4-C-methylene-β-D-ribofuranosyl)-2-N-isobutyrylguanine

: 902452-74-8
7-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]-2-N-dimethylaminomethyleneguanine

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / HCO₂H / Pd/C / methanol

2: 302 mg / NH₃ / methanol / 72 h

3: dimethylformamide

4: 490 mg / pyridine / 4 h

With pyridine; formic acid; ammonia; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2006.04.016

Reference yield:

: 902452-68-0
7-(2-O-acetyl-3-O-benzyl-4-C-methanesulfonyloxy-5-O-methanesulfonyl-β-D-erythro-pentofuranosyl)-2-N-isobutyrylguanine

: 902452-74-8
7-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]-2-N-dimethylaminomethyleneguanine

Guidance literature:: Multi-step reaction with 7 steps

1: 89 percent / NaOH / dioxane; H₂O

2: 93 percent / dimethylformamide

3: 85 percent / NaOH; pyridine / ethanol; H₂O

4: 81 percent / HCO₂H / Pd/C / methanol

5: 302 mg / NH₃ / methanol / 72 h

6: dimethylformamide

7: 490 mg / pyridine / 4 h

With pyridine; sodium hydroxide; formic acid; ammonia; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2006.04.016

Reference yield:

: 902452-69-1
7-(5-O-benzoyl-3-O-benzyl-2-O,4-C-methylene-β-D-ribofuranosyl)-2-N-isobutyrylguanine

: 902452-74-8
7-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]-2-N-dimethylaminomethyleneguanine

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / NaOH; pyridine / ethanol; H₂O

2: 81 percent / HCO₂H / Pd/C / methanol

3: 302 mg / NH₃ / methanol / 72 h

4: dimethylformamide

5: 490 mg / pyridine / 4 h

With pyridine; sodium hydroxide; formic acid; ammonia; palladium on activated charcoal; In methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2006.04.016