ethyl (2S)-2-ethoxy-3-(4-{[5-methyl-2-(5-phenylthiophen-2-yl)-1,3-oxazol-4-yl]methoxy}phenyl)propanoate

Base Information

• Chemical Name: ethyl (2S)-2-ethoxy-3-(4-{[5-methyl-2-(5-phenylthiophen-2-yl)-1,3-oxazol-4-yl]methoxy}phenyl)propanoate
• CAS No.: 696661-77-5
• Molecular Formula: C₂₈H₂₉NO₅S
• Molecular Weight: 491.608
• Mol file: 696661-77-5.mol

Synonyms:ethyl (2S)-2-ethoxy-3-(4-{[5-methyl-2-(5-phenylthiophen-2-yl)-1,3-oxazol-4-yl]methoxy}phenyl)propanoate

Chemical Property of ethyl (2S)-2-ethoxy-3-(4-{[5-methyl-2-(5-phenylthiophen-2-yl)-1,3-oxazol-4-yl]methoxy}phenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (2S)-2-ethoxy-3-(4-{[5-methyl-2-(5-phenylthiophen-2-yl)-1,3-oxazol-4-yl]methoxy}phenyl)propanoate

There total 4 articles about ethyl (2S)-2-ethoxy-3-(4-{[5-methyl-2-(5-phenylthiophen-2-yl)-1,3-oxazol-4-yl]methoxy}phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

→ ethyl (2S)-2-ethoxy-3-(4-{[5-methyl-2-(5-phenylthiophen-2-yl)-1,3-oxazol-4-yl]methoxy}phenyl)propanoate (696661-77-5)

Guidance literature:

Reference yield:

C15H12ClNOS (1310430-87-5) + ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate (222555-06-8) → ethyl (2S)-2-ethoxy-3-(4-{[5-methyl-2-(5-phenylthiophen-2-yl)-1,3-oxazol-4-yl]methoxy}phenyl)propanoate (696661-77-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 - 90 ℃; for 2h;

DOI:10.1016/j.bmcl.2011.03.020

Reference yield:

5-phenylthiophene-2-carboxaldehyde (19163-21-4) → ethyl (2S)-2-ethoxy-3-(4-{[5-methyl-2-(5-phenylthiophen-2-yl)-1,3-oxazol-4-yl]methoxy}phenyl)propanoate (696661-77-5)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; acetic acid / 1 h / 0 °C

2: trichlorophosphate / 1,2-dichloro-ethane / 14 h / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 - 90 °C

With hydrogenchloride; potassium carbonate; acetic acid; trichlorophosphate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.03.020

upstream raw materials:

5-phenylthiophene-2-carboxaldehyde

C₁₅H₁₂ClNOS

ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate

C₁₅H₁₃NO₂S

Downstream raw materials:

(S)-2-ethoxy-3-(4-((5-methyl-2-(5-phenylthiophen-2-yl)oxazol-4-yl)methoxy)phenyl)propanoic acid