1,1'-(butane-1,4-diyl)bis[hexahydro-4-phenyl-5-tosyl-1,5-diazocin-2(1H)-one]

Base Information

Chemical Name:1,1'-(butane-1,4-diyl)bis[hexahydro-4-phenyl-5-tosyl-1,5-diazocin-2(1H)-one]
CAS No.:467218-16-2
Molecular Formula:C₄₂H₅₀N₄O₆S₂
Molecular Weight:771.014
Hs Code.:

Synonyms:1,1'-(butane-1,4-diyl)bis[hexahydro-4-phenyl-5-tosyl-1,5-diazocin-2(1H)-one]

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Chemical Property of 1,1'-(butane-1,4-diyl)bis[hexahydro-4-phenyl-5-tosyl-1,5-diazocin-2(1H)-one]

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Technology Process of 1,1'-(butane-1,4-diyl)bis[hexahydro-4-phenyl-5-tosyl-1,5-diazocin-2(1H)-one]

There total 7 articles about 1,1'-(butane-1,4-diyl)bis[hexahydro-4-phenyl-5-tosyl-1,5-diazocin-2(1H)-one] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 110-52-1
1,4-dibromo-butane

: 467218-04-8
hexahydro-4-phenyl-5-tosyl-1,5-diazocin-2(1H)-one

: 467218-16-2
1,1'-(butane-1,4-diyl)bis[hexahydro-4-phenyl-5-tosyl-1,5-diazocin-2(1H)-one]

Guidance literature:: With potassium hydroxide; In dimethyl sulfoxide; at 0 - 20 ℃;
DOI:10.1002/1522-2675(200206)85:6<1659::AID-HLCA1659>3.0.CO;2-D

Reference yield:

: 3646-50-2
3-Amino-3-phenylpropionic acid

: 467218-16-2
1,1'-(butane-1,4-diyl)bis[hexahydro-4-phenyl-5-tosyl-1,5-diazocin-2(1H)-one]

Guidance literature:: Multi-step reaction with 6 steps

1: aq. NaOH / diethyl ether / 20 °C

2: SOCl₂ / 2.5 h / 0 - 20 °C

3: 80 percent / Cs₂CO₃ / dimethylformamide / 55 °C

4: 99 percent / CF₃COOH / CHCl₃ / 40 °C

5: 83 percent / Sb(OEt)3 / benzene / 16 h / Heating

6: 53 percent / KOH / dimethylsulfoxide / 0 - 20 °C

With potassium hydroxide; sodium hydroxide; thionyl chloride; triethoxyantimony; caesium carbonate; trifluoroacetic acid; In diethyl ether; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene;
DOI:10.1002/1522-2675(200206)85:6<1659::AID-HLCA1659>3.0.CO;2-D

Reference yield:

: 101719-48-6
ethyl 3-(4-methylphenylsulfonamido)-3-phenylpropanoate

: 467218-16-2
1,1'-(butane-1,4-diyl)bis[hexahydro-4-phenyl-5-tosyl-1,5-diazocin-2(1H)-one]

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / Cs₂CO₃ / dimethylformamide / 55 °C

2: 99 percent / CF₃COOH / CHCl₃ / 40 °C

3: 83 percent / Sb(OEt)3 / benzene / 16 h / Heating

4: 53 percent / KOH / dimethylsulfoxide / 0 - 20 °C

With potassium hydroxide; triethoxyantimony; caesium carbonate; trifluoroacetic acid; In chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene;
DOI:10.1002/1522-2675(200206)85:6<1659::AID-HLCA1659>3.0.CO;2-D