1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonyl chloride

Base Information

Chemical Name:1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonyl chloride
CAS No.:1255650-28-2
Molecular Formula:C₁₅H₁₆ClF₃N₂O₄S
Molecular Weight:412.817
Hs Code.:

Synonyms:1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonyl chloride

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Chemical Property of 1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonyl chloride

Chemical Property:

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Technology Process of 1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonyl chloride

There total 5 articles about 1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7791-25-5
sulfuryl dichloride

: 1255650-21-5
2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

: 1255650-28-2
1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonyl chloride

Guidance literature:: With triethylamine; In chloroform; at 0 - 20 ℃;

Reference yield:

: 461-82-5
4-(trifluoromethoxy)aniline

: 1255650-28-2
1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: dimethylaluminum chloride / hexane; toluene / 20 °C / Inert atmosphere; Reflux

1.2: 20 °C

2.1: triethylamine / chloroform / 0 - 20 °C

With dimethylaluminum chloride; triethylamine; In hexane; chloroform; toluene;

Reference yield:

: 1255650-19-1
1-benzyl-4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

: 1255650-28-2
1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonyl chloride

Guidance literature:: Multi-step reaction with 4 steps

1: dimethylaluminum chloride / n-heptane; toluene / 20 °C / Inert atmosphere; Reflux

2: hydrogen / 20% palladium hydroxide-activated charcoal / methanol / 3 h / 20 °C

3: sodium hydroxide / water

4: triethylamine / chloroform / 0 - 20 °C

With hydrogen; dimethylaluminum chloride; triethylamine; sodium hydroxide; 20% palladium hydroxide-activated charcoal; In methanol; n-heptane; chloroform; water; toluene;