1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonic acid isopropylamide

Base Information

Chemical Name:1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonic acid isopropylamide
CAS No.:1255715-00-4
Molecular Formula:C₁₈H₂₄F₃N₃O₄S
Molecular Weight:435.467
Hs Code.:

Synonyms:1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonic acid isopropylamide

Suppliers and Price of 1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonic acid isopropylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonic acid isopropylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonic acid isopropylamide

There total 6 articles about 1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonic acid isopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1255650-28-2
1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonyl chloride

: 75-31-0
isopropylamine

: 1255715-00-4
1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonic acid isopropylamide

Guidance literature:: With triethylamine; In dichloromethane; at 50 ℃; for 16h;

Reference yield:

: 461-82-5
4-(trifluoromethoxy)aniline

: 1255715-00-4
1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonic acid isopropylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethylaluminum chloride / hexane; toluene / 20 °C / Inert atmosphere; Reflux

1.2: 20 °C

2.1: triethylamine / chloroform / 0 - 20 °C

3.1: triethylamine / dichloromethane / 16 h / 50 °C

With dimethylaluminum chloride; triethylamine; In hexane; dichloromethane; chloroform; toluene;

Reference yield:

: 1255650-19-1
1-benzyl-4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

: 1255715-00-4
1-oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonic acid isopropylamide

Guidance literature:: Multi-step reaction with 5 steps

1: dimethylaluminum chloride / n-heptane; toluene / 20 °C / Inert atmosphere; Reflux

2: hydrogen / 20% palladium hydroxide-activated charcoal / methanol / 3 h / 20 °C

3: sodium hydroxide / water

4: triethylamine / chloroform / 0 - 20 °C

5: triethylamine / dichloromethane / 16 h / 50 °C

With hydrogen; dimethylaluminum chloride; triethylamine; sodium hydroxide; 20% palladium hydroxide-activated charcoal; In methanol; n-heptane; dichloromethane; chloroform; water; toluene;