[(S)-2-(4-Benzyloxy-phenyl)-1-((S)-1-{(S)-3-carbamoyl-1-[(S)-1-((S)-1-hydrazinocarbonyl-3-methyl-butylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-propylcarbamoyl}-3-methyl-butylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[(S)-2-(4-Benzyloxy-phenyl)-1-((S)-1-{(S)-3-carbamoyl-1-[(S)-1-((S)-1-hydrazinocarbonyl-3-methyl-butylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-propylcarbamoyl}-3-methyl-butylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester
CAS No.:119155-08-7
Molecular Formula:C₄₄H₆₄N₁₀O₉
Molecular Weight:877.054
Hs Code.:

[(S)-2-(4-Benzyloxy-phenyl)-1-((S)-1-{(S)-3-carbamoyl-1-[(S)-1-((S)-1-hydrazinocarbonyl-3-methyl-butylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-propylcarbamoyl}-3-methyl-butylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

Synonyms:[(S)-2-(4-Benzyloxy-phenyl)-1-((S)-1-{(S)-3-carbamoyl-1-[(S)-1-((S)-1-hydrazinocarbonyl-3-methyl-butylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-propylcarbamoyl}-3-methyl-butylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

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Chemical Property of [(S)-2-(4-Benzyloxy-phenyl)-1-((S)-1-{(S)-3-carbamoyl-1-[(S)-1-((S)-1-hydrazinocarbonyl-3-methyl-butylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-propylcarbamoyl}-3-methyl-butylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

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Technology Process of [(S)-2-(4-Benzyloxy-phenyl)-1-((S)-1-{(S)-3-carbamoyl-1-[(S)-1-((S)-1-hydrazinocarbonyl-3-methyl-butylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-propylcarbamoyl}-3-methyl-butylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

There total 6 articles about [(S)-2-(4-Benzyloxy-phenyl)-1-((S)-1-{(S)-3-carbamoyl-1-[(S)-1-((S)-1-hydrazinocarbonyl-3-methyl-butylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-propylcarbamoyl}-3-methyl-butylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 119155-17-8
(S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-3-(4-Benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-4-methyl-pentanoylamino}-4-carbamoyl-butyrylamino)-3-(1H-imidazol-4-yl)-propionylamino]-4-methyl-pentanoic acid methyl ester

: 119155-08-7
[(S)-2-(4-Benzyloxy-phenyl)-1-((S)-1-{(S)-3-carbamoyl-1-[(S)-1-((S)-1-hydrazinocarbonyl-3-methyl-butylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-propylcarbamoyl}-3-methyl-butylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: With hydrazine hydrate; In methanol; N,N-dimethyl-formamide; for 24h; Ambient temperature;
DOI:10.1248/cpb.36.2506

Reference yield:

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 119155-08-7
[(S)-2-(4-Benzyloxy-phenyl)-1-((S)-1-{(S)-3-carbamoyl-1-[(S)-1-((S)-1-hydrazinocarbonyl-3-methyl-butylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-propylcarbamoyl}-3-methyl-butylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / N-methylmorpholine / dimethylformamide / 5 h / Ambient temperature

2: 1.) TFA, anisole; 2.) N-methylmorpholine / 1.) 40 min; 2.) DMF, room temperature, 8 h

3: 1.) TFA, anisole; 2.) N-methylmorpholine / 1.) 40 min; 2.) DMF, room temperature, 5 h

4: 1.) TFA, anisole; 2.) N-methylmorpholine / 1.) 40 min; 2.) DMF, room temperature, 5 h

5: 91 percent / hydrazine hydrate / dimethylformamide; methanol / 24 h / Ambient temperature

With 4-methyl-morpholine; hydrazine hydrate; methoxybenzene; trifluoroacetic acid; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.36.2506

Reference yield:

: 119155-36-1
(S)-2-tert-Butoxycarbonylamino-3-(1H-imidazol-4-yl)-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

: 119155-08-7
[(S)-2-(4-Benzyloxy-phenyl)-1-((S)-1-{(S)-3-carbamoyl-1-[(S)-1-((S)-1-hydrazinocarbonyl-3-methyl-butylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-propylcarbamoyl}-3-methyl-butylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / N-methylmorpholine / dimethylformamide / 5 h / Ambient temperature

2: 1.) TFA, anisole; 2.) N-methylmorpholine / 1.) 40 min; 2.) DMF, room temperature, 8 h

3: 1.) TFA, anisole; 2.) N-methylmorpholine / 1.) 40 min; 2.) DMF, room temperature, 5 h

4: 1.) TFA, anisole; 2.) N-methylmorpholine / 1.) 40 min; 2.) DMF, room temperature, 5 h

5: 91 percent / hydrazine hydrate / dimethylformamide; methanol / 24 h / Ambient temperature

With 4-methyl-morpholine; hydrazine hydrate; methoxybenzene; trifluoroacetic acid; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.36.2506