(S)-2-tert-Butoxycarbonylamino-3-(1H-imidazol-4-yl)-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

Base Information

Chemical Name:(S)-2-tert-Butoxycarbonylamino-3-(1H-imidazol-4-yl)-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester
CAS No.:119155-36-1
Molecular Formula:C₁₅H₂₀N₄O₆
Molecular Weight:352.347
Hs Code.:

Synonyms:(S)-2-tert-Butoxycarbonylamino-3-(1H-imidazol-4-yl)-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

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Chemical Property of (S)-2-tert-Butoxycarbonylamino-3-(1H-imidazol-4-yl)-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

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Technology Process of (S)-2-tert-Butoxycarbonylamino-3-(1H-imidazol-4-yl)-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

There total 1 articles about (S)-2-tert-Butoxycarbonylamino-3-(1H-imidazol-4-yl)-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 17791-52-5
N-(tert-butoxycarbonyl)-L-histidine

: 119155-36-1
(S)-2-tert-Butoxycarbonylamino-3-(1H-imidazol-4-yl)-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃; for 2h;
DOI:10.1039/c5ob00157a

Reference yield:

: 119155-36-1
(S)-2-tert-Butoxycarbonylamino-3-(1H-imidazol-4-yl)-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

: 119155-08-7
[(S)-2-(4-Benzyloxy-phenyl)-1-((S)-1-{(S)-3-carbamoyl-1-[(S)-1-((S)-1-hydrazinocarbonyl-3-methyl-butylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-propylcarbamoyl}-3-methyl-butylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / N-methylmorpholine / dimethylformamide / 5 h / Ambient temperature

2: 1.) TFA, anisole; 2.) N-methylmorpholine / 1.) 40 min; 2.) DMF, room temperature, 8 h

3: 1.) TFA, anisole; 2.) N-methylmorpholine / 1.) 40 min; 2.) DMF, room temperature, 5 h

4: 1.) TFA, anisole; 2.) N-methylmorpholine / 1.) 40 min; 2.) DMF, room temperature, 5 h

5: 91 percent / hydrazine hydrate / dimethylformamide; methanol / 24 h / Ambient temperature

With 4-methyl-morpholine; hydrazine hydrate; methoxybenzene; trifluoroacetic acid; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.36.2506

Reference yield:

: 119155-36-1
(S)-2-tert-Butoxycarbonylamino-3-(1H-imidazol-4-yl)-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

: 119155-17-8
(S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-3-(4-Benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-4-methyl-pentanoylamino}-4-carbamoyl-butyrylamino)-3-(1H-imidazol-4-yl)-propionylamino]-4-methyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / N-methylmorpholine / dimethylformamide / 5 h / Ambient temperature

2: 1.) TFA, anisole; 2.) N-methylmorpholine / 1.) 40 min; 2.) DMF, room temperature, 8 h

3: 1.) TFA, anisole; 2.) N-methylmorpholine / 1.) 40 min; 2.) DMF, room temperature, 5 h

4: 1.) TFA, anisole; 2.) N-methylmorpholine / 1.) 40 min; 2.) DMF, room temperature, 5 h

With 4-methyl-morpholine; methoxybenzene; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.36.2506