3-(3,5-bis(trifluoromethyl)phenylamino)-4-((3R,5S)-5-((tertbutyldiphenylsilyloxy)methyl)pyrrolidin-3-ylamino)cyclobut-3-ene-1,2-dione

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Chemical Name:3-(3,5-bis(trifluoromethyl)phenylamino)-4-((3R,5S)-5-((tertbutyldiphenylsilyloxy)methyl)pyrrolidin-3-ylamino)cyclobut-3-ene-1,2-dione
CAS No.:1372972-00-3
Molecular Formula:C₃₃H₃₃F₆N₃O₃Si
Molecular Weight:661.719
Hs Code.:

Synonyms:3-(3,5-bis(trifluoromethyl)phenylamino)-4-((3R,5S)-5-((tertbutyldiphenylsilyloxy)methyl)pyrrolidin-3-ylamino)cyclobut-3-ene-1,2-dione

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Chemical Property of 3-(3,5-bis(trifluoromethyl)phenylamino)-4-((3R,5S)-5-((tertbutyldiphenylsilyloxy)methyl)pyrrolidin-3-ylamino)cyclobut-3-ene-1,2-dione

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Technology Process of 3-(3,5-bis(trifluoromethyl)phenylamino)-4-((3R,5S)-5-((tertbutyldiphenylsilyloxy)methyl)pyrrolidin-3-ylamino)cyclobut-3-ene-1,2-dione

There total 8 articles about 3-(3,5-bis(trifluoromethyl)phenylamino)-4-((3R,5S)-5-((tertbutyldiphenylsilyloxy)methyl)pyrrolidin-3-ylamino)cyclobut-3-ene-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1372972-21-8
C₃₈H₄₁F₆N₃O₅Si

: 1372972-00-3
3-(3,5-bis(trifluoromethyl)phenylamino)-4-((3R,5S)-5-((tertbutyldiphenylsilyloxy)methyl)pyrrolidin-3-ylamino)cyclobut-3-ene-1,2-dione

Guidance literature:: C₃₈H₄₁F₆N₃O₅Si; With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 6h;

With ammonia; In water; pH=8;
DOI:10.1039/c2ob00049k

Reference yield:

: 1159114-52-9
tert-butyl (2S,4R)-4-azido-2-(((tert-butyldiphenylsilyl)oxy)methyl)pyrrolidine-1-carboxylate

: 1372972-00-3
3-(3,5-bis(trifluoromethyl)phenylamino)-4-((3R,5S)-5-((tertbutyldiphenylsilyloxy)methyl)pyrrolidin-3-ylamino)cyclobut-3-ene-1,2-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine / water

2.1: methanol / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 6 h / 0 °C

3.2: pH 8

With triphenylphosphine; trifluoroacetic acid; In methanol; dichloromethane; water;
DOI:10.1039/c2ob00049k

Reference yield:

: 74844-91-0,114676-69-6,135042-17-0,227935-38-8,102195-79-9
(2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester

: 1372972-00-3
3-(3,5-bis(trifluoromethyl)phenylamino)-4-((3R,5S)-5-((tertbutyldiphenylsilyloxy)methyl)pyrrolidin-3-ylamino)cyclobut-3-ene-1,2-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol

3.1: 1H-imidazole / dichloromethane

4.1: sodium azide / N,N-dimethyl-formamide

5.1: triphenylphosphine / water

6.1: methanol / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 6 h / 0 °C

7.2: pH 8

With 1H-imidazole; sodium tetrahydroborate; sodium azide; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c2ob00049k