4-(4-Fluoro-alpha-methoxybenzyl)piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(4-Fluoro-alpha-methoxybenzyl)piperidine-1-carboxylic acid tert-butyl ester
CAS No.:160296-42-4
Molecular Formula:C₁₈H₂₆FNO₃
Molecular Weight:323.408
Hs Code.:
Nikkaji Number:J747.931J

Synonyms:SCHEMBL7417677;4-(4-Fluoro-alpha-methoxybenzyl)piperidine-1-carboxylic acid tert-butyl ester

Suppliers and Price of 4-(4-Fluoro-alpha-methoxybenzyl)piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-(4-Fluoro-alpha-methoxybenzyl)piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:323.18967185
Heavy Atom Count:23
Complexity:380

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)C(C2=CC=C(C=C2)F)OC

Technology Process of 4-(4-Fluoro-alpha-methoxybenzyl)piperidine-1-carboxylic acid tert-butyl ester

There total 5 articles about 4-(4-Fluoro-alpha-methoxybenzyl)piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 160296-41-3
4-[(4-fluorophenyl)hydroxymethyl]piperidine-1-carboxylic acid tert-butyl ester

: 74-88-4
methyl iodide

: 160296-42-4
tert-butyl 4-((4-fluorophenyl)(methoxy)methyl)piperidine-1-carboxylate

Guidance literature:: 4-[(4-fluorophenyl)hydroxymethyl]piperidine-1-carboxylic acid tert-butyl ester; With sodium hydride; In tetrahydrofuran; for 0.5h;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 56346-57-7
(4-fluorophenyl)-piperidin-4-ylmethanone

: 160296-42-4
tert-butyl 4-((4-fluorophenyl)(methoxy)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / Et₃N / tetrahydrofuran / Ambient temperature

2: 59 percent / NaBH₄ / ethanol / 2 h / Ambient temperature

3: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, RT, 16 h

With sodium tetrahydroborate; sodium hydride; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1021/jm950894b

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 160296-42-4
tert-butyl 4-((4-fluorophenyl)(methoxy)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / Et₃N / tetrahydrofuran / Ambient temperature

2: 59 percent / NaBH₄ / ethanol / 2 h / Ambient temperature

3: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, RT, 16 h

With sodium tetrahydroborate; sodium hydride; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1021/jm950894b