(2R,4R)-4-(aminomethyl)-2-[(1H-imidazol-1-yl)methyl]-2-[(2-phenyl)ethyl]-1,3-dioxolane

Base Information

Chemical Name:(2R,4R)-4-(aminomethyl)-2-[(1H-imidazol-1-yl)methyl]-2-[(2-phenyl)ethyl]-1,3-dioxolane
CAS No.:1093058-50-4
Molecular Formula:C₁₆H₂₁N₃O₂
Molecular Weight:287.362
Hs Code.:

Synonyms:(2R,4R)-4-(aminomethyl)-2-[(1H-imidazol-1-yl)methyl]-2-[(2-phenyl)ethyl]-1,3-dioxolane

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Chemical Property of (2R,4R)-4-(aminomethyl)-2-[(1H-imidazol-1-yl)methyl]-2-[(2-phenyl)ethyl]-1,3-dioxolane

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Technology Process of (2R,4R)-4-(aminomethyl)-2-[(1H-imidazol-1-yl)methyl]-2-[(2-phenyl)ethyl]-1,3-dioxolane

There total 4 articles about (2R,4R)-4-(aminomethyl)-2-[(1H-imidazol-1-yl)methyl]-2-[(2-phenyl)ethyl]-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093058-31-1
(2R,4R)-4-(azidomethyl)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane

: 1093058-50-4
(2R,4R)-4-(aminomethyl)-2-[(1H-imidazol-1-yl)methyl]-2-[(2-phenyl)ethyl]-1,3-dioxolane

Guidance literature:: With palladium 10% on activated carbon; ammonium formate; In methanol; N,N-dimethyl-formamide; for 3h; Reflux;
DOI:10.1016/j.bmc.2009.01.078

Reference yield:

: 67085-11-4
1-[2-hydroxy-4-(4-chlorophenyl)-n-butyl]imidazole

: 1093058-50-4
(2R,4R)-4-(aminomethyl)-2-[(1H-imidazol-1-yl)methyl]-2-[(2-phenyl)ethyl]-1,3-dioxolane

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride; dimethyl sulfoxide; triethylamine

2: toluene-4-sulfonic acid / toluene; butan-1-ol / 8 h / Heating / reflux

3: sodium azide / N,N-dimethyl-formamide / 2 h / 110 °C

4: ammonium formate / palladium 10% on activated carbon / methanol / 3 h / Heating / reflux

With sodium azide; oxalyl dichloride; ammonium formate; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide; toluene; butan-1-ol; 1: Swern Oxidation;

Reference yield:

: 82362-50-3
4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanone

: 1093058-50-4
(2R,4R)-4-(aminomethyl)-2-[(1H-imidazol-1-yl)methyl]-2-[(2-phenyl)ethyl]-1,3-dioxolane

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / toluene; butan-1-ol / 8 h / Heating / reflux

2: sodium azide / N,N-dimethyl-formamide / 2 h / 110 °C

3: ammonium formate / palladium 10% on activated carbon / methanol / 3 h / Heating / reflux

With sodium azide; ammonium formate; toluene-4-sulfonic acid; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide; toluene; butan-1-ol;