4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol

Base Information

Chemical Name:4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol
CAS No.:67085-11-4
Molecular Formula:C13H15 Cl N2 O
Molecular Weight:250.728
Hs Code.:2933290090
European Community (EC) Number:925-590-5,614-017-1
DSSTox Substance ID:DTXSID80449756
ChEMBL ID:CHEMBL581735
Mol file:67085-11-4.mol

Synonyms:4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol;QC-10 compound

Suppliers and Price of 4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol
25g
$ 123.00

Alichem
4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol
25g
$ 185.40

Ambeed
4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol 98%
25g
$ 50.00

Ambeed
4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol 98%
1g
$ 6.00

Ambeed
4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol 98%
5g
$ 15.00

American Custom Chemicals Corporation
1-[4-(4-CHLOROPHENYL)-2-HYDROXYLBUTYL]IMIDAZOLE 95.00%
5MG
$ 503.64

Biosynth Carbosynth
1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole
1 g
$ 582.00

Biosynth Carbosynth
1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole
250 mg
$ 192.50

Biosynth Carbosynth
1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole
500 mg
$ 335.00

Biosynth Carbosynth
1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole
100 mg
$ 97.00

Total 59 raw suppliers

Chemical Property of 4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:106-109 °C(Solv: ethyl acetate (141-78-6))
Refractive Index:1.59
Boiling Point:472.169 °C at 760 mmHg
PKA:13.69±0.20(Predicted)
Flash Point:239.36 °C
PSA：38.05000
Density:1.211 g/cm³
LogP:2.53020
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:Chloroform (Slightly), DMSO, Methanol (Slightly)
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:250.0872908
Heavy Atom Count:17
Complexity:220

Purity/Quality:

99% ^*data from raw suppliers

4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1CCC(CN2C=CN=C2)O)Cl
Uses α-[2-(4-Chlorophenyl)ethyl]-1H-imidazole-1-ethanol is used as a reactant in the preparation of imidazol phenylbutane derivatives as heme oxygenase inhibitors. α-[2-(4-Chlorophenyl)ethyl]-1H-imidazole-1-ethanol is also an impurity of Butoconazole (B690273), which is an antifungal.

Technology Process of 4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol

There total 3 articles about 4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.31%

: 288-32-4
1H-imidazole

: 59363-13-2
1-chloro-4-(4-chlorophenyl)-2-butanol

: 67085-11-4
1-[2-hydroxy-4-(4-chlorophenyl)-n-butyl]imidazole

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 58 - 62 ℃; for 3h; Temperature; Time; Cooling with ice;

Reference yield:

: 104-83-6
1-Chloro-4-(chloromethyl)benzene

: 67085-11-4
1-[2-hydroxy-4-(4-chlorophenyl)-n-butyl]imidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium; iodine / diethyl ether / 0.25 h / Heating

1.2: 57 percent / diethyl ether / 2 h / Heating

2.1: sodium hydride / dimethylformamide / 4.5 h / 70 - 80 °C

With iodine; sodium hydride; magnesium; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2007.02.034