4-(2,4,6-trimethylphenyl)-2-[(4,5-dihydro-5-thioxo-1,3,4-oxadiazol-2-yl)methyl]phthalazin-1(2H)-one

Base Information

Chemical Name:4-(2,4,6-trimethylphenyl)-2-[(4,5-dihydro-5-thioxo-1,3,4-oxadiazol-2-yl)methyl]phthalazin-1(2H)-one
CAS No.:1374218-15-1
Molecular Formula:C₂₀H₁₈N₄O₂S
Molecular Weight:378.455
Hs Code.:

Synonyms:4-(2,4,6-trimethylphenyl)-2-[(4,5-dihydro-5-thioxo-1,3,4-oxadiazol-2-yl)methyl]phthalazin-1(2H)-one

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Chemical Property of 4-(2,4,6-trimethylphenyl)-2-[(4,5-dihydro-5-thioxo-1,3,4-oxadiazol-2-yl)methyl]phthalazin-1(2H)-one

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Technology Process of 4-(2,4,6-trimethylphenyl)-2-[(4,5-dihydro-5-thioxo-1,3,4-oxadiazol-2-yl)methyl]phthalazin-1(2H)-one

There total 6 articles about 4-(2,4,6-trimethylphenyl)-2-[(4,5-dihydro-5-thioxo-1,3,4-oxadiazol-2-yl)methyl]phthalazin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 75-15-0,12122-00-8
carbon disulfide

: 1374218-14-0
[4-(2,4,6-trimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid hydrazide

: 1374218-15-1
4-(2,4,6-trimethylphenyl)-2-[(4,5-dihydro-5-thioxo-1,3,4-oxadiazol-2-yl)methyl]phthalazin-1(2H)-one

Guidance literature:: With potassium hydroxide; In ethanol; for 18h; Reflux;
DOI:10.1002/cjoc.201100256

Reference yield:

: 85-44-9
phthalic anhydride

: 1374218-15-1
4-(2,4,6-trimethylphenyl)-2-[(4,5-dihydro-5-thioxo-1,3,4-oxadiazol-2-yl)methyl]phthalazin-1(2H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: aluminum (III) chloride

2: hydrazine hydrate / ethanol / 2 h / Reflux

3: potassium carbonate / acetone / 30 h / Reflux

4: hydrazine hydrate / ethanol / 2 h / Reflux

5: potassium hydroxide / ethanol / 18 h / Reflux

With aluminum (III) chloride; potassium carbonate; hydrazine hydrate; potassium hydroxide; In ethanol; acetone; 1: Friedel Crafts reaction;
DOI:10.1002/cjoc.201100256

Reference yield:

: 1374218-13-9
[4-(2,4,6-trimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid ethyl ester

: 1374218-15-1
4-(2,4,6-trimethylphenyl)-2-[(4,5-dihydro-5-thioxo-1,3,4-oxadiazol-2-yl)methyl]phthalazin-1(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 2 h / Reflux

2: potassium hydroxide / ethanol / 18 h / Reflux

With hydrazine hydrate; potassium hydroxide; In ethanol;
DOI:10.1002/cjoc.201100256