[4-(2,4,6-trimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid hydrazide

Base Information

• Chemical Name: [4-(2,4,6-trimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid hydrazide
• CAS No.: 1374218-14-0
• Molecular Formula: C₁₉H₂₀N₄O₂
• Molecular Weight: 336.393

Synonyms:[4-(2,4,6-trimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid hydrazide

Chemical Property of [4-(2,4,6-trimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid hydrazide

Chemical Property:

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Technology Process of [4-(2,4,6-trimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid hydrazide

There total 5 articles about [4-(2,4,6-trimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

[4-(2,4,6-trimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid ethyl ester (1374218-13-9) → [4-(2,4,6-trimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid hydrazide (1374218-14-0)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Reflux;

DOI:10.1002/cjoc.201100256

Reference yield:

4-(2,4,6-trimethylphenyl)-2,3-phthalazin-1-one (209416-34-2) → [4-(2,4,6-trimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid hydrazide (1374218-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 30 h / Reflux

2: hydrazine hydrate / ethanol / 2 h / Reflux

With potassium carbonate; hydrazine hydrate; In ethanol; acetone;

DOI:10.1002/cjoc.201100256

Reference yield:

phthalic anhydride (85-44-9) → [4-(2,4,6-trimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid hydrazide (1374218-14-0)

Guidance literature:

Multi-step reaction with 4 steps

1: aluminum (III) chloride

2: hydrazine hydrate / ethanol / 2 h / Reflux

3: potassium carbonate / acetone / 30 h / Reflux

4: hydrazine hydrate / ethanol / 2 h / Reflux

With aluminum (III) chloride; potassium carbonate; hydrazine hydrate; In ethanol; acetone; 1: Friedel Crafts reaction;

DOI:10.1002/cjoc.201100256

upstream raw materials:

phthalic anhydride

[4-(2,4,6-trimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid ethyl ester

4-(2,4,6-trimethylphenyl)-2,3-phthalazin-1-one

2-(2,4,6-trimethylbenzoyl)-benzoic acid

Downstream raw materials:

N'-(furan-2-ylmethylene)-2-(4-mesityl-1-oxophthalazin-2(1H)-yl)acetohydrazide

2-(4-mesityl-1-oxophthalazin-2(1H)-yl)-N'-(thiophen-2-ylmethylene)acetohydrazide

4-(2,4,6-trimethylphenyl)-2-[(4,5-dihydro-5-thioxo-1,3,4-oxadiazol-2-yl)methyl]phthalazin-1(2H)-one

N'-(1,3-dioxoisoindolin-2-yl)-2-(4-mesityl-1-oxophthalazin-2(1H)-yl)acetamide

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