phenylmethyl 5-(6,8-diaza-7-oxo-6-(2-phosphonoacetyl)-3-thiabicyclo[3.3.0]oct-2-yl)pentanoate

Base Information

Chemical Name:phenylmethyl 5-(6,8-diaza-7-oxo-6-(2-phosphonoacetyl)-3-thiabicyclo[3.3.0]oct-2-yl)pentanoate
CAS No.:236749-60-3
Molecular Formula:C₁₉H₂₅N₂O₇PS
Molecular Weight:456.456
Hs Code.:

Synonyms:phenylmethyl 5-(6,8-diaza-7-oxo-6-(2-phosphonoacetyl)-3-thiabicyclo[3.3.0]oct-2-yl)pentanoate

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Chemical Property of phenylmethyl 5-(6,8-diaza-7-oxo-6-(2-phosphonoacetyl)-3-thiabicyclo[3.3.0]oct-2-yl)pentanoate

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Technology Process of phenylmethyl 5-(6,8-diaza-7-oxo-6-(2-phosphonoacetyl)-3-thiabicyclo[3.3.0]oct-2-yl)pentanoate

There total 5 articles about phenylmethyl 5-(6,8-diaza-7-oxo-6-(2-phosphonoacetyl)-3-thiabicyclo[3.3.0]oct-2-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 235429-57-9
phenylmethyl 5-(6,8-diaza-6-(2-diethoxyphosphonoacetyl)-7-oxo-3-thiabicyclo[3.3.0]oct-2-yl)pentanoate

: 236749-60-3
phenylmethyl 5-(6,8-diaza-7-oxo-6-(2-phosphonoacetyl)-3-thiabicyclo[3.3.0]oct-2-yl)pentanoate

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/ol990026z

Reference yield:

: 100023-76-5
phenylmethyl 5-(6,8-diaza-7-oxo-3-thiabicyclo[3.3.0]oct-2-yl)pentanoate

: 236749-60-3
phenylmethyl 5-(6,8-diaza-7-oxo-6-(2-phosphonoacetyl)-3-thiabicyclo[3.3.0]oct-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / Et₃N / CH₂Cl₂ / 12 h / -78 °C

2: 89 percent / 3 h / 100 °C

3: 72 percent / TMSBr / CH₂Cl₂ / 2 h / 20 °C

With trimethylsilyl bromide; triethylamine; In dichloromethane; 2: Arbuzov reaction;
DOI:10.1021/ol990026z

Reference yield:

: 235429-56-8
phenylmethyl 5-(6,8-diaza-6-(2-chloroacetyl)-7-oxo-3-thiabicyclo[3.3.0]oct-2-yl)pentanoate

: 236749-60-3
phenylmethyl 5-(6,8-diaza-7-oxo-6-(2-phosphonoacetyl)-3-thiabicyclo[3.3.0]oct-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / 3 h / 100 °C

2: 72 percent / TMSBr / CH₂Cl₂ / 2 h / 20 °C

With trimethylsilyl bromide; In dichloromethane; 1: Arbuzov reaction;
DOI:10.1021/ol990026z