phenylmethyl 5-(6,8-diaza-6-(2-chloroacetyl)-7-oxo-3-thiabicyclo[3.3.0]oct-2-yl)pentanoate

Base Information

Chemical Name:phenylmethyl 5-(6,8-diaza-6-(2-chloroacetyl)-7-oxo-3-thiabicyclo[3.3.0]oct-2-yl)pentanoate
CAS No.:235429-56-8
Molecular Formula:C₁₉H₂₃ClN₂O₄S
Molecular Weight:410.922
Hs Code.:

Synonyms:phenylmethyl 5-(6,8-diaza-6-(2-chloroacetyl)-7-oxo-3-thiabicyclo[3.3.0]oct-2-yl)pentanoate

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Chemical Property of phenylmethyl 5-(6,8-diaza-6-(2-chloroacetyl)-7-oxo-3-thiabicyclo[3.3.0]oct-2-yl)pentanoate

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Technology Process of phenylmethyl 5-(6,8-diaza-6-(2-chloroacetyl)-7-oxo-3-thiabicyclo[3.3.0]oct-2-yl)pentanoate

There total 3 articles about phenylmethyl 5-(6,8-diaza-6-(2-chloroacetyl)-7-oxo-3-thiabicyclo[3.3.0]oct-2-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 100023-76-5
phenylmethyl 5-(6,8-diaza-7-oxo-3-thiabicyclo[3.3.0]oct-2-yl)pentanoate

: 79-04-9
chloroacetyl chloride

: 235429-56-8
phenylmethyl 5-(6,8-diaza-6-(2-chloroacetyl)-7-oxo-3-thiabicyclo[3.3.0]oct-2-yl)pentanoate

Guidance literature:: With triethylamine; In dichloromethane; at -78 ℃; for 12h;
DOI:10.1021/ol990026z

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 235429-56-8
phenylmethyl 5-(6,8-diaza-6-(2-chloroacetyl)-7-oxo-3-thiabicyclo[3.3.0]oct-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / DMAP; HOBt; DCC / dimethylformamide / 12 h / 20 °C

2: 98 percent / Et₃N / CH₂Cl₂ / 12 h / -78 °C

With dmap; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol990026z

Reference yield:

: 58-85-5,22879-79-4
biotin

: 235429-56-8
phenylmethyl 5-(6,8-diaza-6-(2-chloroacetyl)-7-oxo-3-thiabicyclo[3.3.0]oct-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / DMAP; HOBt; DCC / dimethylformamide / 12 h / 20 °C

2: 98 percent / Et₃N / CH₂Cl₂ / 12 h / -78 °C

With dmap; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol990026z