N-(5-{3-[(2-bromo-6-hydroxybenzyl)amino]phenyl}-4-methyl-1,3-thiazol-2-yl)guanidine

Base Information

Chemical Name:N-(5-{3-[(2-bromo-6-hydroxybenzyl)amino]phenyl}-4-methyl-1,3-thiazol-2-yl)guanidine
CAS No.:952750-62-8
Molecular Formula:C₁₈H₁₈BrN₅OS
Molecular Weight:432.344
Hs Code.:

Synonyms:N-(5-{3-[(2-bromo-6-hydroxybenzyl)amino]phenyl}-4-methyl-1,3-thiazol-2-yl)guanidine

Suppliers and Price of N-(5-{3-[(2-bromo-6-hydroxybenzyl)amino]phenyl}-4-methyl-1,3-thiazol-2-yl)guanidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of N-(5-{3-[(2-bromo-6-hydroxybenzyl)amino]phenyl}-4-methyl-1,3-thiazol-2-yl)guanidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(5-{3-[(2-bromo-6-hydroxybenzyl)amino]phenyl}-4-methyl-1,3-thiazol-2-yl)guanidine

There total 4 articles about N-(5-{3-[(2-bromo-6-hydroxybenzyl)amino]phenyl}-4-methyl-1,3-thiazol-2-yl)guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 952751-29-0
N-[5-(4-aminophenyl)-4-ethyl-1,3-thiazol-2-yl]guanidine

: 22532-61-2
2-bromo-6-hydroxybenzaldehyde

: 952750-62-8
N-(5-{3-[(2-bromo-6-hydroxybenzyl)amino]phenyl}-4-methyl-1,3-thiazol-2-yl)guanidine

Guidance literature:: With polymer-bound trimethyl ammonium cyanoborohydride; acetic acid; In dichloromethane; at 20 ℃; for 3h; Polystyrene

Reference yield:

: 1159681-86-3
2-ethyl-2-nitro-3-(4-nitrophenyl)oxirane

: 952750-62-8
N-(5-{3-[(2-bromo-6-hydroxybenzyl)amino]phenyl}-4-methyl-1,3-thiazol-2-yl)guanidine

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 2 h / 90 °C

2: ammonium formate / palladium 10% on activated carbon / methanol / 0.08 h / 140 °C / Microwave irradiation

3: polymer-bound trimethyl ammonium cyanoborohydride; acetic acid / dichloromethane / 3 h / 20 °C

With polymer-bound trimethyl ammonium cyanoborohydride; ammonium formate; acetic acid; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane;

Reference yield:

: 952751-27-8
N-[4-ethyl-5-(4-nitrophenyl)-1,3-thiazol-2-yl]guanidine

: 952750-62-8
N-(5-{3-[(2-bromo-6-hydroxybenzyl)amino]phenyl}-4-methyl-1,3-thiazol-2-yl)guanidine

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium formate / palladium 10% on activated carbon / methanol / 0.08 h / 140 °C / Microwave irradiation

2: polymer-bound trimethyl ammonium cyanoborohydride; acetic acid / dichloromethane / 3 h / 20 °C

With polymer-bound trimethyl ammonium cyanoborohydride; ammonium formate; acetic acid; palladium 10% on activated carbon; In methanol; dichloromethane;