2-BROMO-6-HYDROXYBENZALDEHYDE

Base Information

Chemical Name:2-BROMO-6-HYDROXYBENZALDEHYDE
CAS No.:22532-61-2
Molecular Formula:C7H5BrO2
Molecular Weight:201.019
Hs Code.:2913000090
European Community (EC) Number:696-195-0
DSSTox Substance ID:DTXSID30474659
Nikkaji Number:J1.399.370J
Wikidata:Q72456798
Mol file:22532-61-2.mol

Synonyms:Salicylaldehyde,6-bromo- (8CI);6-Bromo-2-hydroxybenzaldehyde;6-Bromosalicylaldehyde;

Suppliers and Price of 2-BROMO-6-HYDROXYBENZALDEHYDE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Bromo-6-hydroxybenzaldehyde
5g
$ 70.00

SynQuest Laboratories
2-Bromo-6-hydroxybenzaldehyde
500 mg
$ 16.00

Medical Isotopes, Inc.
2-Bromo-6-hydroxybenzaldehyde
25 g
$ 1475.00

Medical Isotopes, Inc.
2-Bromo-6-hydroxybenzaldehyde
1 g
$ 625.00

Matrix Scientific
2-Bromo-6-hydroxybenzaldehyde 95+%
1g
$ 40.00

Matrix Scientific
2-Bromo-6-hydroxybenzaldehyde 95+%
5g
$ 145.00

Matrix Scientific
2-Bromo-6-hydroxybenzaldehyde 95+%
25g
$ 442.00

Crysdot
2-Bromo-6-hydroxybenzaldehyde 98%
100g
$ 446.00

CHESS?
KS000172:2-Bromo-6-hydroxy-benzaldehyde 95
5 g
$ 1068.00

CHESS?
KS000172:2-Bromo-6-hydroxy-benzaldehyde 95
1 g
$ 336.00

Total 75 raw suppliers

Chemical Property of 2-BROMO-6-HYDROXYBENZALDEHYDE

Chemical Property:

Melting Point:50-52 °C
Boiling Point:243.393 °C at 760 mmHg
PKA:7.21±0.10(Predicted)
Flash Point:101.001 °C
PSA：37.30000
Density:1.737 g/cm³
LogP:1.96720
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:199.94729
Heavy Atom Count:10
Complexity:127

Purity/Quality:

98% ^*data from raw suppliers

2-Bromo-6-hydroxybenzaldehyde ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C(=C1)Br)C=O)O
Uses 2-Bromo-6-hydroxybenzaldehyde, is a substituted salicylaldehyde used in the synthesis of BIIB042, a γ-secretase modulator.

Technology Process of 2-BROMO-6-HYDROXYBENZALDEHYDE

There total 15 articles about 2-BROMO-6-HYDROXYBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 126712-07-0
2-bromo-6-methoxybenzaldehyde

: 22532-61-2
2-bromo-6-hydroxybenzaldehyde

Guidance literature:: With boron tribromide; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/ja0568852

Reference yield: 70.0%

: 90-02-8
salicylaldehyde

: 22532-61-2
2-bromo-6-hydroxybenzaldehyde

: 1761-61-1
5-bromosalicyclaldehyde

Guidance literature:: With trimethylsilyl bromide; bis(4-chlorophenyl)sulfoxide; In acetonitrile; at 25 ℃; for 6h; regioselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201900794

Reference yield: 60.0%

: 863870-72-8
O-3-bromophenyl N,N-diethylcarbamate

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 22532-61-2
2-bromo-6-hydroxybenzaldehyde

Guidance literature:: O-3-bromophenyl N,N-diethylcarbamate; N,N-dimethyl-formamide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃; for 1.25h; Inert atmosphere;

With hydrogenchloride; In water; at 0 ℃; for 14h; Inert atmosphere;
DOI:10.1021/ol302691j