5-(2-methoxy-2-oxoethyl)-3-(1-(3-(trifluoromethyl)phenyl)-1H-indol-3-yl)-5-(1-methoxy-1-oxomethyl)-4,5-dihydroisoxazole

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Chemical Name:5-(2-methoxy-2-oxoethyl)-3-(1-(3-(trifluoromethyl)phenyl)-1H-indol-3-yl)-5-(1-methoxy-1-oxomethyl)-4,5-dihydroisoxazole
CAS No.:1283629-12-8
Molecular Formula:C₂₃H₁₉F₃N₂O₅
Molecular Weight:460.409
Hs Code.:

Synonyms:5-(2-methoxy-2-oxoethyl)-3-(1-(3-(trifluoromethyl)phenyl)-1H-indol-3-yl)-5-(1-methoxy-1-oxomethyl)-4,5-dihydroisoxazole

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Chemical Property of 5-(2-methoxy-2-oxoethyl)-3-(1-(3-(trifluoromethyl)phenyl)-1H-indol-3-yl)-5-(1-methoxy-1-oxomethyl)-4,5-dihydroisoxazole

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Technology Process of 5-(2-methoxy-2-oxoethyl)-3-(1-(3-(trifluoromethyl)phenyl)-1H-indol-3-yl)-5-(1-methoxy-1-oxomethyl)-4,5-dihydroisoxazole

There total 5 articles about 5-(2-methoxy-2-oxoethyl)-3-(1-(3-(trifluoromethyl)phenyl)-1H-indol-3-yl)-5-(1-methoxy-1-oxomethyl)-4,5-dihydroisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1283629-00-4
1-(3-(trifluoromethyl)phenyl)-1H-indole-3-carbaldehyde oxime

: 617-52-7
Dimethyl itakonate

: 1283629-12-8
5-(2-methoxy-2-oxoethyl)-3-(1-(3-(trifluoromethyl)phenyl)-1H-indol-3-yl)-5-(1-methoxy-1-oxomethyl)-4,5-dihydroisoxazole

Guidance literature:: With sodium hypochlorite; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmcl.2010.12.127

Reference yield:

: 120-72-9
indole

: 1283629-12-8
5-(2-methoxy-2-oxoethyl)-3-(1-(3-(trifluoromethyl)phenyl)-1H-indol-3-yl)-5-(1-methoxy-1-oxomethyl)-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; caesium carbonate / N,N-dimethyl-formamide / 3 h / 165 °C

2.1: trichlorophosphate / 0.25 h / 0 °C / Inert atmosphere

2.2: 2 h / 164 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride / pyridine; ethanol / 16 h / 20 °C / Inert atmosphere

4.1: sodium hypochlorite / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With sodium hypochlorite; copper(l) iodide; hydroxylamine hydrochloride; caesium carbonate; trichlorophosphate; In tetrahydrofuran; pyridine; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.12.127

Reference yield:

: 1-(3-(trifluoromethyl)phenyl)-1H-indole

: 1283629-12-8
5-(2-methoxy-2-oxoethyl)-3-(1-(3-(trifluoromethyl)phenyl)-1H-indol-3-yl)-5-(1-methoxy-1-oxomethyl)-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 0.25 h / 0 °C / Inert atmosphere

1.2: 2 h / 164 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride / pyridine; ethanol / 16 h / 20 °C / Inert atmosphere

3.1: sodium hypochlorite / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With sodium hypochlorite; hydroxylamine hydrochloride; trichlorophosphate; In tetrahydrofuran; pyridine; ethanol;
DOI:10.1016/j.bmcl.2010.12.127