3-{9-[(2R,3S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-tetrahydro-furan-2-yl]-9H-purin-6-yl}-1,1-dimethyl-urea

Base Information

• Chemical Name: 3-{9-[(2R,3S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-tetrahydro-furan-2-yl]-9H-purin-6-yl}-1,1-dimethyl-urea
• CAS No.: 124492-55-3
• Molecular Formula: C₄₀H₄₈N₆O₇Si
• Molecular Weight: 752.943
• Mol file: 124492-55-3.mol

Synonyms:3-{9-[(2R,3S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-tetrahydro-furan-2-yl]-9H-purin-6-yl}-1,1-dimethyl-urea

Chemical Property of 3-{9-[(2R,3S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-tetrahydro-furan-2-yl]-9H-purin-6-yl}-1,1-dimethyl-urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{9-[(2R,3S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-tetrahydro-furan-2-yl]-9H-purin-6-yl}-1,1-dimethyl-urea

There total 4 articles about 3-{9-[(2R,3S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-tetrahydro-furan-2-yl]-9H-purin-6-yl}-1,1-dimethyl-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

N6-(N,N'-Dimethylaminomethylene)-2'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)adenosine (124492-53-1) → N'-{9-[(2R,3S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-tetrahydro-furan-2-yl]-9H-purin-6-yl}-N,N-dimethyl-formamidine (124492-54-2) + 3-{9-[(2R,3S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-tetrahydro-furan-2-yl]-9H-purin-6-yl}-1,1-dimethyl-urea (124492-55-3)

Guidance literature:

With pyridine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dimethyl sulfoxide; benzene; at 13 ℃; for 4h;

DOI:10.1055/s-1989-27258

Reference yield:

N6-(N,N'-Dimethylaminomethylene)adenosine (17331-15-6) → 3-{9-[(2R,3S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-tetrahydro-furan-2-yl]-9H-purin-6-yl}-1,1-dimethyl-urea (124492-55-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / dimethylformamide; pyridine / 10 h / Ambient temperature

2: 80 percent / AgNO₃, pyridine / tetrahydrofuran / 2 h / Ambient temperature

3: 22 percent / pyridine, trifluoroacetic acid, dicyclohexylcarbodiimide / dimethylsulfoxide; benzene / 4 h / 13 °C

With pyridine; silver nitrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; pyridine; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene;

DOI:10.1055/s-1989-27258

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 3-{9-[(2R,3S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-tetrahydro-furan-2-yl]-9H-purin-6-yl}-1,1-dimethyl-urea (124492-55-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / dimethylformamide; pyridine / 10 h / Ambient temperature

2: 80 percent / AgNO₃, pyridine / tetrahydrofuran / 2 h / Ambient temperature

3: 22 percent / pyridine, trifluoroacetic acid, dicyclohexylcarbodiimide / dimethylsulfoxide; benzene / 4 h / 13 °C

With pyridine; silver nitrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; pyridine; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene;

DOI:10.1055/s-1989-27258

upstream raw materials:

N⁶-(N,N'-Dimethylaminomethylene)-2'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)adenosine

N⁶-(N,N'-Dimethylaminomethylene)adenosine

4,4'-dimethoxytrityl chloride

5'-O-(4,4'-dimethoxytrityl)-N⁶-dimethylaminomethyleneadenosine