2-(2-(5-fluorouracil-1-yl)acetamido)ethyl 1-(3,4-difluorophenyl)-3-methyl-1H-pyrazole-5-carboxylate

Base Information

Chemical Name:2-(2-(5-fluorouracil-1-yl)acetamido)ethyl 1-(3,4-difluorophenyl)-3-methyl-1H-pyrazole-5-carboxylate
CAS No.:1448684-60-3
Molecular Formula:C₁₉H₁₆F₃N₅O₅
Molecular Weight:451.362
Hs Code.:

Synonyms:2-(2-(5-fluorouracil-1-yl)acetamido)ethyl 1-(3,4-difluorophenyl)-3-methyl-1H-pyrazole-5-carboxylate

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Chemical Property of 2-(2-(5-fluorouracil-1-yl)acetamido)ethyl 1-(3,4-difluorophenyl)-3-methyl-1H-pyrazole-5-carboxylate

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Technology Process of 2-(2-(5-fluorouracil-1-yl)acetamido)ethyl 1-(3,4-difluorophenyl)-3-methyl-1H-pyrazole-5-carboxylate

There total 3 articles about 2-(2-(5-fluorouracil-1-yl)acetamido)ethyl 1-(3,4-difluorophenyl)-3-methyl-1H-pyrazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.5%

: 1448684-49-8
1-(3,4-difluorophenyl)-3-methyl-1H-pyrazole-5-carboxylic acid

: 84568-64-9
2-(5-fluorouracil-1-yl)-N-(2-hydroxyethyl)acetamide

: 1448684-60-3
2-(2-(5-fluorouracil-1-yl)acetamido)ethyl 1-(3,4-difluorophenyl)-3-methyl-1H-pyrazole-5-carboxylate

Guidance literature:: 1-(3,4-difluorophenyl)-3-methyl-1H-pyrazole-5-carboxylic acid; With dmap; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; for 0.5h;

2-(5-fluorouracil-1-yl)-N-(2-hydroxyethyl)acetamide; In N,N-dimethyl-formamide;
DOI:10.3184/174751914X13955977912102

Reference yield:

: 56059-30-4
5-fluorouracil-1-acetic acid

: 1448684-60-3
2-(2-(5-fluorouracil-1-yl)acetamido)ethyl 1-(3,4-difluorophenyl)-3-methyl-1H-pyrazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: peptide coupling reagent PDCP / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 20 °C

2.1: 1,1'-carbonyldiimidazole; dmap / N,N-dimethyl-formamide / 0.5 h

With dmap; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide;
DOI:10.3184/174751914X13955977912102

Reference yield:

: 1448684-42-1
C₁₃H₁₂F₂N₂O₂

: 1448684-60-3
2-(2-(5-fluorouracil-1-yl)acetamido)ethyl 1-(3,4-difluorophenyl)-3-methyl-1H-pyrazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; water / ethanol / 4 h / Reflux

2: 1,1'-carbonyldiimidazole; dmap / N,N-dimethyl-formamide / 0.5 h

With dmap; water; 1,1'-carbonyldiimidazole; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.3184/174751914X13955977912102